The diverse functions of histone acetyltransferase complexes

Carrozza, Michael J.; Utley, Rhea T.; Workman, Jerry L.; Côté, Jacques

doi:10.1016/s0168-9525(03)00115-x

Cited by 493 publications

(438 citation statements)

References 69 publications

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“…Both ING1 and ING2 are components of Sin3-HDAC complexes (Loewith et al, 2001;Kuzmichev et al, 2002;Doyon et al, 2006), whereas ING3 is a subunit of TIP60 complexes (Loewith et al, 2000;Gong et al, 2005). It is worth to note that a tetrameric TIP60 complex core, containing EAF6 and Epc1/2, is very similar to ING4 and ING5 complexes (Carrozza et al, 2003;. Yng1 and Yng2 are two yeast ING proteins.…”

Section: Moz and Morf As Catalytic Subunits Of Quartet Complexesmentioning

confidence: 98%

MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells

2007

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Genes of the human monocytic leukemia zinc-finger protein MOZ (HUGO symbol, MYST3) and its paralog MORF (MYST4) are rearranged in chromosome translocations associated with acute myeloid leukemia and/or benign uterine leiomyomata. Both proteins have intrinsic histone acetyltransferase activity and are components of quartet complexes with noncatalytic subunits containing the bromodomain, plant homeodomain-linked (PHD) finger and proline-tryptophan-tryptophan-proline (PWWP)-containing domain, three types of structural modules characteristic of chromatin regulators. Although leukemia-derived fusion proteins such as MOZ-TIF2 promote self-renewal of leukemic stem cells, recent studies indicate that murine MOZ and MORF are important for proper development of hematopoietic and neurogenic progenitors, respectively, thereby highlighting the importance of epigenetic integrity in safeguarding stem cell identity.

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Section: Moz and Morf As Catalytic Subunits Of Quartet Complexesmentioning

confidence: 98%

MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells

2007

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“…Figure 2: Sites of histone acetylation (Carrozza et al, 2003) Histone acetylation is reversible, with histone deacetylation being faciliated by histone deacetylases (HDACs). In euchromation, histone acetylation is enriched, whereas in heterochromatin, histones are hypoacetylated.…”

Section: Histone Modifications Histone Variants and Chromatin Remodementioning

confidence: 99%

“…HATs are divided into five families: Gcn5-related HATs, p300/CBP HATs, the general transcription factor HATs, nuclear hormone receptor-related HATs and the MYST family of HATs (Carrozza et al, 2003). The MYST family is named for its founding members MOZ, Ybf2/Sas3, Sas2 and Tip60.…”

Section: The Myst Family Of Hatsmentioning

confidence: 99%

Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60

et al. 2009

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“…The histone deacetylase RPD3b (reduced potassium dependency 3b) was found to interact with COI1 in yeast two-hybrid screens, suggesting that it might be a COI1 target [55]. Histone deacetylation npg is involved in chromatin remodeling and is believed to reduce the transcription of the genes in the region where chromatin is modified [57]. Therefore, it is likely that SCF COI1 -mediated modification or breakdown of RPD3b will derepress JA-dependent gene expression.…”

Section: Members Of the Ubiquitination System Are Implicated In Plantmentioning

confidence: 99%

Ubiquitination-mediated protein degradation and modification: an emerging theme in plant-microbe interactions

et al. 2006

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Post-translational modification is central to protein stability and to the modulation of protein activity. Various types of protein modification, such as phosphorylation, methylation, acetylation, myristoylation, glycosylation, and ubiquitination, have been reported. Among them, ubiquitination distinguishes itself from others in that most of the ubiquitinated proteins are targeted to the 26S proteasome for degradation. The ubiquitin/26S proteasome system constitutes the major protein degradation pathway in the cell. In recent years, the importance of the ubiquitination machinery in the control of numerous eukaryotic cellular functions has been increasingly appreciated. Increasing number of E3 ubiquitin ligases and their substrates, including a variety of essential cellular regulators have been identified. Studies in the past several years have revealed that the ubiquitination system is important for a broad range of plant developmental processes and responses to abiotic and biotic stresses. This review discusses recent advances in the functional analysis of ubiquitination-associated proteins from plants and pathogens that play important roles in plant-microbe interactions.

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The diverse functions of histone acetyltransferase complexes

Cited by 493 publications

References 69 publications

MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells

MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells

Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60

Ubiquitination-mediated protein degradation and modification: an emerging theme in plant-microbe interactions

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