The Distribution of<sup>198</sup>Au Injected Intravenously as a Colloid and in Solution

Säterborg, N.-E.

doi:10.3109/02841867309130417

Cited by 6 publications

(4 citation statements)

References 17 publications

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Section: Discussionmentioning

confidence: 63%

“…Especially the early distribution study by Säterborg [40] shows comparable data; they also used radio-labelled GNP (25nm) which are comparable to the 18nm GNP used in our study. Their results are confirmation of our investigations as the highest accumulation is detected in the liver [40]. Another study investigated the biodistribution of GNP of different sizes [41]; however, it is difficult to compare it with our results because it is not clear where the injected GNP ended up.…”

Section: Discussionmentioning

confidence: 63%

See 1 more Smart Citation

Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration

Hirn

Semmler‐Behnke

Schleh

et al. 2011

European Journal of Pharmaceutics and Biopharmaceutics

516

373

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Gold nanoparticles (GNP) provide many opportunities in imaging, diagnostics, and therapies of nanomedicine. Hence, their biokinetics in the body are prerequisites for specific tailoring of nanomedicinal applications and for a comprehensive risk assessment.We administered 198 Au-radio-labelled monodisperse, negatively charged GNP of five different sizes (1.4, 5, 18, 80, 200nm) and 2.8nm GNP with opposite surface charges by intravenous injection into rats. After 24 h the biodistribution of the GNP was quantitatively measured by gamma-spectrometry.The size and surface charge of GNP strongly determine the biodistribution. Most GNP accumulated in the liver increased from 50% of 1.4nm GNP to > 99% of 200nm GNP. In contrast, there was little size dependent accumulation of 18nm to 200nm GNP in most other organs. However, for GNP between 1.4nm and 5nm the accumulation increased sharply with decreasing size; i.e. a linear increase with the volumetric specific surface area. The differently charged 2.8nm GNP led to significantly different accumulations in several organs.We conclude that the alterations of accumulation in the various organs and tissues, depending on GNP size and surface charge, are mediated by dynamic protein binding and exchange. A better understanding of these mechanisms will improve drug delivery and dose estimates used in risk assessment.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 63%

Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration

Hirn

Semmler‐Behnke

Schleh

et al. 2011

European Journal of Pharmaceutics and Biopharmaceutics

516

373

View full text Add to dashboard Cite

show abstract

“…Additionally, their half-lives are optimal for production, shipping, and administration. Beyond the use of colloidal gold radionuclide 198 Au colloids, which was reported by Sheppard et al and received US approval in 1950 as an antineoplastic and liver imaging agent, few gold-derived monomeric radionuclide complexes have been developed. − 198 Au and 199 Au radionuclides of Au(III) bis-thiosemicarbazones bearing diversified dithiosemicarbazone ligands were synthesized and their radiochemistry characterized . In particular, the radionuclide with (1 Z ,1′ Z )- N ′, N ′′′′-((2 E ,3 E )-pentane-2,3-diylidene)bis( N -ethylcarbamohydrazonothioic acid) ligand, 198 Au-TSC was synthesized with >90% radiochemical yield with good stability in phosphate-buffered saline (PBS) and mouse/human serum stability.…”

Section: Radioactive Au Complexes For Radiotherapy and Biodistributionmentioning

confidence: 99%

Next Generation Gold Drugs and Probes: Chemistry and Biomedical Applications

et al. 2023

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The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of inflammatory arthritis including rheumatoid and juvenile arthritis; however, new gold agents have been slow to enter the clinic. Repurposing of auranofin in different disease indications such as cancer, parasitic, and microbial infections in the clinic has provided impetus for the development of new gold complexes for biomedical applications based on unique mechanistic insights differentiated from auranofin. Various chemical methods for the preparation of physiologically stable gold complexes and associated mechanisms have been explored in biomedicine such as therapeutics or chemical probes. In this Review, we discuss the chemistry of next generation gold drugs, which encompasses oxidation states, geometry, ligands, coordination, and organometallic compounds for infectious diseases, cancer, inflammation, and as tools for chemical biology via gold–protein interactions. We will focus on the development of gold agents in biomedicine within the past decade. The Review provides readers with an accessible overview of the utility, development, and mechanism of action of gold-based small molecules to establish context and basis for the thriving resurgence of gold in medicine.

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“…In addition, the use of dithiols as a surface binding motif leads to a higher stability of the AuNPs [24]. Of particular interest is their therapeutic application [25], especially their ability to be used as radiosensitizers by Auger-Meitner electron emission induced by gamma activation [26][27][28] or by direct neutron activation of natural 197 AuNPs generating [ 198 Au]AuNPs (t 1/2 = 2.69 d, β − max 961 keV, 98.99%; γ 412 keV, 95.62%) [12,[29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Radiosynthesis of Stable 198Au-Nanoparticles by Neutron Activation of αvβ3-Specific AuNPs for Therapy of Tumor Angiogenesis

Davarci,

Wängler,

Eberhardt

et al. 2023

Pharmaceuticals

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This paper reports on the development of stable tumor-specific gold nanoparticles (AuNPs) activated by neutron irradiation as a therapeutic option for the treatment of cancer with high tumor angiogenesis. The AuNPs were designed with different mono- or dithiol-ligands and decorated with different amounts of Arg-Gly-Asp (RGD) peptides as a tumor-targeting vector for αvβ3 integrin, which is overexpressed in tissues with high tumor angiogenesis. The AuNPs were evaluated for avidity in vitro and showed favorable properties with respect to tumor cell accumulation. Furthermore, the therapeutic properties of the [198Au]AuNPs were evaluated in vitro on U87MG cells in terms of cell survival, suggesting that these [198Au]AuNPs are a useful basis for future therapeutic concepts.

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The Distribution of¹⁹⁸Au Injected Intravenously as a Colloid and in Solution

Cited by 6 publications

References 17 publications

Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration

Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration

Next Generation Gold Drugs and Probes: Chemistry and Biomedical Applications

Radiosynthesis of Stable 198Au-Nanoparticles by Neutron Activation of αvβ3-Specific AuNPs for Therapy of Tumor Angiogenesis

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The Distribution of198Au Injected Intravenously as a Colloid and in Solution

Cited by 6 publications

References 17 publications

Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration

Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration

Next Generation Gold Drugs and Probes: Chemistry and Biomedical Applications

Radiosynthesis of Stable 198Au-Nanoparticles by Neutron Activation of αvβ3-Specific AuNPs for Therapy of Tumor Angiogenesis

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The Distribution of¹⁹⁸Au Injected Intravenously as a Colloid and in Solution