Abstract:MLE (Maleless) protein of D. melanogaster is a conserved helicase involved in a wide range of gene expression regulation processes. MLE ortholog, named DHX9, has been found in many higher eukaryotes, including humans. It is involved in such diverse processes as maintenance of genome stability, replication, transcription, splicing, editing and transport of cellular and viral RNAs, and translation regulation. Some of these functions have been studied in detail to date, but the most of them remain uncharacterized… Show more
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