“…Noradrenergic fibers were described as highly ramified and localized in a sunburst orientation within the center of each barrel. Such organization is supported by other studies, which have shown selective connectivity between the rodent locus coeruleus (LC) and its efferent target sites (Mason and Fibiger, 1979;Cedarbaum and Saper, 1981;Waterhouse et al, 1983;Loughlin et al, 1986aLoughlin et al, , 1986bMorrison and Foote, 1986;Simpson et al, 1997). In general, these findings contradict other early investigations, which emphasized the diffuse projection pattern and global actions of the LC/norepinephrine (NE) system (Anden et al, 1966;Ungerstedt, 1971;Pickel et al, 1974;Nakamura and Iwama, 1975;AstonJones andBloom, 1981a, 1981b;Aston-Jones et al, 1986).…”