The diverse methods of bleomycin delivery in cutaneous warts: A literature review

Kaul, Subuhi; Kaur, Ishmeet; Jakhar, Deepak; Edigin, Ehizogie; Caldito, Elena Gonzalez

doi:10.1111/dth.14401

Cited by 7 publications

(11 citation statements)

References 48 publications

(297 reference statements)

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“…Bleomycin is the generic name of a group of cytotoxic sulfur‐glycopeptide antibiotics produced by Streptomyces verticillus , 21 which inhibits DNA synthesis and heightens the formation of microthromboses 23 . Although the mean cure rate with this treatment is 83.37%, 24 and it is highly effective in the treatment of resistant plantar warts, 19,25 it can have adverse effects on the patient 26 .…”

Section: Discussionmentioning

confidence: 99%

“…Among invasive treatment options, multi-puncture or infiltration may be performed with bleomycin, 16,[19][20][21] hypersaline solution, or 0.9% saline solution 22 using Dermojet®, a needleless system consisting of a metal syringe fitted with a piston, a spring and a lever, which allows liquid to be introduced into the skin at a pressure of 100 kg/cm, provoking cell damage.…”

Section: Discussionmentioning

confidence: 99%

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Treatment efficacy of 0.9% saline and mepivacaine infiltration with Dermojet® in eliminating plantar warts

Silvia

Gracia-Sánchez

et al. 2023

J of Cosmetic Dermatology

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Background: Plantar warts are benign, epidermal neoformations, viral, and easily transmitted. Although 30% of these warts disappear spontaneously, the American Association of Dermatology recommends treatment if they cause pain or bleeding. Objectives:The aim of this study was to determine the efficacy of Dermojet® infiltration using a solution composed of equal parts of 0.9% saline and 2% mepivacaine in the treatment of plantar warts, and to identify the type of necrosis achieved at 7-10 days after the infiltration (M1 sample) and at 15-17 days (M2 sample). Method:In this analytical prospective observational study, 102 histories were reviewed by the same researcher. The patients were treated with this technique at four private podiatry clinics.Results: A total of 61.8% of the patients were male. The patients' mean age was 26.6 ± 14.10 years. A total percentage of 78.4% of the patients achieved complete elimination of the lesion by the second evaluation and after a single infiltration.Bivariate analysis revealed a significant inverse relationship between treatment efficacy and a history of previous disease (p < 0.001) and the period of evolution of the lesion (p < 0.001; 95% CI [0.78-7.91]). Multivariate linear regression analysis revealed an association with the number of evaluation sessions (p < 0.001) and with previous illnesses (p = 0.014). A total percentage of 82.35% presented partial necrosis in the M1 sample and 76.92% had complete necrosis in the M2 sample.Conclusions: In 78.4% of the patients considered, the plantar warts treated disappeared after a single infiltration. The variables associated with treatment efficacy were the number of follow-up visits and the existence of associated diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Treatment efficacy of 0.9% saline and mepivacaine infiltration with Dermojet® in eliminating plantar warts

Silvia

Gracia-Sánchez

et al. 2023

J of Cosmetic Dermatology

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“…Verruca vulgaris can occur in any part of the skin, and it is more common in children due to skin trauma, with an incidence of about 5% 4 . Traditional treatments include CO 2 laser, microwave, liquid nitrogen cryotherapy, and photodynamic therapy 5,6 …”

Section: Discussionmentioning

confidence: 99%

“…5,6 With the continuous development of laser, pulsed dye laser has been applied to the treatment of verruca vulgaris for many years, but there are relatively few reports of pulsed dye laser for verruca vulgaris. [5][6][7][8] There are little reports comparing the advantages and disadvantages of the common clinical treatment three methods of 595 nm pulsed dye laser, microwave tissue coagulation, and liquid nitrogen freezing for the treatment of verruca vulgaris, and also little reports evaluating the efficacy of 595 nm pulsed dye laser for the treatment of verruca vulgaris warts using dermoscopy. Through this comparative study of the three treatment methods, we concluded the following: The efficacy of the 595-nm pulsed dye laser treatment…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy evaluation of 595‐nm pulsed dye lasers, microwave tissue coagulation, and liquid nitrogen cryotherapy in the treatment of verruca vulgaris in children

