The Distribution of Noradrenergic Nerves in the Human Lower Urinary Tract

Gosling, J. A.; Dixon, J. S.; Jen, Phillip Y.P.

doi:10.1159/000052314

Cited by 57 publications

(54 citation statements)

References 33 publications

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“…The body of the bladder receives a relatively sparse innervation by noradrenergic nerves. The density of noradrenergic nerves increases markedly toward the bladder neck, where the smooth muscle receives a dense noradrenergic nerve supply, particularly in the male (Gosling et al, 1999). Noradrenergic nerves also occur in the lamina propria of the bladder, only some of which are related to the vascular supply.…”

Section: Peripheral Targetsmentioning

confidence: 99%

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Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence

Andersson

Wein²

2004

Pharmacol Rev

453

364

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Section: Peripheral Targetsmentioning

confidence: 99%

“…Noradrenergic nerves also occur in the lamina propria of the bladder, only some of which are related to the vascular supply. Their functional significance remains to be established (Gosling et al, 1999).…”

Section: Peripheral Targetsmentioning

confidence: 99%

Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence

Andersson

Wein²

2004

Pharmacol Rev

453

364

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“…Intramural ganglia are surrounded by a capsule and lie along nerve trunks being interconnected to form a plexus. They can occur in every region of the bladder but are more common in the trigone region where the ureters enter the organ (Gosling 1986, Gabella 1990). The trigone is a small region of the dorsal wall of the bladder located in the vicinity of the bladder cervix which has a different embryological origin from the detrusor muscle and represents an extension of the longitudinal muscle of the ureters (De Groat and Booth 1984).…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical characteristics and distribution of neurons in the intramural ganglia supplying the urinary bladder in the male pig

Pidsudko

2013

Polish Journal of Veterinary Sciences

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This study investigated the distribution and chemical coding of neurons in intramural ganglia of the urinary bladder trigone (UBT-IG) and cervix (UBC-IG) in the male pig using combined retrograde tracing and double-labelling immunohistochemistry. Additionally, immunoblotting was used to confirm the presence of marker enzymes for main populations of autonomic neurons. Retrograde fluorescent tracer Fast Blue (FB) was injected into the wall of both the left and right side of the bladder trigone, cervix and apex during laparotomy performed under thiopental anaesthesia. Twelve μm-thick cryostat sections were processed for double-labelling immunofluorescence with antibodies against tyrosine hydroxylase (TH), dopamine β-hydroxylase (DBH), neuropeptide Y (NPY), somatostatin (SOM), galanin (GAL), vasoactive intestinal polypeptide (VIP), nitric oxide synthase (NOS), calcitonin gene-related peptide (CGRP), substance P (SP) and vesicular acetylcholine transporter (VAChT). UBT-IG and UBC-IG neurons in both parts of the organ formed characteristic clusters (from few to tens of neuronal cells) found under visceral peritoneum or in the outer muscular layer. Immunohistochemistry revealed several subpopulations in UBT-IG and UBC-IG neurons, namely noradrenergic (ca. 76% and 76%), cholinergic (ca. 22% and 20%), non-adrenergic/non-cholinergic nerve cells (ca. 1.5% and 3.8%), NPY-(ca. 66% and 58%), SOM-(ca. 39% and 39 %), VIP-(ca. 5% and 0%) and NOS-immunoreactive (IR) (ca. 1.5% and 3.8%), respectively. Immunoblotting using antibodies to TH and VAChT showed the presence of studied proteins as revealed by the presence of protein bands of the correct molecular weight. This study has revealed a relatively large population of differently coded UBT-and UBC-IG neurons, which constitute an important element of the complex neuroendocrine system involved in the regulation of the male urogenital organs function.

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“…Buna paralel olarak nonselektif alfa-1 reseptör blokörleri ile yapılan çalışmalar sonunda istirahat halindeki üretra basıncının düşürül-düğü gözlenmiştir (7,8). Prostat dokusunda hem alfa-1 reseptörleri hemde alfa-2 reseptörleri bulunmasına karşın düz kasların kasılmasında alfa-1 reseptörlerin sorumlu olduğu, alfa-2 reseptörle-rin ise özellikle noradrenalin salgılamasını kontrol eden feed-back mekanizmasında rol oynadığı bilinmektedir (9,10,11,12). Nonselektif alfa-1 reseptör blokörlerin kullanımı ile bu mekanizma ortadan kalkmakta, ortostatik hipotansiyon ve taşikardi gibi istenmeyen yan etkiler oluşabilmekte-dir.…”

Section: Discussionunclassified

Beni̇gn Prostat Hi̇perplazi̇si̇ni̇n Semptomati̇k Tedavi̇si̇nde Doksazosi̇ni̇n Etki̇nli̇ği̇

Ahmet;İMAMOĞLU¹

2001

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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The Distribution of Noradrenergic Nerves in the Human Lower Urinary Tract

Cited by 57 publications

References 33 publications

Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence

Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence

Immunohistochemical characteristics and distribution of neurons in the intramural ganglia supplying the urinary bladder in the male pig

Beni̇gn Prostat Hi̇perplazi̇si̇ni̇n Semptomati̇k Tedavi̇si̇nde Doksazosi̇ni̇n Etki̇nli̇ği̇

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