The DNA sequence of human chromosome 21

Hattori, Masahira; Fujiyama, Asao; Taylor, Todd D.; Watanabe, Hitoshi; Yada, Tetsushi; Park, H.-S.; Toyoda, Atsushi; Ishii, Kazuo; Totoki, Yasushi; Choi, Dong‐Kug; Soeda, Eiichi; Ohki, Masafumi; Takagi, Toshihisa; Sakaki, Yoshiyuki; Taudien, Stefan; Blechschmidt, Karin; Polley, Andreas; Menzel, Uwe; Delabar, J.M.; Kumpf, Kai; Lehmann, Rüdiger; Patterson, David; Reichwald, Kathrin; Rump, Andreas; Schillhabel, M.; Schudy, Andreas; Zimmermann, Wolfgang; Rosenthal, André; Kudoh, Jun; Shibuya, Kazunori; Kawasaki, Kazuhiko; Asakawa, Shuichi; Shintani, Ai; Sasaki, Takashi; Nagamine, Kentaro; Mitsuyama, Susumu; Antonarakis, Stylianos E.; Minoshima, Shinsei; Shimizu, Nobuyoshi; Nordsiek, Gabriele; Hornischer, Klaus; Brandt, Petra; Scharfe, Maren; Schön, Oliver; Desario, A.; Reichelt, Julia; Kauer, Gerhard; Blöcker, Helmut; Ramser, Juliane; Beck, Amy; Klages, Sven; Hennig, Steffen; Rießelmann, L.; Dagand, Emilie; Haaf, Thomas; Wehrmeyer, Silke; Borzym, K.; Gardiner, Katheleen; Nižetić, Dean; Francis, Fiona; Lehrach, Hans; Reinhardt, Richard; Yaspo, Marie–Laure

doi:10.1038/35012518

Cited by 1,083 publications

(568 citation statements)

References 41 publications

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“…the sequences of Neisseria meningitidis [57], D. radiodurans [58], Drosophila melanogaster [59], chromosomes 2 and 4 from Arabidopsis thaliana [60,61], chromosomes 2 and 3 from Plasmodium falciparum [62,63], and chromosomes 21 and 22 from Homo sapiens [64,65] that were recently reported. For the few cases of homologies to these organisms, refer to [37^49].…”

Section: F Tekaia Et Al/febs Letters 487 (2000) 17^30mentioning

confidence: 92%

Genomic Exploration of the Hemiascomycetous Yeasts: 3. Methods and strategies used for sequence analysis and annotation

et al. 2000

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The primary analysis of the sequences for our Hemiascomycete random sequence tag (RST) project was performed using a combination of classical methods for sequence comparison and contig assembly, and of specifically written scripts and computer visualization routines. Comparisons were performed first against DNA and protein sequences from Saccharomyces cerevisiae, then against protein sequences from other completely sequenced organisms and, finally, against protein sequences from all other organisms. Blast alignments were individually inspected to help recognize genes within our random genomic sequences despite the fact that only parts of them were available. For each yeast species, validated alignments were used to infer the proper genetic code, to determine codon usage preferences and to calculate their degree of sequence divergence with S. cerevisiae. The quality of each genomic library was monitored from contig analysis of the DNA sequences. Annotated sequences were submitted to the EMBL database, and the general annotation tables produced served as a basis for our comparative description of the evolution, redundancy and function of the Hemiascomycete genomes described in other articles of this issue. ß

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Section: F Tekaia Et Al/febs Letters 487 (2000) 17^30mentioning

confidence: 92%

Genomic Exploration of the Hemiascomycetous Yeasts: 3. Methods and strategies used for sequence analysis and annotation

et al. 2000

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“…For probes, BAC (bacterial artificial chromosome) clones derived from chromosome 21 were selected from the published chromosome 21 contig 17 and personal communications from Dr Yaspo. BAC clone RP11-2503J9 was obtained from the Max-Planck-Institut fur Molekulare Genetik.…”

Section: Fish (Fluorescence In Situ Hybridization) Analysismentioning

confidence: 99%

Analysis of a t(18;21)(p11.1;p11.1) translocation in a family with schizophrenia

et al. 2009

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“…DCR-2 has been associated with certain facial and dermatoglyphic features, mental retardation, congenital heart disease, as well as duodenal stenosis (Korenberg et al, 1994). Human WDR9 was identified as a transcribed sequence within DCR-2 (Vidal-Taboada et al, 1998;Hattori et al, 2000). The expression of this transcript was further examined recently, and results indicated that human WDR9 is widely expressed in different human adult tissues and several cell lines with tissue-specific transcripts (Ramos et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Expression of the Wdr9 gene and protein products during mouse development

Huang

Rambaldi

Daniels

et al. 2003

Developmental Dynamics

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Human WDR9 has been mapped to chromosome 21, within one of the Down syndrome (DS) critical regions. Here, we study the expression pattern of the murine Wdr9 gene and its protein product. We show that Wdr9 is broadly expressed in the mouse embryo by means of in situ hybridization and immunohistochemistry. Wdr9 expression levels are dynamic during embryonic development as revealed by Northern blot analysis. We further show that WDR9 is a nuclear protein associated with BRG1, a SWI/SNF complex component. We also demonstrate that a polyglutaminecontaining region of the protein functions as a transcriptional activation domain. We propose that WDR9 is a transcriptional regulator involved in chromatin remodeling through the action of two bromodomains and contacts to the SWI/SNF complex. These results may provide a molecular basis for the association of WDR9 with DS.

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The DNA sequence of human chromosome 21

Cited by 1,083 publications

References 41 publications

Genomic Exploration of the Hemiascomycetous Yeasts: 3. Methods and strategies used for sequence analysis and annotation

Genomic Exploration of the Hemiascomycetous Yeasts: 3. Methods and strategies used for sequence analysis and annotation

Analysis of a t(18;21)(p11.1;p11.1) translocation in a family with schizophrenia

Expression of the Wdr9 gene and protein products during mouse development

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