The DNA Sequences Required for Apolipoprotein B Expression in the Heart are Distinct from those Required for Expression in the Intestine

Nielsen, Lars Bo; Sullivan, Meghan; Vanni-Reyes, Teresa; Goldberg, Ira J.; Young, Stephen G.

doi:10.1006/jmcc.1998.0918

Cited by 17 publications

(16 citation statements)

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“…However, it is unlikely that lipoprotein synthesis is important in all cells (e.g. as a generally expressed pathway for removal of excess triglycerides) simply because the apoB expression levels are extremely low or undetectable in tissues other than those discussed above, including skeletal muscle, adipose tissue, lung, and spleen (7,33).…”

Section: Mtp and Apob Expression In The Humanmentioning

confidence: 99%

Human Placenta Secretes Apolipoprotein B-100-containing Lipoproteins

Madsen

Lindegaard

Andersen

et al. 2004

Journal of Biological Chemistry

105

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35 S-labeled apoB-100 was recovered in d ϳ1.02-1.04 g/ml particles (i.e. similar to the density of plasma low density lipoproteins). Electron microscopy of negatively stained lipoproteins secreted from placental tissue showed spherical particles with a diameter of 47 ؎ 10 nm. These results demonstrate that human placenta expresses both apoB and MTP and consequently synthesize and secrete apoB-100-containing lipoproteins. Placental lipoprotein formation constitutes a novel pathway of lipid transfer from the mother to the developing fetus.

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Section: Mtp and Apob Expression In The Humanmentioning

confidence: 99%

Human Placenta Secretes Apolipoprotein B-100-containing Lipoproteins

Madsen

Lindegaard

Andersen

et al. 2004

Journal of Biological Chemistry

105

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“…Determination of the differentiation of Caco-2 cells by measuring sucrase activity has been described before (48). Cells were plated in Transwells, and the effect of TGF-␤ was studied at different times (5,10,11,12,14,16,18,20,22,24,30, and 36 days after plating) as described in the legend to Fig. 1.…”

Section: Effect Of Tgf-␤ Is Independent Of the State Of Differentiatimentioning

confidence: 99%

Differential, Tissue-specific, Transcriptional Regulation of Apolipoprotein B Secretion by Transforming Growth Factor β

Singh

Batuman

Akman

et al. 2002

Journal of Biological Chemistry

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“…[1][2][3][4] In addition, the apoB and MTP genes also are expressed by cardiac myocytes, which secrete apoBcontaining lipoproteins. [5][6][7] In the intestine the apoB mRNA is edited, resulting in formation of a truncated apoB, ie, apoB48. The apoB mRNA is not edited in the heart, 5 and the heart secretes lipoproteins containing the full-length apoB, ie, apoB100.…”

mentioning

confidence: 99%

“…[5][6][7] In the intestine the apoB mRNA is edited, resulting in formation of a truncated apoB, ie, apoB48. The apoB mRNA is not edited in the heart, 5 and the heart secretes lipoproteins containing the full-length apoB, ie, apoB100. 7 The physiological importance of lipoprotein secretion from the heart is unknown.…”

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confidence: 99%

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Microsomal Triglyceride Transfer Protein Gene Expression and Triglyceride Accumulation in Hypoxic Human Hearts

Nielsen

Perko

Arendrup

et al. 2002

ATVB

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Objectives-Cardiac myocytes secrete apolipoprotein (apo)B-containing lipoproteins. Their function may be the removal of triglycerides when ␤-oxidation of fatty acids is decreased, eg, during hypoxia. To test this hypothesis, we examined heart biopsies from patients undergoing coronary artery bypass graft (CABG, nϭ13) (MTP). ApoB forms the structural backbone of the triglyceride-rich lipoproteins acquiring neutral lipids during its translation and translocation into the lumen of the endoplasmatic reticulum. 1 MTP transfers the lipids onto the apoB polypeptide. 2 The apoB and MTP genes are expressed in the liver, intestine, and yolk sac. [1][2][3][4] In addition, the apoB and MTP genes also are expressed by cardiac myocytes, which secrete apoBcontaining lipoproteins. [5][6][7] In the intestine the apoB mRNA is edited, resulting in formation of a truncated apoB, ie, apoB48. The apoB mRNA is not edited in the heart, 5 and the heart secretes lipoproteins containing the full-length apoB, ie, apoB100. 7 The physiological importance of lipoprotein secretion from the heart is unknown. It has been proposed that lipoprotein formation in the heart serves as a pathway for removing triglycerides that are not used as fuel. 5,7 In the healthy heart, ␤-oxidation of fatty acids provides Ϸ70% of the energy. 8 However, during ischemia, glucose becomes the major energy substrate. 9 Studies of experimentally infarcted rat and dog hearts have shown accumulation of lipid droplets in the border zone of the infarcted area. 10

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The DNA Sequences Required for Apolipoprotein B Expression in the Heart are Distinct from those Required for Expression in the Intestine

Cited by 17 publications

References 0 publications

Human Placenta Secretes Apolipoprotein B-100-containing Lipoproteins

Human Placenta Secretes Apolipoprotein B-100-containing Lipoproteins

Differential, Tissue-specific, Transcriptional Regulation of Apolipoprotein B Secretion by Transforming Growth Factor β

Microsomal Triglyceride Transfer Protein Gene Expression and Triglyceride Accumulation in Hypoxic Human Hearts

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