The distribution of progestin receptor mRNA in rat brainstem

Curran-Rauhut, Meredith; Petersen, Sandra L.

doi:10.1016/s1567-133x(02)00011-x

Cited by 41 publications

(34 citation statements)

References 22 publications

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“…This up-regulation has been previously demonstrated by our group in the hypothalamus and the cerebral cortex of the rabbit by using RT-PCR [12]. In several brain regions of other species the up-regulation of PR mRNA expression by estradiol using in situ hybridization has also been observed [20][21][22]. It has been reported that the effects of estradiol on PR expression are exerted at transcriptional level mediated by estrogen-responsive elements located in the PR promoter [10,23].…”

Section: Discussionsupporting

confidence: 65%

Progesterone receptor mRNA expression and distribution in the female rabbit brain

Mendoza-Rodríguez

Mendoza-Garcés

Vanoye-Carlo

et al. 2007

The Journal of Steroid Biochemistry and Molecular Biology

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Section: Discussionsupporting

confidence: 65%

Progesterone receptor mRNA expression and distribution in the female rabbit brain

Mendoza-Rodríguez

Mendoza-Garcés

Vanoye-Carlo

et al. 2007

The Journal of Steroid Biochemistry and Molecular Biology

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“…In addition, PROG also binds to membrane PROG receptor (mPR)-α and -β [30]. PR-A, PR-B, and mPR-α are expressed in the striatum [31,32], while PR-A, PR-B, and mPR-β have been found in the substantia nigra [33,34,35]. Whereas the mechanisms of PROG action in the striatum have received little attention, PROG is reported to mediate its effect through multiple mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effect of Progesterone in MPTP-Treated Male Mice

et al. 2015

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Background: Numerous studies have reported on the neuroprotective activity of estradiol, whereas the effect of the other ovarian steroid, progesterone, is much less documented. Methods: This study sought to investigate neuroprotection with a low dose of progesterone (1 µg) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated male mice to model Parkinson's disease and compare it to the effect of this steroid in intact mice (experiment 1). We also investigated if high doses of progesterone could protect dopaminergic neurons already exposed to MPTP (experiment 2). We measured progesterone effects on various dopaminergic markers [dopamine and its metabolites, dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2)] and on neuroactive steroids in both plasma and the brain. Results: For experiment 1, our results showed that progesterone completely prevented the effect of MPTP toxicity on dopamine concentrations, on the increase in the 3-methoxytyramine/dopamine ratio, as well as on VMAT2-specific binding in the striatum and the substantia nigra. Progesterone decreased MPTP effects on 3,4-dihydroxyphenylacetic acid concentrations and DAT-specific binding in the lateral part of the anterior striatum and in the middle striatum (medial and lateral parts). Progesterone treatment of intact mice had no effect on the markers investigated. For experiment 2, measures of dopaminergic markers in the striatum showed that 8 mg/kg of progesterone was the most effective dose to reduce MPTP effects, and more limited effects were observed with 16 mg/kg. We found that progesterone treatment increases the levels of brain progesterone itself as well as of its metabolites. Conclusion: Our result showed that progesterone has neuroprotective effects on dopaminergic neurons in MPTP-treated male mice.

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“…43). Centrally, the ER and progesterone receptor (PR) have been found within the rat brain stem (11,12,23,35,39,52,63), but little work has been done to localize the ER and PR throughout the central vestibular relays of the brain stem network (12). No electrophysiological or c-Fos studies have been conducted to determine whether there are sex differences in the cellular response to vestibular stimuli.…”

Section: Discussionmentioning

confidence: 99%

Sex and estrous cycle differences in the behavioral effects of high-strength static magnetic fields: role of ovarian steroids

Cason¹,

DenBleyker²,

Ferrence³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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Advances in magnetic resonance imaging are driving the development of higher-resolution machines equipped with high-strength static magnetic fields (MFs). The behavioral effects of high-strength MFs are largely uncharacterized, although in male rats, exposure to 7 T or above induces locomotor circling and leads to a conditioned taste avoidance (CTA) if paired with a novel taste. Here, the effects of MFs on male and female rats were compared to determine whether there are sex differences in behavioral responses and whether these can be explained by ovarian steroid status. Rats were given 10-min access to a novel saccharin solution and then restrained within a 14-T magnet for 30 min. Locomotor activity after exposure was scored for circling and rearing. CTA extinction was measured with two-bottle preference tests. In experiment 1, males were compared with females across the estrous cycle after a single MF exposure. Females circled more and acquired a more persistent CTA than males; circling was highest on the day of estrus. In experiment 2, the effects of three MF exposures were compared among intact rats, ovariectomized females, and ovariectomized females with steroid replacement. Compared with intact rats, ovariectomy increased circling; estrogen replacement blocked the increase. Males acquired a stronger initial CTA but extinguished faster than intact or ovariectomized females. Thus the locomotor circling induced by MF exposure was increased in females and modulated by ovarian steroids across the estrous cycle and by hormone replacement. Furthermore, female rats acquired a more persistent CTA than male rats, which was not dependent on estrous phase or endogenous ovarian steroids.

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The distribution of progestin receptor mRNA in rat brainstem

Cited by 41 publications

References 22 publications

Progesterone receptor mRNA expression and distribution in the female rabbit brain

Progesterone receptor mRNA expression and distribution in the female rabbit brain

Neuroprotective Effect of Progesterone in MPTP-Treated Male Mice

Sex and estrous cycle differences in the behavioral effects of high-strength static magnetic fields: role of ovarian steroids

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