The divergent impact of catechol-O-methyltransferase ( COMT ) Val 158 Met genetic polymorphisms on executive function in adolescents with discrete patterns of childhood adversity

Zhang, Huihui; Li, Jie; Yang, Bei; Tao, Jianhua; Long, Zhouting; Xing, Qiquan; Шао, Ди; Bai, Huayu; Sun, Jiwei; Cao, Fenglin

doi:10.1016/j.comppsych.2017.11.004

Cited by 8 publications

(9 citation statements)

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“…The subsample of ELA–executive functioning association that was categorized as threat or deprivation (n = 187) was analyzed in 56 of 91 articles (61.5%), which represented 49 cohorts and 25 679 unique individuals. The cognitive flexibility analysis included the association with 15 deprivation and 23 threat effect sizes; the inhibitory control analysis included 52 deprivation and 41 threat effect sizes; and the working memory analysis included 33 deprivation and 23 threat effect sizes.…”

Section: Resultsmentioning

confidence: 97%

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Associations of Early-Life Threat and Deprivation With Executive Functioning in Childhood and Adolescence

Johnson

Policelli

et al. 2021

JAMA Pediatr

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IMPORTANCEMany studies have demonstrated an association between early-life adversity (ELA) and executive functioning in children and adolescents. However, the aggregate magnitude of this association is unknown in the context of threat and deprivation types of adversity and various executive functioning domains.OBJECTIVE To test the hypothesis that experiences of deprivation are more strongly associated with reduced executive functioning compared with experiences of threat during childhood and adolescence.DATA SOURCES Embase, ERIC, MEDLINE, and PsycInfo databases were searched from inception to December 31, 2020. Both forward and reverse snowball citation searches were performed to identify additional articles.STUDY SELECTION Articles were selected for inclusion if they (1) had a child and/or adolescent sample, (2) included measures of ELA, (3) measured executive functioning, (4) evaluated the association between adversity and executive functioning, (5) were published in a peer-reviewed journal, and (6) were published in the English language. No temporal or geographic limits were set. A 2-reviewer, blinded screening process was conducted.DATA EXTRACTION AND SYNTHESIS PRISMA guidelines were used to guide data extraction and article diagnostics (for heterogeneity, small study bias, and p-hacking). Article quality was assessed, and data extraction was performed by multiple independent observers. A 3-level meta-analytic model with a restricted maximum likelihood method was used. Moderator analyses were conducted to explore heterogeneity. MAIN OUTCOMES AND MEASURESPrimary outcomes included measures of the 3 domains of executive functioning: cognitive flexibility, inhibitory control, and working memory.RESULTS A total of 91 articles were included, representing 82 unique cohorts and 31 188 unique individuals. Deprivation, compared with threat, was associated with significantly lower inhibitory control (F 1,90 = 5.69; P = .02) and working memory (F 1,54 = 5.78; P = .02). No significant difference was observed for cognitive flexibility (F 1,36 = 2.38; P = .12). The pooled effect size of the association of inhibitory control with deprivation was stronger (Hedges g = −0.43; 95% CI, −0.57 to −0.29) compared with threat (Hedges g = −0.27; 95% CI, −0.46 to −0.08). The pooled effect size of the association of working memory with deprivation was stronger (Hedges g = −0.54; 95% CI, −0.75 to −0.33) compared with threat (Hedges g = −0.28; 95% CI, −0.51 to −0.05).CONCLUSIONS AND RELEVANCE Experiences of both threat and deprivation in childhood and adolescence were associated with reduced executive functioning, but the association was stronger for exposure to deprivation. Efforts to address the consequences of ELA for development should consider the associations between specific dimensions of adversity and specific developmental outcomes.

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Section: Resultsmentioning

confidence: 97%

“…A total of 106 relevant articles were included; however, 15 articles were identified as redundant in the presence of more relevant articles that used the same sample. After the removal of redundancies, 91 articles were included in the meta-analysis. Eleven of these articles were identified from the references of included articles.…”

Section: Resultsmentioning

confidence: 99%

Associations of Early-Life Threat and Deprivation With Executive Functioning in Childhood and Adolescence

Johnson

Policelli

et al. 2021

JAMA Pediatr

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“…Given there were only a small number of TT genotypes, and the TT genotype codes for the similar activity form of the enzyme as GT genotype ( Lee et al, 2005 ), these two genotypes were pooled for the purpose of analyses, which is common in previous studies (e.g., Windle and Mrug, 2015 ; Zhang H. et al, 2017 ). Bivariate Pearson correlations were conducted to assess the associations between observed variables in the present study.…”

