The distribution of serum uric acid values in a population unselected as to gout or hyperuricemia

Mikkelsen, William M.; Dodge, Horace J.; Valkenburg, H. A.; Himes, Scott

doi:10.1016/0002-9343(65)90048-3

Cited by 309 publications

(130 citation statements)

References 8 publications

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“…The present study is in agreement with previous reports in that males had a higher mean level than females (Rich et al, 1978;Jensen et al, 1965;Seegmiller et at., 1963;O'Brien et al, 1966;Mikkelsen et al, 1965). In males a positive age effect on plasma uric acid level was revealed, but it was negative in females.…”

Section: Discussionmentioning

confidence: 93%

Plasma and urine uric acid levels: Heritability estimates and correlation with IQ

1980

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SummaryPlasma and urine uric acid levels were measured in 37 pairs of twins aged 11 or 12 years and their parents. Effect of age differed between sexes and between plasma and urine. Assuming linear regression on age, the uric acid levels were adjusted for a fixed age, then standardized with mean 0 and standard deviation 1. The standardized values for plasma yielded a high MZ twin correlation (0.8429), a high mid-parent-offspring regression (0.7516) and a high parent-offspring regression (0.5100). Because of a high husband-wife correlation (0.3771) a model was used for estimating parameters, where effects of assortative mating and/or common within-family environment were incorporated. In plasma two sets of estimates were obtained: VA/Vp=0.7064, 0.3251; VD/Vp=0.1010, 0.1769; and VEC (variance due to common within-family environment)/Vp=0.0362, 0.3416. In urine VA/Vt,=0.4125, Vo/Vp=0.3556 and VEc/Vp=--0.1106. It was concluded that heritability of uric acid level was not less than 0.3 in plasma and not less than 0.4 in urine. The plasma uric acid level and IQ was positively correlated (between 0.17 and 0.34), but not significant.

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Section: Discussionmentioning

confidence: 93%

Plasma and urine uric acid levels: Heritability estimates and correlation with IQ

1980

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“…In females, the SUA levels rose to a minor peak at 15-19 years followed by a decline and levelling at approximately 40 years and reached peak levels at 50-54 years and 60-64 years, due to a decline in the production of estrogen due to menopausal conditions. 6 In 1999, Culleton et al, in the Framingham Heart Study, also reported that there is a gradual increase in SUA levels in females from the fourth to the seventh decades of life. 7 In our study as well, the proportion of HU subjects increased with progression in age; maximum subjects were evident in the age category of >50 years followed by 31-50 years and ≤30 years.…”

Section: Discussionmentioning

confidence: 99%

“…4,5 In the previous literature, SUA levels were reported to increase with advancing age. 6,7 In the US study conducted from 1959 to 1960, the SUA values in males rose rapidly to a peak level at 20-24 years followed by a slight decline and a rise at 55 to 59 years. In females, the SUA levels rose to a minor peak at 15-19 years followed by a decline and levelling at approximately 40 years and reached peak levels at 50-54 years and 60-64 years, due to a decline in the production of estrogen due to menopausal conditions.…”

Section: Discussionmentioning

confidence: 99%

A study of the association between hyperuricemia and knee osteoarthritis in the coastal Indian population

et al. 2018

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INTRODUCTIONHyperuricemia is an abnormally high level of uric acid in the blood. In the pH conditions of body fluid, uric acid exists largely as urate, the ion form. The amount of urate in the body depends on the balance between the amount of purines eaten in food, the amount of urate synthesised within the body (e.g. through cell turnover), and the amount of urate that is excreted in urine or through the gastrointestinal tract. In humans, the upper end of the normal range is 6mg/dL (360µmol/L) for women and 6.8mg/dL (400µmol/L) for men. ABSTRACTBackground: Hyperuricemia and knee osteoarthritis are common problems that affect the aging population and they have an increasing prevalence with obesity and hypertension. Epidemiologic and immunological studies have shown a possible relation between the two conditions. Uric acid is a common factor found in association with the evaluation and treatment of osteoarthritis. There are serious therapeutic implications, particularly in using traditional gout medications, for use in osteoarthritis treatment is to be explored in detail. Our diet contains a good amount of purine containing food stuffs. The common items which increase our uric acid levels are red meat, all alcoholic beverages, seafood and shellfish. Previous studies have shown an association between serum uric acid and generalized osteoarthritis, but with the limited studies on the evidence of association between serum uric acid and knee joint osteoarthritis. This study aims to know the association between serum uric acid levels and osteoarthritis of knee joint. Methods: This is a Cross-sectional analytical study including eight hundred and thirty patients (461 males, 369 females) in a population screening during a patient education program on joint pains. Their serum uric acid level, total count, differential count, erythrocyte sedimentation rate (ESR), height, weight, blood pressure, BMI and standing radiographs of affected knees were obtained. The presence of radiographic osteoarthritis of the knee was analyzed using Kellgren-Lawrence system. The patients were divided into cohorts with hyperuricemia and osteoarthritis and compared with the subjects without either of the problems. Results: Isolated knee joint osteoarthritis is present in 183 subjects (22%), hyperuricemia was present in 154 subjects (18.55%). There is a significant positive association present between isolated knee joint osteoarthritis and the highest level of serum uric acid (adjusted odd's ratio-2.24, 95% confidence interval-1.57-2.94). There is a significant positive association between high serum uric acid levels and progression of the knee joint osteoarthritis (highest level versus lowest level of serum uric acid odd's ratio-1.38, 95% confidence interval-0.96-2.74). Conclusions: It is concluded that knee joint osteoarthritis and its progression are associated with hyperuricemia.

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“…A correlation of hyperuricemia with development of myocardial infarction was found in prospective studies of the members of the Framingliam community in Massachusetts (21), although it. was not confirmed in a similar prospective study of Tecumseh, Michigan (22). An investigation of diseases developing i n hyperuricemic patients at the Kaiser Hospital in San Francisco (23) also failed to confirm this study.…”

Section: Directions and Prospects For Future Research On Gout J Edwimentioning

confidence: 77%

Directions and prospects for future research on gout

Seegmiller

1975

Arthritis & Rheumatism

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The distribution of serum uric acid values in a population unselected as to gout or hyperuricemia

Cited by 309 publications

References 8 publications

Plasma and urine uric acid levels: Heritability estimates and correlation with IQ

Plasma and urine uric acid levels: Heritability estimates and correlation with IQ

A study of the association between hyperuricemia and knee osteoarthritis in the coastal Indian population

Directions and prospects for future research on gout

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