The distribution of MICA alleles in an Austrian population: Evidence for increasing polymorphism

Wenda, S.; Faé, Ingrid; Sanchez‐Mazas, Alicia; Nunes, José Manuel; Mayr, Wolfgang R.; Fischer, Gottfried

doi:10.1016/j.humimm.2013.06.013

Cited by 9 publications

(11 citation statements)

References 35 publications

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“…In addition, the clinical relevance of matching for MICA in the context of HLA-matched HCT donor-recipient pairs has been questioned based on the putative strong LD between MICA and HLA-B [5] reported in different populations [18–20]. Although the global LD between the 2 loci is significant, it was reported that a limited number of HLA-B alleles showed significant LD with a specific MICA allele [19]. In the present study, some of the estimated MICA~HLA-B haplotypes showed significant LD (>D′ = .4), but these haplotypes represented approximately 45% of the total haplotype frequency in the analyzed cohort.…”

Section: Discussionmentioning

confidence: 99%

MHC Class I Chain-Related Gene A (MICA) Donor-Recipient Mismatches and MICA-129 Polymorphism in Unrelated Donor Hematopoietic Cell Transplantations Has No Impact on Outcomes in Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, or Myelodysplastic Syndrome: A Center for International Blood and Marrow Transplant Research Study

Askar

Sobecks

Wang³

et al. 2017

Biology of Blood and Marrow Transplantation

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Single-center studies have previously reported associations of MHC Class I Chain-Related Gene A (MICA) polymorphisms and donor-recipient MICA mismatching with graft-versus-host disease (GVHD) after unrelated donor hematopoietic cell transplantation (HCT). In this study, we investigated the association of MICA polymorphism (MICA-129, MM versus MV versus VV) and MICA mismatches after HCT with 10/10 HLA–matched (n = 552) or 9/10 (n = 161) unrelated donors. Included were adult patients with a first unrelated bone marrow or peripheral blood HCT for acute lymphoblastic leukemia, acute myeloid leukemia, or myelodysplastic syndrome that were reported to the Center for International Blood and Marrow Transplant Research between 1999 and 2011. Our results showed that neither MICA mismatch nor MICA-129 polymorphism were associated with any transplantation outcome (P < .01), with the exception of a higher relapse in recipients of MICA-mismatched HLA 10/10 donors (hazard ratio [HR], 1.7; P = .003). There was a suggestion of association between MICA mismatches and a higher risk of acute GVHD grades II to IV (HR, 1.4; P = .013) There were no significant interactions between MICA mismatches and HLA matching (9/10 versus 10/10). In conclusion, the findings in this cohort did not confirm prior studies reporting that MICA polymorphism and MICA mismatches were associated with HCT outcomes.

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Section: Discussionmentioning

confidence: 99%

MHC Class I Chain-Related Gene A (MICA) Donor-Recipient Mismatches and MICA-129 Polymorphism in Unrelated Donor Hematopoietic Cell Transplantations Has No Impact on Outcomes in Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, or Myelodysplastic Syndrome: A Center for International Blood and Marrow Transplant Research Study

Askar

Sobecks

Wang³

et al. 2017

Biology of Blood and Marrow Transplantation

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“…Similar to what has been hypothesized for HLA genes , this restricted polymorphism may be due to a genetic bottleneck created by disease outbreak and/or population settlement/migration. MICA*001 , MICA*020 , MICA*045 , and MICA*052 are specific to Europeans , South American Indians , Chinese , and Thais , respectively. The fact that these alleles are abundant just in a specific region of the planet indicates that certain alleles may give rise to more specialized proteins in a given localized microbial environment (although migratory influences could also play a role).…”

Section: Polymorphism Of Mica and Micbmentioning

confidence: 99%

“…The following populations were included for frequency calculations. MICA : Thailand: Northeastern Thais ; Japan ; China: Li nationality of Southern China , Zhuang nationality of Southern China , Southern Han population , Han population , Northern Han population ; Africa: North Morocco ; Nigerian ; Europe: Southeastern Spain , France , Slovakia , Austria ; South America: Southwest Brazil Amerindians , European Brazilians, Euro‐Brazilian from Parana State, Southeast of Brazil , Sao Paolo , South American Indians ; North America: North American Caucasians , African Americans . MICB : China: Southern Chinese Han , Northern Chinese Han , Zhejiang Han ; Europe: Spain and Wales ; Korea .…”

Section: Polymorphism Of Mica and Micbmentioning

confidence: 99%

Genetics, genomics, and evolutionary biology of NKG2D ligands

Carapito

Bahram

2015

Immunological Reviews

102

108

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Human and mouse NKG2D ligands (NKG2DLs) are absent or only poorly expressed by most normal cells but are upregulated by cell stress, hence, alerting the immune system in case of malignancy or infection. Although these ligands are numerous and highly variable (at genetic, genomic, structural, and biochemical levels), they all belong to the major histocompatibility complex class I gene superfamily and bind to a single, invariant, receptor: NKG2D. NKG2D (CD314) is an activating receptor expressed on NK cells and subsets of T cells that have a key role in the recognition and lysis of infected and tumor cells. Here, we review the molecular diversity of NKG2DLs, discuss the increasing appreciation of their roles in a variety of medical conditions, and propose several explanations for the evolutionary force(s) that seem to drive the multiplicity and diversity of NKG2DLs while maintaining their interaction with a single invariant receptor.

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“…The homopolymer polymorphism located at the end of intron 4 (seven/eight thymidine sequence) [9] for this novel allele was of eight thymidine nucleotides (as for MICA ⁄ 002:01 and MICA ⁄ 029).…”

Section: Resultsmentioning

confidence: 93%

MICA∗078: A novel allele identified in a Moroccan individual affected by celiac disease

et al. 2015

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The distribution of MICA alleles in an Austrian population: Evidence for increasing polymorphism

Cited by 9 publications

References 35 publications

Genetics, genomics, and evolutionary biology of NKG2D ligands

MICA∗078: A novel allele identified in a Moroccan individual affected by celiac disease

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