The Distribution of Serum Protein and Enzyme Group Systems among North Indians

Blake, N. M.; Kirk, R. L.; McDermid, E. M.; Omoto, Keiichi; Ahuja, Y. R.

doi:10.1159/000152437

Cited by 53 publications

(36 citation statements)

References 3 publications

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“…Only three phenotypes were present among the Parsis, and the frequencies of the PHs^ and PHsB alleles (0.404 and 0.596, respectively) are comparable to the frequencies of these alleles in some of the caste groups in northern India reported by Blake et al [1972], The PHsQ frequency in the Parsis is lower than that for Gujarati and Marathi-speaking persons in Bombay [Blake et a i, 1970]. Notable is the absence of the PHsc allele in the Parsis, though it is present in the Iranis.…”

Section: Red Cell Acid Phosphatasesupporting

confidence: 53%

The Distribution of some Enzyme Group Systems Among Parsis and Iranis in Bombay

Undevia¹,

Blake²,

Kirk³

et al. 1972

Hum Hered

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A total of 418 Parsis and 48 Zoroastrian Iranis were sampled in Bombay and tested for 9 red cell enzyme systems controlled by genes at 11 loci. There were marked differences between Parsis and Iranis for the frequency of alleles in the acid phosphatase system, but the two populations were similar in the frequency of alleles in the phosphoglucomutase and adenylate kinase systems. No electrophoretic variation was found in either population for the peptidase A and B, ‘oxidase’, malate dehydrogenase and phosphoglucomutase (locus 2) systems, or for the lactate dehydrogenase and 6-phosphogluconate dehydrogenase systems among the small series of Iranis. Among the Parsis, however, for the 6PGD system the PGD^C allele had a frequency of 0.0263 and the PGD^R allele had a frequency of 0.0012. The Parsis also had a relatively high frequency of LDH ‘Calcutta’ variants, the frequency of the LDH^Cal-1 allele being 0.0179. The results are discussed in relation to the history of the Parsi and Irani populations in India, and compared with previous studies among Marathi and Gujarati-speaking populations in Bombay and other groups elsewhere in India.

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Section: Red Cell Acid Phosphatasesupporting

confidence: 53%

The Distribution of some Enzyme Group Systems Among Parsis and Iranis in Bombay

Undevia¹,

Blake²,

Kirk³

et al. 1972

Hum Hered

Self Cite

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“…Three phenotypes were observed, and the ADA^ and ADA^ frequencies were 0-87 and 0-13 respectively. The value for ADA^ is twice that found among northern Europeans (Spencer, Hopkinson and Harris, 1968) and comparable with the very high values found reeently among north Indians by Blake et al (1972). Further population data for the Middle East are required to determine the significance of the present findings.…”

Section: Red Cell Enzyme Groupssupporting

confidence: 78%

“…In the present study four examples of the PHI 3-1 combination were detected, all the other persons being PHI 1-1. Detter et al (1968) first described PHI 3-1 phenotypes among Indians living in England, and Blake et al (1972) have also found just over 1% PHI 3-1 persons in a large series from north India. The finding of a similar frequency among Lebanese in the present study suggests that the PHP allele is widely distributed in the Middle East.…”

Section: Red Cell Enzyme Groupsmentioning

confidence: 98%

The Distribution of Blood, Serum Protein and Enzyme Groups in a Series of Lebanese in Australia

Blake¹,

Rl²,

McDermid³

et al. 1973

Aust J Exp Biol Med

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Summary Blood samples from a series of persons of Lebanese origin living in Sydney have been tested for 9 blood group, 5 serum protein and 16 red cell enzyme systems as well as haemoglobin types. The Lutheran, Kidd and Colton blood group systems and all the serum protein and enzyme group systems reported on here, except haptoglobin and glucose‐6‐phosphate dehydrogenase, have not been studied previously in Lebanese. There were no cases of glucose‐6‐phosphate dehydrogenase deficiency or abnormal haemoglobins nor were any unusual phenotypes detected in the other 29 systems investigated. In the blood group systems there was a relatively high A1/A2 ratio and low frequencies for the Rh ‐ve and Co(b+) phenotypes, but frequencies in the other systems were comparable with values found in studies of other Middle East or European populations. In the Kell system the possibility exists that the Lebanese may have an appreciable frequency of (K‐k‐). Gene frequencies for die serum protein systems were similar to other Middle East populations where comparable figures are available, and the same is true for the red cell enzyme systems. For glucose‐6‐phosphate dehydrogenase and phosphohexose isomerase, values obtained suggest that frequencies in north India are similar to those in Lebanon. The overall results are discussed in relation to selection in a migrant population.

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“…PGI 5-1 was originally described as a Furopean variant but its occurrence in India was described initially in north India by Blake et al (1971) and later in west- ern India. Till today 17 PGI 5-1 variants have been reported in the Indian populations.…”

Section: C) the P G I ~ Allelementioning

confidence: 99%

Population genetic study of red cell enzyme phosphoglucose isomerase in India

Papiha

Chahal

1984

Jap J Human Genet

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SummaryThe distribution of red cell enzyme phosphoglucose isomerase was studied by starch gel electrophoresis in 27 different endogamous groups of India. Forty one electrophoretic variants belonging to four out of the nine known heterozygote types and one rare homozygous variant (PGI-3) were found. Comparison of the results with in India and certain other populations showed that PGI is certainly another useful genetic parameter for the study of population diversity in Asia.Inherited variation of the enzyme phosphoglucose isomerase [PGI; o~-D-glucose 6-phosphate ketol isomerase; EC 5.3.1.9] was initially described by Detter et al. (1968), the enzyme being referred to as phosphohexose isomerase. Since this discovery there have been reports of rare genetically determined variants or variants with low catalytic activities from various populations of the world Fitch et al., 1968;Paglia et al., 1969;Shinoda, 1970; Tariverdian et aI., 1970;Welch 1971;Luan Eng and Welch, 1972;Sanpitak et aL, 1973; Nakashima et aI., 1973;Isacchi et al., 1979), most of which concerns the sporadic occurrence of one or two of the nine heterozygotic types originally described in addition to the usual homozygous phenotype PGI-1. The exceptions are the heterozygous phenotypes PGI 3-1 and 4-1 which are of particular interest in Asiatic populations. In both the studies from London (Detter et al., 1968;Welch, 1971) the Asiatic Indians showed an appreciable frequency of the variant PGI 3-1 and subsequent studies of indigenous samples confirmed that the PGI a allele attains polymorphic frequencies in certain populations of India. Indeed, the relatively high frequency of this allele led to the detection of the homozygous phenotype PGI-3 (Papiha et aL, 1974). Ishimoto and Kuwata (1974) compiled the PGI studies in Japan and showed that in Japanese PGI 4-1 variant is more frequent than the other known heterozygous variants. This relatively high frequency of the PGI 4 allele in Japan consistent with the previous studies of Shinoda (1970), also led to the finding of a rare

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The Distribution of Serum Protein and Enzyme Group Systems among North Indians

Cited by 53 publications

References 3 publications

The Distribution of some Enzyme Group Systems Among Parsis and Iranis in Bombay

The Distribution of some Enzyme Group Systems Among Parsis and Iranis in Bombay

The Distribution of Blood, Serum Protein and Enzyme Groups in a Series of Lebanese in Australia

Population genetic study of red cell enzyme phosphoglucose isomerase in India

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