The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings

Li, Xinnan; Abiko, Kagari; Sheriff, Sulaiman; Maudsley, Andrew A.; Urushibata, Yuta; Ahn, Sinyeob; Tha, Khin Khin

doi:10.3390/metabo12060543

Cited by 5 publications

(7 citation statements)

References 57 publications

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“…WB-MRSI was processed using Metabolic Imaging and Data Analysis System (MIDAS) software version 2.35 (University of Miami, Miami, FL, USA) running on IDL version 8.4.1 (Exelis Visual Information Solutions, Boulder, CO, USA) [ 30 ]. The same procedures were applied to all participants (i.e., TBI patients and control subjects [ 26 ]). The workflow and processing steps are summarized in Figure 1 .…”

Section: Methodsmentioning

confidence: 99%

“…The relationship between the MRI measure (i.e., mode of brain temperature or metabolite ratios) and cognitive function test scores was evaluated using partial correlation analysis in the TBI group. Our previous study on the normal database showed a variation in brain metabolite concentration with aging [ 26 ]. In addition, a considerable variation in the time lapsed from trauma was observed in the patients.…”

Section: Methodsmentioning

confidence: 99%

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Brain Temperature as an Indicator of Cognitive Function in Traumatic Brain Injury Patients

Kitagawa,

Abiko,

Sheriff

et al. 2023

Metabolites

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Whether brain temperature noninvasively extracted by magnetic resonance imaging has a role in identifying brain changes in the later phases of mild to moderate traumatic brain injury (TBI) is not known. This prospective study aimed to evaluate if TBI patients in subacute and chronic phases had altered brain temperature measured by whole-brain magnetic resonance spectroscopic imaging (WB-MRSI) and if the measurable brain temperature had any relationship with cognitive function scores. WB-MRSI was performed on eight TBI patients and fifteen age- and sex-matched control subjects. Brain temperature (T) was extracted from the brain’s major metabolites and compared between the two groups. The T of the patients was tested for correlation with cognitive function test scores. The results showed significantly lower brain temperature in the TBI patients (p < 0.05). Brain temperature derived from N-acetylaspartate (TNAA) strongly correlated with the 2 s paced auditory serial addition test (PASAT-2s) score (p < 0.05). The observation of lower brain temperature in TBI patients may be due to decreased metabolic activity resulting from glucose and oxygen depletion. The correlation of brain temperature with PASAT-2s may imply that noninvasive brain temperature may become a noninvasive index reflecting cognitive performance.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Brain Temperature as an Indicator of Cognitive Function in Traumatic Brain Injury Patients

Kitagawa,

Abiko,

Sheriff

et al. 2023

Metabolites

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“…To avoid further confounding effects, the three study groups were also similar with respect to age and PTA values (although we failed to exclude hearing loss cases completely). Both these factors have been found to in uence metabolite levels in CNS 78, [113][114][115][116] . We were also the rst ones in human MRS research, to divide the groups based on tinnitus status and laterality.…”

Section: Tinnitus Heterogeneity and Participants' Inclusionmentioning

confidence: 99%

Is it up there? - an MR spectroscopy study of frontal lobes and non-primary-auditory temporal areas in subjective bilateral and unilateral tinnitus

Wójcik

Kochański

Cieśla

et al. 2023

Preprint

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Subjective tinnitus is a prevalent, though heterogeneous, condition whose pathophysiological mechanisms are still under investigation. Based on animal models, changes in neurotransmission along the auditory pathway have been suggested as co-occurring with tinnitus. It has not, however, been studied whether such effects can also be found in other sites beyond the auditory cortex. Our MR spectroscopy study is the first one to measure composite levels of glutamate and glutamine (Glx; and other central nervous system metabolites) in bilateral medial frontal and non-primary auditory temporal brain areas in tinnitus. We studied two groups of participants with unilateral and bilateral tinnitus and a control group without tinnitus, all three with a similar hearing profile. We found no metabolite level changes as related to tinnitus status in neither region of interest, except for a tendency of an increased concentration of Glx in the left frontal lobe in people with bilateral vs unilateral tinnitus. Slightly elevated depressive and anxiety symptoms are also shown in participants with tinnitus, as compared to healthy individuals, with the bilateral tinnitus group marginally more affected by the condition. We discuss the null effect in the temporal lobes, as well as the role of frontal brain areas in chronic tinnitus, with respect to hearing loss, attention mechanisms and psychological well-being. We furthermore elaborate on the design-related and technical obstacles when using MR spectroscopy to elucidate the role of neurometabolites in tinnitus.

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“…N-acetylaspartate (NAA) is used in magnetic resonance spectroscopy as a biomarker of neuronal health, integrity, and viability [ 14 ]. Using ratios between these metabolites instead of their absolute concentrations is more common in routine clinical practice due to their simpler acquisition and processing [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

A Comparison of 7 Tesla MR Spectroscopic Imaging and 3 Tesla MR Fingerprinting for Tumor Localization in Glioma Patients

Lazen,

Lima Cardoso,

Sharma

et al. 2024

Cancers

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This paper investigated the correlation between magnetic resonance spectroscopic imaging (MRSI) and magnetic resonance fingerprinting (MRF) in glioma patients by comparing neuro-oncological markers obtained from MRSI to T1/T2 maps from MRF. Data from 12 consenting patients with gliomas were analyzed by defining hotspots for T1, T2, and various metabolic ratios, and comparing them using Sørensen–Dice similarity coefficients (DSCs) and the distances between their centers of intensity (COIDs). The median DSCs between MRF and the tumor segmentation were 0.73 (T1) and 0.79 (T2). The DSCs between MRSI and MRF were the highest for Gln/tNAA (T1: 0.75, T2: 0.80, tumor: 0.78), followed by Gly/tNAA (T1: 0.57, T2: 0.62, tumor: 0.54) and tCho/tNAA (T1: 0.61, T2: 0.58, tumor: 0.45). The median values in the tumor hotspot were T1 = 1724 ms, T2 = 86 ms, Gln/tNAA = 0.61, Gly/tNAA = 0.28, Ins/tNAA = 1.15, and tCho/tNAA = 0.48, and, in the peritumoral region, were T1 = 1756 ms, T2 = 102 ms, Gln/tNAA = 0.38, Gly/tNAA = 0.20, Ins/tNAA = 1.06, and tCho/tNAA = 0.38, and, in the NAWM, were T1 = 950 ms, T2 = 43 ms, Gln/tNAA = 0.16, Gly/tNAA = 0.07, Ins/tNAA = 0.54, and tCho/tNAA = 0.20. The results of this study constitute the first comparison of 7T MRSI and 3T MRF, showing a good correspondence between these methods.

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The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings

Cited by 5 publications

References 57 publications

Brain Temperature as an Indicator of Cognitive Function in Traumatic Brain Injury Patients

Brain Temperature as an Indicator of Cognitive Function in Traumatic Brain Injury Patients

Is it up there? - an MR spectroscopy study of frontal lobes and non-primary-auditory temporal areas in subjective bilateral and unilateral tinnitus

A Comparison of 7 Tesla MR Spectroscopic Imaging and 3 Tesla MR Fingerprinting for Tumor Localization in Glioma Patients

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