The Dominant Antigenic Group of Influenza C Infections Changed from C/Sao Paulo/378/82-Lineage to C/Kanagawa/1/76-Lineage in Yamagata, Japan, in 2014

Tanaka, Shizuka; Aoki, Yoko; Matoba, Yohei; Yahagi, Kazue; Mizuta, Katsumi; Itagaki, Tsutomu; Katsushima, Fumio; Katsushima, Yuriko; Matsuzaki, Yoko

doi:10.7883/yoken.jjid.2014.520

Cited by 10 publications

(17 citation statements)

References 11 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rates of nucleotide substitution of individual segments ranged from 3.76 ϫ 10 Ϫ4 to 5.20 ϫ 10 Ϫ4 (strict clock) and from 3.87 ϫ 10 Ϫ4 to 5.23 ϫ 10 Ϫ4 (relaxed clock) substitutions/site/year, with the lowest and highest rates found for the P3 and HE genes, respectively. (17,19,20,21,22,24,32), Kimura et al (18), and Tanaka et al (25). The colored open squares indicate the representative reassortant viruses that emerged during influenza C virus epidemics.…”

Section: Virusesmentioning

confidence: 99%

“…Twenty-five strains isolated before 1988 were used that had been used in our previous studies (17,19,26,31,33) and kept in our laboratory. The remaining strains were isolated by our surveillance in Japan as described previously (17)(18)(19)(20)(21)(22)(23)(24)(25)32). The viruses were all propagated in the amniotic cavity of 8-or 9-day-old embryonated hen eggs, and they were stored at Ϫ80°C until use for sequencing.…”

Section: Virusesmentioning

confidence: 99%

“…The viruses were all propagated in the amniotic cavity of 8-or 9-day-old embryonated hen eggs, and they were stored at Ϫ80°C until use for sequencing. The HE, NP, M, and/or NS gene sequences of some viruses had been determined in our previous studies (17)(18)(19)(20)(21)(22)(23)(24)(25)(31)(32)(33)(34)(35)(36)(37). Nucleotide sequences determined in our laboratory and registered in DDBJ/GenBank were used for C/Ann Arbor/1/50 (38,39).…”

Section: Virusesmentioning

confidence: 99%

“…This long-term surveillance revealed that there are several antigenic groups among influenza C viruses, and this antigenic difference is cross-reactive but distinguishable by analysis with human antibodies and anti-HE monoclonal antibodies (17)(18)(19)(20)(21)(22)(24)(25)(26). Influenza C viruses belonging to the different antigenic groups cocirculated in the community, and replacement of the dominant antigenic group occurred every few years as a result of selection by herd immunity (24).…”

mentioning

confidence: 97%

“…Since 1988, we have monitored influenza C virus infections in Japan using a cell culture method, and we succeeded in repeatedly detecting outbreaks by 2014 (17)(18)(19)(20)(21)(22)(23)(24)(25). This long-term surveillance revealed that there are several antigenic groups among influenza C viruses, and this antigenic difference is cross-reactive but distinguishable by analysis with human antibodies and anti-HE monoclonal antibodies (17)(18)(19)(20)(21)(22)(24)(25)(26).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Genetic Lineage and Reassortment of Influenza C Viruses Circulating between 1947 and 2014