Zhuang

You

Zhang

et al. 2022

J of Cosmetic Dermatology

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Objective To evaluate the clinical efficacy and safety of 595‐nm pulsed dye laser in the treatment of verruca vulgaris in children and to compare the efficacy of this method against two other methods, microwave tissue coagulation and liquid nitrogen cryotherapy. Methods A total of 90 children being treated in the dermatology outpatient department of our hospital from 2019 to 2021 were selected and divided into three groups: the treatment group A (n = 30, treated with a 595‐nm pulsed dye laser), treatment group B (n = 30, treated with microwave tissue coagulation), and treatment group C (n = 30, treated with liquid nitrogen cryotherapy). All the patients in the treatment group A, treatment group B, and treatment group C were treated once every two weeks, with a maximum of six treatments. Results The response rate of the treatment group A was 93.3%, which was higher than the 83.3% rate of treatment group B and the 66.7% rate of treatment group C. The average treatment times of the treatment group A (2.45 ± 1.10) were lower than group B (3.51 ± 0.98) and group C (4.63 ± 0.96). The adverse reaction rate in the treatment group A (16.7%) was significantly lower than that in treatment group B (56.7%) and treatment group C (63.3%). The differences were statistically significant (all p < 0.05). Conclusions The 595‐nm pulsed dye laser is safe and seems to be the most effective treatment for verruca vulgaris in children. Further high‐level clinical trial is warranted to verify our results.

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“…According to Kaul et al 9 . it is unclear whether there is any difference between various methods of multipuncture needling and microneedling, and that both needling and microneedling are equally effective.…”

Section: Reportmentioning

confidence: 99%

Skin needling with 100% trichloroacetic acid vs. needling with bleomycin in the treatment of recalcitrant cutaneous warts

Mohta

Ghiya

Mehta

et al. 2022

Clinical and Experimental Dermatology

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Summary The treatment of warts has always been a challenging prospect for dermatologists. In some cases, these warts can become resistant or recalcitrant to treatment. Although a plethora of therapeutic and destructive options is available for wart management, to date no treatment has been found to be completely effective because none of the agents induce specific antiviral immunity. We conducted a study to evaluate the efficacy and safety of skin needling with topical 100% trichloroacetic acid (TCA) against the same type of skin needling with bleomycin in patients with recalcitrant cutaneous warts. In total, 33 (63.5%) patients in the TCA group and 35 (81.4%) in the bleomycin group had complete clearance of all the warts, which was not statistically significant (P = 0.13). There was also no statistically significant difference between the treated and untreated warts in the bleomycin group, whereas in the TCA group there was a significantly higher response rate in the treated warts. The most common adverse event (AE) in both groups was transient procedure site pain. We found that the use of needling plus TCA leads to a faster resolution of warts compared with needling plus bleomycin, with a comparable safety profile. Additionally, we found that TCA is superior to bleomycin for management of multiple warts. However, needling with either TCA or bleomycin has excellent and fairly comparable efficacy, and these methods should be used for the management of multiple or recalcitrant warts, as they have minimal AEs and recurrence rates.

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The diverse methods of bleomycin delivery in cutaneous warts: A literature review

Cited by 7 publications

References 48 publications

Treatment efficacy of 0.9% saline and mepivacaine infiltration with Dermojet® in eliminating plantar warts

Treatment efficacy of 0.9% saline and mepivacaine infiltration with Dermojet® in eliminating plantar warts

Clinical efficacy evaluation of 595‐nm pulsed dye lasers, microwave tissue coagulation, and liquid nitrogen cryotherapy in the treatment of verruca vulgaris in children

Skin needling with 100% trichloroacetic acid vs. needling with bleomycin in the treatment of recalcitrant cutaneous warts

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