The DNA- and protein-binding properties and cytotoxicity of a new copper(II) hydrazone Schiff base complex

A polynuclear CuIIBiIII complex with antipyrine‐derived Schiff‐base: Preparation, characterization, and biological evaluations

“…1 H NMR (400 MHz, DMSO-d 6 ) δ 13.06 (s, 1H, OH), 9.69 (s, 1H, HC=N), 7.54 (m, 2H, Ar-H), 7.39 (m, 3H, Ar-H), 7.05 (m, 2H, Ar-H), 6.86 (d, J = 8 Hz, 1H, Ar-H), 3.81 (s, 3H, -OCH 3 ), 3.20 (s, 3H, -NCH 3 ), 2.40 (s, 3H, -CH 3 ) (Figure S1). 13…”

“…Copper complexes have attracted more and more attention as anticancer drugs in recent years. One explanation is that their antitumor property is to effectively cleave DNA through oxidation or hydrolysis mechanisms 13,14 . Some studies have indicated that the copper complexes can inhibit proteasomes and induce apoptosis of tumor cells 15–17 .…”

“…One explanation is that their antitumor property is to effectively cleave DNA through oxidation or hydrolysis mechanisms. 13,14 Some studies have indicated that the copper complexes can inhibit proteasomes and induce apoptosis of tumor cells. [15][16][17] Copper also displayed excellent antimicrobial activity.…”