The double-edged role of internal limiting membrane peeling during primary rhegmatogenous retinal detachment repair

Garweg, Justus G.

doi:10.1007/s00417-021-05177-1

Cited by 2 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of our patients (87%) received ILM peeling, which makes it impossible to compare the ILM peeling group with the non-peeling group. This bias is explained by the personal experience of our surgeon (JGG), with improved visual outcomes after ILM peeling [ 7 , 9 ]. A minority (14%) of patients showed an attached foveal center, with better functional prognosis.…”

Section: Discussionmentioning

confidence: 99%

Outer retinal features in OCT predict visual recovery after primary macula-involving retinal detachment repair

et al. 2022

Self Cite

View full text Add to dashboard Cite

Purpose To find predictive markers for the visual potential in optical coherence tomography (OCT) one month after surgical repair of macula-involving rhegmatogenous retinal detachment (miRD) with and without internal limiting membrane (ILM) peeling. Methods This retrospective single-center, single-surgeon cohort study included 74 patients who underwent pars plana vitrectomy (PPV) for primary miRD between January 2013 and August 2020 with follow-up examinations for at least 6 months. Patients developing recurrent detachments, media opacities, or with an axial length over 27 mm were excluded from the analysis. LogMAR visual (VA) and LogRAD reading acuity (RA) ± standard deviation (SD), and OCT measurements 6 months after surgery were compared to OCT and VA measurements one month after surgery using multiple linear regression analysis for predictions. Results VA increased from 0.34 ± 0.25 at one month to 0.22 ± 0.21 after 6 months [p < 0.001; effect size = -0.662, 95% confidence interval (CI): -(0.99–0.33)]. The continuity of the external limiting membrane (ELM) and ellipsoid zone (EZ) increased between 1 and 6 months. Subfoveal ELM integrity after one month predicted VA [adjusted R2 of 8.0%, F(2, 71) = 4.17, p = 0.018] and RA [adjusted R2 of 29%, F(2, 27) = 6.81, p = 0.002] after 6 months. EZ integrity had a less pronounced predictive effect on VA and RA. ELM integrity after 1 month correlated with better reading acuity after 6 months (p = 0.016). Conclusion VA and morphological OCT parameters improve between 1 and 6 months after surgery for miRD. The grade of ELM is a better predictor for RA than for VA, explaining more variance.

show abstract

Section: Discussionmentioning

confidence: 99%

Outer retinal features in OCT predict visual recovery after primary macula-involving retinal detachment repair

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Posterior pole ILM peeling in the absence of posterior pole preretinal PVR has also been advocated. Two studies have found that posterior pole ILM peeling reduces the recurrence of posterior ERM formation, and one study found it reduced the risk of re-detachment [36][37][38][39]. Further study is needed to assess the benefit of posterior pole ILM peeling in cases without posterior pole PVR.…”

Section: Surgical Managementmentioning

confidence: 99%

Translational and clinical advancements in management of proliferative vitreoretinopathy

Shahlaee

Woeller

Philp

et al. 2022

Current Opinion in Ophthalmology

View full text Add to dashboard Cite

Purpose of reviewDespite advancement in the surgical instrumentation and techniques, proliferative vitreoretinopathy (PVR) remains the most common cause for failure of rhegmatogenous retinal detachment (RRD) repair. This review discusses ongoing translational and clinical advancements in PVR. Recent findingsPVR represents an exaggerated and protracted scarring process that can occur after RRD. The primary cell types involved are retinal pigment epithelium, glial, and inflammatory cells. They interact with growth factors and cytokines derived from the breakdown of the blood--retinal barrier that trigger a cascade of cellular processes, such as epithelial--mesenchymal transition, cell migration, chemotaxis, proliferation, elaboration of basement membrane and collagen and cellular contraction, leading to overt retinal pathology. Although there are currently no medical therapies proven to be effective against PVR in humans, increased understanding of the risks factors and pathophysiology have helped guide investigations for molecular targets of PVR. The leading therapeutic candidates are drugs that mitigate growth factors, inflammation, and proliferation are the leading therapeutic candidates.

show abstract

The double-edged role of internal limiting membrane peeling during primary rhegmatogenous retinal detachment repair

Cited by 2 publications

References 10 publications

Outer retinal features in OCT predict visual recovery after primary macula-involving retinal detachment repair

Outer retinal features in OCT predict visual recovery after primary macula-involving retinal detachment repair

Translational and clinical advancements in management of proliferative vitreoretinopathy

Contact Info

Product

Resources

About