The Divalent Elements Changes in Early Stages of Chronic Kidney Disease

Kung, Wan‐Ju; Shih, Ching‐Tang; Lee, Chien-Hung; Lin, Ching‐Chiang

doi:10.1007/s12011-017-1228-3

Cited by 15 publications

(8 citation statements)

References 36 publications

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“…As CKD progresses, GFR decreases, leading to an imbalance of certain trace elements, and higher CKD stages are associated with increased levels of Cu and decreased levels of Zn ( 153 ). This suggests the Cu/Zn ratio could be used as a marker for early and late detection of renal failure ( 154 ).…”

Section: Discussionmentioning

confidence: 99%

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Xie¹,

Liu²,

Zhang³

et al. 2022

Ann Transl Med

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Background and Objective: Chronic kidney disease (CKD) is an important public health concern.With the decline of renal function, CKD patients gradually progress to end-stage kidney disease and need to undergo dialysis or kidney transplantation to maintain life, bringing a heavy economic burden to the family and society. Therefore, it is necessary to effectively prevent and delay the progression of CKD. Essential trace elements play an indispensable role in CKD, and the objective of this study is to systematically review their benefits in the disease and summarize the risks of their excess.Methods: The keywords "trace elements", "chronic kidney disease", "dialysis", "inflammation", and "fibrosis" and their combinations were used to search for relevant literature published in the PubMed database and Web of Science. We then summarized the role of trace element abnormalities in CKD patients in anemia, oxidative stress, inflammation, and chronic fibrosis, and the risk of their excess.

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Section: Discussionmentioning

confidence: 99%

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Xie¹,

Liu²,

Zhang³

et al. 2022

Ann Transl Med

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“…Zinc is essential for the human body and is involved in many catalytic, structural, and regulatory activities, including the replication of DNA, energy metabolism, maintenance of protein structure, body growth and development 39 , 40 . Multiple epidemiological studies have found that Zn deficiency may have harmful impacts on human health, such as inducing CKD 33 , 34 . However, in our study, the highest exposure to Zn was associated with an increased risk of hazardous renal performance, which provides potential evidence for the U-shaped association between Zn and renal health.…”

Section: Discussionmentioning

confidence: 99%

The association between urinary metals/metalloids and chronic kidney disease among general adults in Wuhan, China

Huang,

Wan,

Zhang

et al. 2023

Sci Rep

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The relation between exposure to single metal/metalloid and the risk of chronic kidney disease (CKD) remains unclear. We aimed to determine the single and mixed associations of 21 heavy metals/metalloids exposure and the risk of CKD. We performed a cross-sectional study that recruited 4055 participants. Multivariate logistic regression, linear regression and weighted quantile sum (WQS) regression were conducted to explore the possible effects of single and mixed metals/metalloids exposure on the risk of CKD, the risk of albuminuria and changes in the estimated glomerular filtration rate (eGFR). In single-metal models, Cu, Fe, and Zn were positively associated with increased risks of CKD (P-trend < 0.05). Compared to the lowest level, the highest quartiles of Cu (OR = 2.94; 95% CI: 1.70, 5.11; P-trend < 0.05), Fe (OR = 2.39; 95% CI: 1.42, 4.02; P-trend < 0.05), and Zn (OR = 2.35; 95% CI: 1.31, 4.24; P-trend < 0.05) were associated with an increased risk of CKD. After multi-metal adjustment, the association with the risk of CKD remained robust for Cu (P < 0.05). Weighted quantile sum regression revealed a positive association between mixed metals/metalloids and the risk of CKD, and the association was largely driven by Cu (43.7%). Specifically, the mixture of urinary metals/metalloids was positively associated with the risk of albuminuria and negatively associated with eGFR.

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“…Recently, zinc de ciency has been found to speci cally upregulate the expression of nicotinamide adenine dinucleotide phosphate oxidase 2 in renal tubular epithelial cells, promote oxidative stress, and cause kidney damage [23]. In CKD patients, the serum zinc was decreased, which was signi cantly negatively correlated with the serum phosphorus level, positively correlated with the serum total protein, albumin and serum calcium levels [24]. Correcting the low level serum zinc could help to delay the progression of CKD and prevent its complications [25].…”

Section: Discussionmentioning

confidence: 99%

Associations Between Serum Copper, Zinc and Copper/Zinc Ratio and Risk of Chronic Kidney Disease: A cross-sectional analysis of the NHANES 2011-2016

Liu

et al. 2022

Preprint

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Several studies have indicated an association between serum copper and zinc and chronic kidney disease, while there was antagonism between serum copper and zinc, and the serum copper/zinc ratio was more accurate than detecting the two elements alone. This study aims to evaluate the associations of serum copper, zinc and copper/zinc rate with the risk of CKD using the 2011–2016 National Health and Nutritional Examination Surveys (NHANES). A total of 7764 participants were included in the analyses. Weighted multivariable logistic regression was applied to investigate the association between serum zinc and copper level and CKD after adjusting for potential confounders. A restricted cubic spline (RCS) to explore the relationships and trend between copper/zinc ratio and the risk of developing CKD. Machine learning of the XGBoost algorithm model was used to assess each variable’s contribution to the risk of having CKD. In this study, when the serum copper/zinc level decreased to less than 1.2, the risk of having CKD was reduced to 0.57 (95%CI, 0.39–0.84, p = 0.006). The RCS model showed a negative liner correlation between serum copper/zinc ratio and CKD risk (p < 0.001 and the value of nonlinear equal to 0.06), and when the ratio was lower than 1.49, the OR of having CKD begins to be lower than 1 and shows a rapidly increasing trend. In the XGBoost model, besides the glomerular filtration rate, the Copper/Zinc ratio was the most relative variable in our study. Therefore, the copper/zinc ratio would be a relatively important risk factor for predicting having CKD, and further researches are needed to explore the potential mechanism between copper/zinc and CKD.

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The Divalent Elements Changes in Early Stages of Chronic Kidney Disease

Cited by 15 publications

References 36 publications

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

Benefits and risks of essential trace elements in chronic kidney disease: a narrative review

The association between urinary metals/metalloids and chronic kidney disease among general adults in Wuhan, China

Associations Between Serum Copper, Zinc and Copper/Zinc Ratio and Risk of Chronic Kidney Disease: A cross-sectional analysis of the NHANES 2011-2016

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