The diuretic effect of adding aminophylline or theophylline to furosemide in pediatric populations: a systematic review

Synthesis and Biological Activity Evaluation of Novel Chalcone Analogues Containing a Methylxanthine Moiety and Their N-Acyl Pyrazoline Derivatives

“…For example, caffeine (1,3,7-trimethylxanthine) and theophylline (1,3-dimethylxanthine) which are ingredients in tea, coffee, and some other beverages, are two typical natural methylxanthines and play important roles in traditional medicines . Caffeine can not only antagonize adenosine receptors and inhibit the activity of phosphodiesterase to show neurostimulatory actions, , but also be used as a vasodilator and a drug to treat renal disease. , As for theophylline, it can be adapted to treat respiratory diseases due to its bronchodilator action and is also used as a cardiac stimulator and diuretic. ,− …”

Design, synthesis and biological evaluation of tetrahydroquinoxaline sulfonamide derivatives as colchicine binding site inhibitors

“…26 Subsequently, sulfonamide derivatives were found to act as diuretics, such as carbonic anhydrase inhibitors (acetazolamide), Na + -Cl − cotransport inhibitors (hydrochlorothiazide), Na + -K + -2Cl − cotransport inhibitors (furosemide). 27,28 Moreover, sulfonamide derivatives also act as hypoglycemic drugs to promote insulin secretion (glimepiride). 29 In recent decades, some sulfonamides have been developed as anticancer agents, such as topoisomerase II poison amsacrine, HDAC inhibitor belinostat and JAK2/FLT3 dual inhibitor fedratinib (Fig.…”