Matsuzaki

Sugawara

Furuse

et al. 2016

J Virol

Self Cite

View full text Add to dashboard Cite

Since influenza C virus was first isolated in 1947, the virus has been only occasionally isolated by cell culture; there are only four strains for which complete genome sequences are registered. Here, we analyzed a total of 106 complete genomes, ranging from the first isolate from 1947 to recent isolates from 2014, to determine the genetic lineages of influenza C virus, the reassortment events, and the rates of nucleotide substitution. The results showed that there are six lineages, named C/Taylor, C/Mississippi, C/Aichi, C/Yamagata, C/Kanagawa, and C/Sao Paulo. They contain both antigenic and genetic lineages of the hemagglutininesterase (HE) gene, and the internal genes PB2, PB1, P3, NP, M, and NS are divided into two major lineages, a C/Mississippi/80-related lineage and a C/Yamagata/81-related lineage. Reassortment events were found over the entire period of 68 years. Several outbreaks of influenza C virus between 1990 and 2014 in Japan consisted of reassortant viruses, suggesting that the genomic constellation is related to influenza C virus epidemics. The nucleotide sequences were highly homologous to each other. The minimum percent identity between viruses ranged from 91.1% for the HE gene to 96.1% for the M gene, and the rate of nucleotide substitution for the HE gene was the highest, at 5.20 ؋ 10 ؊4 substitutions/site/year. These results indicate that reassortment is an important factor that increases the genetic diversity of influenza C virus, resulting in its ability to prevail in humans. However, the antigenicity of the HE glycoprotein is highly stable, and antigenic drift has not occurred for at least 30 years. Here, we analyzed a total of 106 complete genomes spanning 68 years for the first time, and we found that influenza C viruses are circulating worldwide while undergoing reassortment as well as selection by herd immunity, resulting in an increased ability to prevail in humans. The results presented in this study contribute to the understanding of the evolution, including reassortment events, underlying influenza C virus epidemics. IMPORTANCE Influenza C virus is a pathogen that causes acute respiratory illness in children and

show abstract

Section: Virusesmentioning

confidence: 99%

Section: Virusesmentioning

confidence: 99%

Section: Virusesmentioning

confidence: 99%

mentioning

confidence: 97%

mentioning

confidence: 99%

See 3 more Smart Citations

Genetic Lineage and Reassortment of Influenza C Viruses Circulating between 1947 and 2014

Matsuzaki

Sugawara

Furuse

et al. 2016

J Virol

Self Cite

View full text Add to dashboard Cite

show abstract

Genetic and antigenic characteristics of a human influenza C virus clinical isolate

Liu

Sheng

Lin

et al. 2019

Journal of Medical Virology

View full text Add to dashboard Cite

Unlike influenza A and B viruses that infect humans and cause severe diseases in seasonal epidemics, influenza C virus (ICV) is a ubiquitous childhood pathogen typically causing mild respiratory symptoms. ICV infections are rarely diagnosed and less research has been performed on it despite the virus being capable of causing severe disease in infants. Here we report on the isolation of a human ICV from a child with acute respiratory disease, provisionally designated C/Victoria/2/2012 (C/Vic). The full‐length genome sequence and phylogenetic analysis revealed that the hemagglutinin‐esterase‐fusion (HEF) gene of C/Vic was derived from C/Sao Paulo lineage, while its PB2 and P3 genes evolved separately from all characterized historical ICV isolates. Furthermore, antigenic analysis using the hemagglutination inhibition (HI) assay found that 1947 C/Taylor virus (C/Taylor lineage) was antigenically more divergent from1966 C/Johannesburg (C/Aichi lineage) than from 2012 C/Vic. Structure modeling of the HEF protein identified two mutations in the 170‐loop of the HEF protein around the receptor‐binding pocket as a possible antigenic determinant responsible for the discrepant HI results. Taken together, results of our studies reveal novel insights into the genetic and antigenic evolution of ICV and provide a framework for further investigation of its molecular determinants of antigenic property and replication.

show abstract

Antigenic changes among the predominantly circulating C/Sao Paulo lineage strains of influenza C virus in Yamagata, Japan, between 2015 and 2018

Matsuzaki

Shimotai

Kadowaki

et al. 2020

Infection, Genetics and Evolution

View full text Add to dashboard Cite

The Dominant Antigenic Group of Influenza C Infections Changed from C/Sao Paulo/378/82-Lineage to C/Kanagawa/1/76-Lineage in Yamagata, Japan, in 2014

Cited by 10 publications

References 11 publications

Genetic Lineage and Reassortment of Influenza C Viruses Circulating between 1947 and 2014

Genetic Lineage and Reassortment of Influenza C Viruses Circulating between 1947 and 2014

Genetic and antigenic characteristics of a human influenza C virus clinical isolate

Antigenic changes among the predominantly circulating C/Sao Paulo lineage strains of influenza C virus in Yamagata, Japan, between 2015 and 2018

Contact Info

Product

Resources

About