The dopaminergic innervation of the ventral striatum in the rat: A light‐ and electron‐microscopical study with antibodies against dopamine

Voorn, Pieter; Jorritsma‐Byham, Barbara; Dijk, C. van; Buijs, R.M.

doi:10.1002/cne.902510106

Cited by 294 publications

(144 citation statements)

References 60 publications

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“…The ventral shell receives more inputs from accessory basal and magnocellular basal nuclei (Wright et al, 1996). In efferent projections, the dorsal shell sends more outputs to the medioventral tegmental area (Voorn et al, 1986;Berendse et al, 1992), whereas the ventral shell sends more to the lateroventral tegmental area (Berendse et al, 1992).…”

Section: Neuroanatomical Compartmentalization In Medial Shellmentioning

confidence: 99%

Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?

Peciña¹,

Berridge²

2005

J. Neurosci.

592

493

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-Opioid systems in the medial shell of the nucleus accumbens contribute to hedonic impact ("liking") for sweetness, food, and drug rewards. But does the entire medial shell generate reward hedonic impact? Or is there a specific localized site for opioid enhancement of hedonic "liking" in the medial shell? And how does enhanced taste hedonic impact relate to opioid-stimulated increases in food intake? Here, we used a functional mapping procedure based on microinjection Fos plumes to localize opioid substrates in the medial shell of the nucleus accumbens that cause enhanced "liking" reactions to sweet pleasure and that stimulate food intake. We mapped changes in affective orofacial reactions of "liking"/"disliking" elicited by sucrose or quinine tastes after D-Ala 2 -N-Me-Phe 4 -Glycol 5-enkephalin (DAMGO) microinjections in rats and compared hedonic increases to food intake stimulated at the same sites. Our maps indicate that opioid-induced increases in sucrose hedonic impact are generated by a localized cubic millimeter site in a rostrodorsal region of the medial shell. In contrast, all regions of the medial shell generated DAMGO-induced robust increases in eating behavior and food intake. Thus, our results identify a locus for opioid amplification of hedonic impact and reveal a distinction between opioid mechanisms of food intake and hedonic impact. Opioid circuits for stimulating food intake are widely distributed, whereas hedonic "liking" circuits are more tightly localized in the rostromedial shell of the nucleus accumbens.

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Section: Neuroanatomical Compartmentalization In Medial Shellmentioning

confidence: 99%

Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?

Peciña¹,

Berridge²

2005

J. Neurosci.

592

493

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“…Recently, it has become evident that the nucleus accumbens is a heterogeneous structure. At least two different parts can be discerned: the shell and the core (Voorn et al 1986;Groenewegen et al 1987;Heimer et al 1991;Zahm and Brog 1992;Brog et al ted from the shell was significantly attenuated by prior 1993; Meredith et a l 1993;Jongen-Relo et al 1994). administration of either the dopamine D?…”

Section: Introductionmentioning

confidence: 99%

“…administration of either the dopamine D? receptor The s^ie^ an^ the core appear to be innervated by antagonist /-sulpiride (25 ng/0.5 ul) or the dopamine different sets of dopaminergic neurons (Voorn et al 1986;Zahm 1991Zahm , 1992. The shell contains a richer dopamine plexus than the core (Voorn et al 1986), and the concentration of dopamine in the shell is higher than that in the core (Deutch and Cameron 1992).…”

Section: Introductionmentioning

confidence: 99%

Contralateral turning elicited by unilateral stimulation of dopamine D2 and D1 receptors in the nucleus accumbens of rats is due to stimulation of these receptors in the shell, but not the core, of this nucleus

et al. 1996

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The goal of this study was to determine whether dopamine D 2 and/or Dj receptors in the shell and the core of the nucleus accumbens of rats have a differential role in turning behaviour. Unilateral injec tion of a mixture of the dopamine D2 receptor agonist quinpirole (10 \ig) and the dopamine Di receptor ago nist 1-phenyl-2,3,4,5-tetrahydro-l//-3-benzazepine-7, 8-diol (SKF 38393, 5 jig) into the shell of the nucleus accumbens produced contralateral turning, when doses which per se were ineffective were injected. This effect was far greater than that found after similar injections into the core of the nucleus accumbens. The effect elici-

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“…At least two different parts can be discerned: the shell and the core (Voorn et al, 1986;Groenewegen et al, 1987;Heimer et al, 1991;Zahm and Brog, 1992;Brog et ah, 1993;Meredith et al, 1993;Jongen-Relo et al, 1994). The shell and the core appear to be innervated by different sets of dopaminergic neurons (Voorn et al, 1986;Zahm, 1991Zahm, , 1992.…”

Section: Introductionmentioning

confidence: 99%

“…The shell and the core appear to be innervated by different sets of dopaminergic neurons (Voorn et al, 1986;Zahm, 1991Zahm, , 1992. The shell contains a richer dopamine plexus than the core (Voorn et al, 1986), and the concentration of dopamine in the shell is higher than that in the core (Deutch and Cameron, 1992). The shell is less vulnerable to the neurotoxic 42 A.R.…”

Section: Introductionmentioning

confidence: 99%

Role of dopamine D1 and D2 receptors in the nucleus accumbens in jaw movements of rats: a critical role of the shell

Cools

Miwa

Koshikawa

1995

European Journal of Pharmacology

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Given the differences in the dopamine neurotransmission between the shell and the core of the nucleus accumbens, as well as the differential involvement of these two domains in oral behaviour of rats, it was decided to determine whether or not dopamine Dj and/or dopamine D 2 receptors differentially direct oral behaviour in these two domains in rats. Intra-accumbens injections of the dopamine D, receptor agonist ( + )-6-chloro-7,S-dihydroxy-3-alIyl-1 -phenyl-2,3,4,5-letrahydro-l/7-3-benzazepine (SKF 82958: 5 jiig/0.2 /¿I), the dopamine D2 receptor agonist quinpirole (10 ju,g/0.2 ¡j. 1) and their combination were used to assess the role of these accumbens domains in jaw movements of rats. The present study shows that the combined administration of SKF 82958 and quinpirole into the shell, but not the core, of the nucleus accumbens produced a highly significant increase in jaw movements, when doses which per se were nearly ineffective, were injected. This effect was fully inhibited by prior administra tion of either the dopamine D [ receptor antagonist 7M + )-7-chloro-8-hydroxy-3-methyl-l-phenyl-2,3,4,5-tetrahydro-l //-3-benzazepine (SCH 23390: 0.5 ¿¿g/0.2 ¡M g) or the dopamine D 2 receptor antagonist (-)-sulpiride (25 ng/0.5 /xl) into the same region. It is concluded that dopamine D, and D 2 receptors in the shell, but not the core, of the nucleus accumbens are involved in jaw movements of the rat, providing the first piece of evidence that dopamine Dj and D 2 receptors in the shell of the nucleus accumbens mediate a particular behaviour.

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The dopaminergic innervation of the ventral striatum in the rat: A light‐ and electron‐microscopical study with antibodies against dopamine

Cited by 294 publications

References 60 publications

Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?

Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?

Contralateral turning elicited by unilateral stimulation of dopamine D2 and D1 receptors in the nucleus accumbens of rats is due to stimulation of these receptors in the shell, but not the core, of this nucleus

Role of dopamine D1 and D2 receptors in the nucleus accumbens in jaw movements of rats: a critical role of the shell

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