Section: Methodsmentioning

confidence: 99%

“…During the past decade, there have been a number of studies have exmined the risk factors for aggressive behavior in adolescence. Previous research has demonstrated that individual differences in such behaviors have important genetic as well as environmental underpinnings ( Caspi et al, 2002 ; Brendgen et al, 2006 ; Craig and Halton, 2009 ; McDermott et al, 2009 ; Johansson et al, 2012 ; Zhang Y. et al, 2017 ), and a large body of the available evidence indicated that catecholaminergic system genes may interact with a variety of environmental exposure in predicting aggressive behavior ( Perroud et al, 2010 ; Hygen et al, 2015 ; Zhang H. et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…The human COMT gene is located on chromosome 22q 11.2 and encodes COMT, the major metabolic enzyme for catecholamines (adrenalin, noradrenaline, and dopamine). In most studies, the COMT gene polymorphism of particular interest was referred to as the Val158Met (rs4680) locus, a common polymorphism within the coding sequence of COMT ( Montirosso et al, 2016 ; Sheikh et al, 2017 ; Zhang H. et al, 2017 ; Minassian et al, 2018 ). However, it should be noted that among Asians, including Chinese populations from which the current study’s sample was drawn, a second common functional single nucleotide polymorphism at which the variant between a G and T causes an alanine -to-serine (Ala/Ser) substitution, also exists in exon 4.…”

Section: Introductionmentioning

confidence: 99%

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Interacting Effect of Catechol-O-Methyltransferase (COMT) and Monoamine Oxidase A (MAOA) Gene Polymorphisms, and Stressful Life Events on Aggressive Behavior in Chinese Male Adolescents

Wang

Deater‐Deckard

et al. 2018

Front. Psychol.

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Numerous studies have demonstrated that both catechol-O-methyltransferase (COMT) gene and monoamine oxidase A (MAOA) gene have been involved in aggressive behavior, as have stressful life events (SLEs). However, most of available evidence was based upon single gene or single gene–environment design, which is limited in accounting for the variance of aggressive behavior, a complex phenotype. This study examined the possible gene × gene × environment interactions between SLE (interpersonal problems and academic pressure) and two genetic polymorphisms (MAOA T941G and COMT Ala22/72Ser) correlated with aggressive behaviors in a sample of 658 Chinese male adolescents. Mothers and teachers reported on adolescents’ aggressive behavior using Achenbach’s Child Behavior Checklist and Teacher Report Form, respectively. Adolescents completed Self-Rating Life Events Checklist. Saliva samples were collected for DNA analysis. The results revealed no main effects of MAOA T941G and COMT Ala22/72Ser polymorphisms on male adolescents’ aggressive behaviors. However, a two-way interactive effect of interpersonal problems and MAOA T941G genotype on teacher-reported aggressive behavior was observed: adolescents with lower activity of MAOA T allele, but not those with MAOA G allele, exhibited greater aggressive behavior with an increase in interpersonal problems. A three-way interaction among COMT Ala22/72Ser and MAOA T941G polymorphisms, and SLE in the academic pressure on aggressive behavior was also identified. Among adolescents with lower activity of COMT GT/TT genotype and MAOA T allele, the higher level of academic pressure was significantly linked with an amplification of aggressive behavior, whereas this association didn’t exist among those with other genotypes. The present study presents the first evidence of COMT × MAOA × SLE interaction effect on male adolescents’ aggressive behavior, highlights the importance of considering distinct domains of stressful events and information bias when examining the effect of MAOA and COMT on aggressive behavior, and thereby contributes to MAOA gene-aggression and COMT gene-aggression literature.

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Genetic Predictors of Destructive and Constructive Forms of Digital Behavior of Young Adults

Абакумова

Ермаков

Denisova

et al. 2022

International Scientific Siberian Transport Forum TransSiberia - 2021

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The divergent impact of catechol-O-methyltransferase ( COMT ) Val 158 Met genetic polymorphisms on executive function in adolescents with discrete patterns of childhood adversity

Cited by 8 publications

References 73 publications

Associations of Early-Life Threat and Deprivation With Executive Functioning in Childhood and Adolescence

Associations of Early-Life Threat and Deprivation With Executive Functioning in Childhood and Adolescence

Interacting Effect of Catechol-O-Methyltransferase (COMT) and Monoamine Oxidase A (MAOA) Gene Polymorphisms, and Stressful Life Events on Aggressive Behavior in Chinese Male Adolescents

Genetic Predictors of Destructive and Constructive Forms of Digital Behavior of Young Adults

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