The Distribution of Red Cells and Plasma in Large and Minute Vessels of the Normal Dog, Determined by Radioactive Isotopes of Iron and Iodine 1

Blood Volume Alterations in Congestive Heart Failure

“…Fiftyseven studies were made on 26 was not present in the subjects reported here. Therefore, the weights after restoration of compensation were taken as closest to the "normal" weights of the cardiac subjects and used as reference for all determinations in these cases.…”

“…In four of the subjects (Nos. 11,17,25,26) there was an increase in total blood volume following therapy of heart failure. However, in one of these (No.…”

“…To conclude from this alone that the former must be distributed extravascularly is to imply that the relative cell volume is the same throughout the body. However, splenic blood, which is rapidly exchangeable with injected Fetagged erythrocytes, has a much higher hematocrit value than blood in the large vessels (26). In subjects with markedly enlarged spleens, the ratio, total body relative cell volume venous hematocrit value is frequently over 1.00 (27), a circumstance which is very rarely observed in other subjects.…”

Polycythemia vera: myths, mechanisms, and management

“…122 Unfortunately, the hematocrit level, whether directly determined by centrifugation or calculated from the mean corpuscular volume (MCV) and the red cell count, will not reflect these changes because even under normal circumstances, the distribution of red cells and plasma is not uniform throughout the circulatory system. [123][124][125] Rather, as demonstrated by independent determinations of the red cell mass and plasma volume, the ratio of red cells to plasma is higher in the peripheral vessels, venous or arterial, than it is in the body as a whole (ie, whole body hematocrit derived from independent measurements of red cell mass and plasma volume/peripheral venous hematocrit ϭ 0.92). 126,127 This is a consequence of both the slower flow of the peripherally displaced plasma compared with the axial red cells and plasma skimming in the smaller vessels.…”

Erythrocyte, plasma and total blood volumes of pigs from birth through six weeks of age

“…The fact that the basic concepts published by Gregersen were correct and that the dilution volume of T-1824 does represent the true plasma volume has been veri fied by many subsequent studies. Simultaneous determina tions of the volume distributions of T-1824 and the anti gens, bovine albumin, bovine globulin and the polysaccharide SIII (Gregersen et al, 1945;Gregersen et al, 1950) as well as similar tests with T-1824 and albumin I^^ (Franks and Zizza, 1958;Gibson et al, 1946) and hemoglobin (Allenet al, 1953a) all yield essentially the same value for plasma volumes, providing the latter is calculated from extrapolation of the time-concentration curve on a semi log plot. Allen (1953) devised a simple paper pulp extraction technic for removing T-1824 dye from serum.…”