The dorsal subiculum is required for contextual fear conditioning consolidation in rats

Melo, Márcio Braga de; Favaro, Vanessa Manchim; Oliveira, Maria Gabriela Menezes

doi:10.1016/j.bbr.2020.112661

Cited by 10 publications

(24 citation statements)

References 32 publications

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“…The results showed that pre-or posttraining infusions of AP5 or muscimol into the DSub disrupted neither the latency to cross from the light to dark chamber, nor the freezing time in the dark chamber, that is, the manipulations did not affect ST IA acquisition and consolidation. Therefore, our initial hypothesis that the DSub involvement shown in respect of fear conditioning (Melo et al, 2020) would also be found in the ST IA was not supported; This led us to make the following observations. First, although both CFC and ST IA are aversive learning behavioral paradigms that involve associations between stimuli and fear conditioning learning, there is a critical difference between This document is copyrighted by the American Psychological Association or one of its allied publishers.…”

Section: Discussionmentioning

confidence: 90%

“…The control group animals received the same volume of 0.9% saline solution. The coordinates, infusion volumes, and drug concentrations were the same as in our previous work manipulating the DSub (Melo et al, 2020), providing a "positive control" for the present study.…”

Section: Stereotaxic Surgery Infusion Procedure and Histologymentioning

confidence: 99%

“…in CFC consolidation (Melo et al, 2020). CFC is an aversive learning paradigm that involves the association between an unconditioned stimulus (usually a footshock), and a conditioned stimulus (usually a determined environment) in classical Pavlovian conditioning (Pavlov, 1927;Phillips & LeDoux, 1992).…”

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confidence: 99%

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The dorsal subiculum is not necessary for step-through inhibitory avoidance acquisition and consolidation in rats.

Melo¹,

Oliveira²,

Favaro³

2021

Behavioral Neuroscience

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The dorsal subiculum (DSub) has reciprocal connections with the dorsal hippocampus, and these regions play a role in spatial representation in contextual fear conditioning (CFC). Recently, we used AP5 and muscimol infusions to show that the DSub is required for CFC consolidation. The CFC component can be present in other learning tasks, such as step-through inhibitory avoidance (ST IA), which requires the dorsal hippocampus for acquisition and consolidation. This suggests that the DSub may be also involved in ST IA if the CFC component of the protocol is strong enough. Therefore, this study tested whether the DSub participates in ST IA acquisition and consolidation in male Wistar rats. Our data showed that pre-or posttraining infusions of AP5 or muscimol into the DSub did not affect ST IA acquisition and consolidation. We discuss the present results in relation to our previous findings, which showed the involvement of the DSub in CFC consolidation, and highlight some reasons that may explain the divergent results between the tasks. First, we note the possibility to escape from the unconditioned stimulus that occurs in ST IA, but not in CFC. We also suggest that the instrumental component of ST IA seems to be more prominent than the CFC one. Finally, we consider the possible influence of aspects of anxiety present in the ST IA, but not in CFC. These possible interpretations provide a broad framework in respect of the present results and raise new questions that demand further studies exploring the DSub function in inhibitory avoidance.

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Section: Discussionmentioning

confidence: 90%

Section: Stereotaxic Surgery Infusion Procedure and Histologymentioning

confidence: 99%

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The dorsal subiculum is not necessary for step-through inhibitory avoidance acquisition and consolidation in rats.

Melo¹,

Oliveira²,

Favaro³

2021

Behavioral Neuroscience

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“…Also, place cells in the subiculum are more attuned to movement-related factors, such as direction and motion, during navigation compared with CA1 place cells [13][14][15][16]. A few studies have also suggested that the subiculum is essential in remembering places and environmental contexts [17][18][19][20][21]. However, the exact roles of subicular neurons, especially in a goal-directed memory task, still remain largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Subicular neurons represent multiple variables of a hippocampal-dependent task by using theta rhythm

2022

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The subiculum is positioned at a critical juncture at the interface of the hippocampus with the rest of the brain. However, the exact roles of the subiculum in most hippocampal-dependent memory tasks remain largely unknown. One obstacle to make comparisons of neural firing patterns between the subiculum and hippocampus is the broad firing fields of the subicular cells. Here, we used spiking phases in relation to theta rhythm to parse the broad firing field of a subicular neuron into multiple subfields to find the unique functional contribution of the subiculum while male rats performed a hippocampal-dependent visual scene memory task. Some of the broad firing fields of the subicular neurons were successfully divided into multiple subfields similar to those in the CA1 by using the theta phase precession cycle. The new paradigm significantly improved the detection of task-relevant information in subicular cells without affecting the information content represented by CA1 cells. Notably, we found that multiple fields of a single subicular neuron, unlike those in the CA1, carried heterogeneous task-related information such as visual context and choice response. Our findings suggest that the subicular cells integrate multiple task-related factors by using theta rhythm to associate environmental context with action.

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“…Also, place cells in the subiculum are more attuned to movement-related factors, such as direction and motion, during navigation compared with CA1 place cells (Lever et al, 2009;Olson et al, 2017;Kitanishi et al, 2021;Ledergerber et al, 2021). A few studies have also suggested that the subiculum is essential in remembering places and environmental contexts (Morris et al, 1990;Potvin et al, 2007Potvin et al, , 2009Potvin et al, 2010;Melo et al, 2020). However, the exact roles of subicular neurons, especially in a goal-directed memory task, still remain largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Orthogonal representation of task-related information in theta phase-based multiple place fields of single units in the subiculum

Lee

Seol

Lee

2021

Preprint

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The subiculum is positioned at a critical juncture at the interface of the hippocampus with the rest of the brain. However, the exact roles of the subiculum in most hippocampal-dependent memory tasks remain largely unknown. One obstacle to make analytical comparisons of neural firing patterns between the subiculum and hippocampal CA1 is the broad firing fields of the subicular cells. Here, we used spiking phases in relation to theta rhythm to parse the broad firing field of a subicular neuron into multiple subfields to find the unique functional contribution of the subiculum while male rats performed a hippocampal-dependent visual scene memory task. Some of the broad firing fields of the subicular neurons were successfully divided into multiple subfields by using the theta-phase precession cycle. The resulting phase-based fields in the subiculum were more similar to those in CA1 in terms of the field size and phase-precession strength. The new method significantly improved the detection of task-relevant information in subicular cells without affecting the information content represented by CA1 cells. Notably, multiple fields of a single subicular neuron, unlike those in the CA1, could carry heterogeneous task-related information such as visual context and choice response. Our findings suggest that the subicular cells integrate multiple task-related factors by using theta rhythm to associate environmental context with action.

show abstract

The dorsal subiculum is required for contextual fear conditioning consolidation in rats

Cited by 10 publications

References 32 publications

The dorsal subiculum is not necessary for step-through inhibitory avoidance acquisition and consolidation in rats.

The dorsal subiculum is not necessary for step-through inhibitory avoidance acquisition and consolidation in rats.

Subicular neurons represent multiple variables of a hippocampal-dependent task by using theta rhythm

Orthogonal representation of task-related information in theta phase-based multiple place fields of single units in the subiculum

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