The dog as an animal model for DISH?

Abstract

Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic disorder of the axial and peripheral skeleton in humans and has incidentally been described in dogs. The aims of this retrospective radiographic cohort study were to determine the prevalence of DISH in an outpatient population of skeletally mature dogs and to investigate if dogs can be used as an animal model for DISH. The overall prevalence of canine DISH was 3.8% (78/2041). The prevalence of DISH increased with age and was more frequent in male dogs, similar to findings in human studies. In the Boxer breed the prevalence of DISH was 40.6% (28/69). Dog breeds represent closed gene pools with a high degree of familiar relationship and the high prevalence in the Boxer may be indicative of a genetic origin of DISH. It is concluded that the Boxer breed may serve as an animal model for DISH in humans.

Radiographic and MRI characteristics of lumbar disseminated idiopathic spinal hyperostosis and spondylosis deformans in dogs

“…This is illustrated in the radiographic investigation by Kranenburg et al. () in which up to three reviews by different investigators were necessary until a consensus about the diagnosis of DISH was established in some of their cases.…”

“…Canine DISH has been proposed as a spontaneous model for the disorder in humans (Larsen & Selby , Eichelberg & Wurster , Kranenburg et al. ). The aetiology of canine DISH is unknown, but a hereditary basis has been suggested for boxers (Langeland & Lingaas ).…”

Dorsal vertebral column abnormalities in dogs with disseminated idiopathic skeletal hyperostosis (DISH)

“…Although DISH is relative commonly encountered in humans (Holton and others 2011), only a few reports have discussed its presence in dogs (Kranenburg and others 2011, Ortega and others 2012). A recent radiographic study has estimated the prevalence of DISH to be 3.8 per cent in clinically normal dogs with a significantly higher prevalence in older animals, males and the Boxer breed (Kranenburg and others 2010). Although DISH can affect multiple anatomical structures, it affects most typically the ventral longitudinal ligament, resulting in the formation of contiguous bone ventral to the vertebral column with complete bony fusion of consecutive vertebral segments (Kranenburg and others 2011).…”

Spinal hyperostosis in humans and companion animals

“…These types were described to be comparable with those seen in human ankylosing hyperostosis (former name for DISH) (Wright 1982a(Wright , 1982b. Recent reports of the prevalence of spondylosis and DISH in a group of pedigree dogs and in a group of cats used a comparable system as is depicted in Figure 4 (Kranenburg et al 2010;Kranenburg et al 2011;Kranenburg et al 2012). Other studies of canine vertebral hyperostosis did not specifically distinguish between these two different disorders, i.e., spondylosis and DISH (Morgan et al 1967;Read & Smith 1968;Wright 1982b;Langeland & Lingaas 1995;Carnier et al 2004).…”

“…Recently, a retrospective radiographic study on the prevalence of both DISH and spondylosis in a large group (n ¼ 2041) of pure-bred dogs was reported (Kranenburg et al 2010;Kranenburg et al 2011). Canine DISH and spondylosis were found alone or in combination, and the prevalence of both disorders increased with age.…”