The Dose‐Dependent Effect of Curcumin Supplementation on Inflammatory Response and Gut Microbiota Profile in High‐Fat Fed C57BL/6 Mice

Bertoncini‐Silva, Caroline; Fassini, Priscila Giacomo; Carlos, Daniela; de Paula, Natália Aparecida; Ramalho, Leandra Náira Zambelli; Rodrigues Giuliani, Marina; Pereira, Ítalo Sousa; Guimarães, Jhefferson Barbosa; Suen, Vivian Marques Miguel

doi:10.1002/mnfr.202300378

Cited by 6 publications

(2 citation statements)

References 67 publications

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“…Bertoncini-Silva et al studied C57BL/6 male mice fed a HFD with different doses of curcumin (50, 250, and 500 mg/kg body weight), and they observed that, in the liver, there was a reduction in TNF-α at all three doses and an increase in IL-10 at doses of 50 and 250 mg/kg body weight [ 130 ].…”

Section: Curcumin and Curcuminoidsmentioning

confidence: 99%

Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment

Bertoncini-Silva,

Vlad,

Ricciarelli

et al. 2024

Antioxidants

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Curcumin, a natural polyphenolic component from Curcuma longa roots, is the main bioactive component of turmeric spice and has gained increasing interest due to its proposed anti-cancer, anti-obesity, anti-inflammatory, antioxidant, and lipid-lowering effects, in addition to its thermogenic capacity. While intake from dietary sources such as curry may be sufficient to affect the intestinal microbiome and thus may act indirectly, intact curcumin in the body may be too low (<1 microM) and not sufficient to affect signaling and gene expression, as observed in vitro with cultured cells (10–20 microM). Several strategies can be envisioned to increase curcumin levels in the body, such as decreasing its metabolism or increasing absorption through the formation of nanoparticles. However, since high curcumin levels could also lead to undesired regulatory effects on cellular signaling and gene expression, such studies may need to be carefully monitored. Here, we review the bioavailability of curcumin and to what extent increasing curcumin levels using nanoformulations may increase the bioavailability and bioactivity of curcumin and its metabolites. This enhancement could potentially amplify the disease-preventing effects of curcumin, often by leveraging its robust antioxidant properties.

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Section: Curcumin and Curcuminoidsmentioning

confidence: 99%

Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment

Bertoncini-Silva,

Vlad,

Ricciarelli

et al. 2024

Antioxidants

Self Cite

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“…Astragalus polysaccharides , the main effective component of Astragalus mongholicus Bunge, significantly regulated most microorganisms, such as Bifidobacterium pseudolongum , Lactobacillus johnsonii and Lactobacillus , the changes in abundance of these microorganisms were related to the increase of metabolites, which could control tumor growth ( Ding et al, 2021 ). The main active ingredients of Curcuma aromatica Salisb., curcumin showed the dose-dependent suppressive effect on inflammatory response and gut microbiota profile in high-fat fed C57BL/6 mice ( Bertoncini-Silva et al, 2023 ). The intricate mechanisms supporting this therapeutic effect, however, still need to be clarified.…”

Section: Introductionmentioning

confidence: 99%

Astragalus mongholicus Bunge and Curcuma aromatica Salisb. modulate gut microbiome and bile acid metabolism to inhibit colon cancer progression

Wang,

Zhu,

Hua

et al. 2024

Front. Microbiol.

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IntroductionAlterations in the gut microbiome and bile acid metabolism are known to play a role in the development and progression of colon cancer. Medicinal plants like Astragalus mongholicus Bunge and Curcuma aromatica Salisb. (AC) have shown preferable therapeutic effect on cancer therapy, especially digestive tract tumors like colon cancer. However, the precise mechanisms of AC inhibiting colon cancer, particularly in relation to the gut microbiome and bile acid dynamics, are not fully understood.MethodsOur research aimed to investigate the anti-tumor properties of AC in mice with CT26 colon cancer and further investigate its underlying mechanism via intestinal microbiota. The size and pathological changes of solid tumors in colon cancer are used to evaluate the inhibitory effect of AC on colon cancer. Metagenomics and 16s rRNA gene sequencing were employed to clarify the dysbiosis in the gut microbiome of colon cancer and its impact on colon cancer. The levels of bile acids (BAs) in the feces of mice from each group were measured using UPLC-Qtrap-MS/MS.ResultsAC effectively suppressed the growth of colon cancer and reduced histological damage. Notably, AC treatment led to changes in the gut microbiome composition, with a decrease in pathogenic species like Citrobacter and Candidatus_Arthromitus, and an increase in beneficial microbial populations including Adlercreutzia, Lachnospiraceae_UCG-001, and Parvibacter. Additionally, AC altered bile acid profiles, resulting in a significant decrease in pro-carcinogenic bile acids such as deoxycholic acid (DCA) and lithocholic acid (LCA), while increasing the concentration of the cancer-inhibitory bile acid, ursodeoxycholic acid (UDCA). Tracking and analyzing the data, AC may mainly upregulate FabG and baiA genes by increasing the relative abundance of Adlercreutzia and Parvibacter bacteria, which promoting the metabolism of pro-carcinogenic LCA.DiscussionThese findings provide strong evidence supporting the role of AC in regulating gut microbiome-mediated bile acid metabolism, which is crucial in impeding the progression of colon cancer.

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Raspberry Ketone Prevents LPS‐Induced Depression‐Like Behaviors in Mice by Inhibiting TLR‐4/NF‐κB Signaling Pathway via the Gut‐Brain Axis

Liu,

Dai,

Wang

et al. 2024

Molecular Nutrition Food Res

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ScopeDepression, a prevalent mental disorder, has significantly impacted the lives of 350 million people, yet it holds promise for amelioration through food‐derived phenolics. Raspberries, renowned globally for their delectable flavor, harbor a phenolic compound known as raspberry ketone (RK). However, the impact of RK on depressive symptoms remains ambiguous. This study aims to investigate the impact of RK on lipopolysaccharide (LPS)‐induced depressed mice and elucidates its potential mechanisms, focusing on the gut‐brain axis.Methods and resultsThrough behavioral tests, RK exerts a notable preventive effect on LPS‐induced depression‐like behaviors in mice. RK proves capable of attenuating gut inflammation, repairing gut barrier impairment, modulating the composition of the gut microbiome (Muribaculaceae, Streptococcus, Lachnospiraceae, and Akkermansia), and promoting the production of short‐chain fatty acids. Furthermore, RK alleviates neuroinflammation by suppressing the TLR‐4/NF‐κB pathway and bolsters synaptic function by elevating levels of neurotrophic factors and synapse‐associated proteins.ConclusionThe current study provides compelling evidence that RK effectively inhibits the TLR‐4/NF‐κB pathway via the gut‐brain axis, leading to the improvement of LPS‐induced depression‐like behaviors in mice. This study addresses the research gap in understanding the antidepressant effects of RK and illuminates the potential of utilizing RK as a functional food for preventing depression.

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The Dose‐Dependent Effect of Curcumin Supplementation on Inflammatory Response and Gut Microbiota Profile in High‐Fat Fed C57BL/6 Mice

Cited by 6 publications

References 67 publications

Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment

Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment

Astragalus mongholicus Bunge and Curcuma aromatica Salisb. modulate gut microbiome and bile acid metabolism to inhibit colon cancer progression

Raspberry Ketone Prevents LPS‐Induced Depression‐Like Behaviors in Mice by Inhibiting TLR‐4/NF‐κB Signaling Pathway via the Gut‐Brain Axis

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