The Diurnal Rhythm of Plasma Aldosterone, Plasma Renin Activity, Plasma Cortisol and Serum Growth Hormone and Subnormal Responsiveness of Aldosterone to Angiotensin-II in the Patients with Normotensive Acromegaly

Ichikawa, Shûichi; Sakamaki, Tatsuya; Tonooka, Sachiko; Sugai, Yoshiro

doi:10.1507/endocrj1954.23.75

Cited by 9 publications

(5 citation statements)

References 7 publications

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“…The diurnal rhythm pattern of PA was just the same as in the normal subjects in our previous report (Ichikawa et al, 1976). On the other hand, a diurnal rhythm of PRA was obscure except in one case in the present series, and PA and PRA did not run parallel in the remaining 7 cases.…”

Section: Discussionsupporting

confidence: 80%

“…Study of the diurnal rhythm of plasma aldosterone (PA) and plasma renin activity (PRA) was performed as previously described (Ichikawa et al, 1976). The patients were kept in supine position except at meal time for less than 15min.…”

Section: Methodsmentioning

confidence: 99%

“…However, the urinary excretion and the plasma level of aldosterone in the patients have subsequently been reported with wide variation (Wolff et al, 1957;Laragh, 1962;Cox et al, 1964;Sanders and Melby, 1964;Hickie and Lazarus, 1971;Kubo, 1971;Nicholls et al, 1974). Because of wide diurnal variation of aldosterone levels as pointed out by many investigators in normal subjects (Williams et al, 1972;Katz et al, 1972 andVagnucci et al, 1974;Armbruster et al, 1975;Ichikawa et al, 1976), a single determination of plasma aldosterone levels may give a misleading result. The present study was attempted in order to observe the diurnal pattern of plasma aldosterone in congestive heart failure, especially in relation to the plasma renin activity.…”

mentioning

confidence: 99%

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The diurnal rhythm of plasma aldosterone and plasma renin activity in patients with congestive heart failure.

et al. 1977

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Section: Discussionsupporting

confidence: 80%

Section: Methodsmentioning

confidence: 99%

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The diurnal rhythm of plasma aldosterone and plasma renin activity in patients with congestive heart failure.

et al. 1977

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“…Blood presure and aldosterone responses to angiotensin I1 and angiotensin antagonists (Moore et al, 1980;Ogihara et al, 1979;Hauger-Klevene, 1975;Ichikawa et al, 1976) are similar to those in sodium-loaded normal subjects. There is no difference between hypertensive and normotensive acromegalics.…”

Section: The Renin-angiotensin Systemmentioning

confidence: 78%

“…Thus, basal plasma renin and angiotensin I1 concentrations are not suppressed in proportion to concentrations seen in other conditions associated with sodium retention such as Conn's syndrome. The reason for this is unclear and some aspects relating to this have been discussed earlier.Blood presure and aldosterone responses to angiotensin I1 and angiotensin antagonists (Moore et al, 1980; Ogihara et al., 1979;Hauger-Klevene, 1975;Ichikawa et al, 1976) are similar to those in sodium-loaded normal subjects. There is no difference between hypertensive and normotensive acromegalics.…”

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confidence: 88%

Hormones and Hypertension

Fraser

Davies

Connell

1989

Clinical Endocrinology

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The importance of changes in hormone secretion in human hypertension is a complex problem and too large to be dealt with in uniform detail in a short review. The subject encompasses not only the effects on blood pressure of primary endocrine disorders but also hormonal changes secondary to increased blood pressure. Some aspects are more fully understood than others and have been the subjects of relatively recent detailed reviews. Where this is the case, the current review has summarized the present position and cited reviews and key papers, in order to reserve space for more controversial and less well understood conditions such as the hypertension of growth hormone, thyroid hormone or glucocorticoid excess. CORTICOSTEROIDSThe human adrenal cortex synthesizes and secretes a large number of steroid hormones, biosynthetically interrelated with each other and with qualitatively and quantitatively different biological activities. The two major categories of compound are the adrenal androgens (androstenedione, dehydroepiandrosterone and testosterone) which, as far as is known, are not important in blood pressure control and will not be considered further (although there exist experimental models of hypertension which may be androgendependent), and the corticosteroids. These C21 steroids of the pregnane series exert two main types of action, mineralocorticoid and glucocorticoid effects, and excess secretion of either has widespread repercussions, particularly for neuromuscular function and the control of salt and water metabolism. Mineralocorticoids act mainly on the distal nephron via specific receptor activation to promote sodium reabsorption (with associated changes in extracellular fluid and plasma volume) and increased potassium and proton excretion, so that excess activity is characterized by hypokalaemia and a metabolic alkalosis. Aldosterone is the major mineralocorticoid in man but deoxycorticosterone (DOC) and corticosterone also have significant activity. More recently discovered compounds-18-hydroxy DOC, 18-oxocortisol and several compounds modified at position 19 (19-hydroxy or 19-nor)-may also contribute to the total mineralocorticoid action of the adrenocortical secretion (see review by Fraser & Padfield, 1985). Cortisol is the major human glucocorticoid. Glucocorticoids promote liver glycogen and protein synthesis but are catabolic in most other tissues, increasing lipolysis and protein R. Fraser et al.breakdown and reducing glucose uptake from the circulation. However, the kidney also possesses specific glucocorticoid receptors and, under experimental conditions, glucocorticoids can be shown to promote both natriuresis and kaliuresis, at least partly by raising glomerular filtration rate (GFR) and also to modulate Na+-H+ exchange in the proximal nephron (Davis & Howell, 1953;Mahnensmith & Aronson, 1985; Kinsella et al., 1985). Excess of either mineralocorticoid or glucocorticoid activity is associated with hypertension.The control of adrenocortical function is similarly complex and the subject of sev...

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Circadian as well as circannual rhythms of circulating aldosterone have decreased amplitude in aging women

Cugini

Scavo

Centanni

et al. 1983

J Endocrinol Invest

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Age differences in the characteristics of the circadian rhythm in circulating radioimmunoassayable aldosterone were studied on nine 20 to 26 year-old and ten 70 to 78 year-old women and ten 23 to 26 year old and ten 70 to 80 year old men in Würzburg, West Germany. These diurnally active-nocturnally resting subjects were sampled every 3 hours for 15 hours. A classical analysis of variance and a multivariate analysis of rhythm characteristics revealed major effects of age exerted on the circadian aldosterone amplitude in women (p = 0.003) but not in concomitantly sampled men. These observations complement the study of circadian and circannual rhythms in 8 young adults (15-21 years), 10 mature adults (29-36 years) and 10 post-menopausal (44-59 years) North American women, sampled at 100 minute intervals for 24 hours, once in each season, and document that the adrenocortical aldosterone-producing system remains rhythmic with at least two frequencies up to the late decades of human life, although in women it may be characterized by a reduction in the extent of spectral change after 70 years of age.

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The Diurnal Rhythm of Plasma Aldosterone, Plasma Renin Activity, Plasma Cortisol and Serum Growth Hormone and Subnormal Responsiveness of Aldosterone to Angiotensin-II in the Patients with Normotensive Acromegaly

Cited by 9 publications

References 7 publications

The diurnal rhythm of plasma aldosterone and plasma renin activity in patients with congestive heart failure.

The diurnal rhythm of plasma aldosterone and plasma renin activity in patients with congestive heart failure.

Hormones and Hypertension

Circadian as well as circannual rhythms of circulating aldosterone have decreased amplitude in aging women

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