The dose-effect regularity of artificial dermis combined with growth factor in repair wound of luxation of the bone tendon

Abstract

To investigate the treatment efficacy of the artificial dermis combined with growth factor surgery in patients with luxation of bone tendon (LBT). A total of 40 patients with LBT in our prospective clinical research are randomly allocated to following four groups: Control, low dose, medium dose, and high dose. The baseline characteristics, skin graft interval time, overage rate of regenerated tissue at bone and tendon, and visual estimation of patients were measured, which were then utilized to assess the treatment efficacy of the artificial dermis combined with growth factor surgery in LBT patients. Our outcomes indicated that the artificial dermis combined with growth factor surgery showed significantly less skin graft interval time, higher overage rate of regenerated tissue at bone and tendon, less Vancouver scar scale score compared to those treated by conventional imaging technology (all P < 0.05). It concludes that the artificial dermis combined with growth factor surgery can improve the treatment efficacy, and the medium dose growth factor is a promise dose to treat the patients with LBT.