The distribution of immunoreactive chromogranins, S-100 protein, and vasoactive intestinal peptide in compound tumors of the adrenal medulla

Tischler, Arthur S.; Dayal, Yogeshwar; Balogh, Károly; Cohen, Richard B.; Connolly, Jennifer; Tallberg, Kirsten

doi:10.1016/s0046-8177(87)80268-x

Cited by 33 publications

(9 citation statements)

References 20 publications

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“…Tumor cells in pheochromocytomas retain their ability to express neuronal and neuroendocrine proteins including neurofilament protein (Osborn et al, 1982;Lehto et al, 1983;Miettinen et al, 1985Miettinen et al, , 1987Trojanowski and Lee, 1985), chromogranin A (Lloyd et al, 1985(Lloyd et al, , 1986Tischler et al, 1987;Hacker et al, 1988;Fraga et al, 1993), synaptophysin (Gould et al, 1987;Miettinen, 1987;Fraga et al, 1993), ␥-enolase (neuronspecific enolase) (Tapia et al, 1981;Hacker et al, 1988;Fraga et al, 1993), PGP9.5 (Rode et al, 1985), catecholamines and their synthesizing enzymes (Lloyd et al, 1986), and multiple neuropeptides (Mendelsohn et al, 1982;DeLellis et al, 1983;Lloyd et al, 1984;Lundberg et al, 1986;Tischler et al, 1987;Hacker et al, 1988;Sano et al, 1991;Polak, 1993). Several in vitro studies using the PC12 rat pheochromocytoma cell line have demonstrated the presence of neuronal cytoskeletal proteins (reviewed in Katsetos et al, 1998B), including neurofilament protein (Virtanen et al, 1981;Lee et al, 1982), microtubule-associated proteins (MAPs) (reviewed in Katsetos et al, 1998B), and the neuronspecific class III ␤-tubulin isotype (Asai and Remolona, 1989;Katsetos et al, 1998B), ascertaining its neuronal consanguinity.…”

Section: Introductionmentioning

confidence: 99%

Class III β‐Tubulin isotype (β III) in the adrenal medulla: II. Localization in primary human pheochromocytomas

et al. 1998

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The distribution of beta III in human pheochromocytomas of the adrenal gland is differentiation-dependent, closely recapitulating chromaffin cell and neuronal phenotypes of the normal adrenal medulla. Our findings indicate that beta III may be used as one of the adjuvant neural markers in the differential diagnosis of adrenal tumors, i.e., pheochromocytoma versus adrenocortical carcinoma. The occurrence of rare beta III-positive cells in cortical carcinomas is exceptional and probably represents the acquisition of a divergent neuroendocrine phenotype. The significance of the latter is unclear, although it may constitute a marker for malignancy.

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Section: Introductionmentioning

confidence: 99%

Class III β‐Tubulin isotype (β III) in the adrenal medulla: II. Localization in primary human pheochromocytomas

et al. 1998

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“…Before surgery, our patient and the four previously reported patients (2, 4, 5) with compound tumors exhibited similar signs and symptomsof an ordinary pheochromocytoma,suggesting that it is difficult to recognize compoundtumors. However, abnormally high concentrations of dopamine and/or its metabolite homovanillic acid were found in all but two cases (3,4). In these two cases, the hormonelevels were not reported (Table 1).…”

Section: Discussionmentioning

confidence: 93%

“…Only six patients with a compoundtumor containing pheochromocytoma and ganglioneuroblastoma have been reported (1)(2)(3)(4)(5) (Table 1). Of these, there were two in-hospital deaths due to metastases from the malignant pheochromocytoma component (1,2).…”

Section: Introductionmentioning

confidence: 99%

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Results of Surgery for a Compound Adrenal Tomor Consisting of Pheochromocytoma and Ganglioneuroblastoma in an Adult. 5-year Follow-up.

et al. 2000

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A rare, compoundadrenal tumor consisting of ganglioneuroblastoma and pheochromocytomawas completely resected in an adult woman.Mostof the tumor was occupied by the ganglioneuroblastoma component. This ganglioneuroblastoma was an intermixed tumor, which is known to have a favorable prognosis in children. Based on the lack of spread, the resectability of the tumor, and the histology of the ganglioneuroblastoma, no adjuvant therapy was employed.Therewas no evidence of recurrence at the 5-year follow-up. This suggests that adjuvant therapy may not be necessary in these compoundtumors.

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“…The specificity of this antibody was reported previously (16). To identify Schwann cells, serial sections were stained with S100 protein (S100p) antibody (1:1000, DAKO), which is an antibody known to detect Schwann cells (17,18). For control study, normal rabbit serum was applied instead of the antibody of neurofibromin or S100p.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Neurofibromin and NF1 Gene Analysis in Composite Pheochromocytoma and Tumors Associated with von Recklinghausen's Disease

Kimura

Watanabe

Fukase³

et al. 2002

Modern Pathology

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Composite tumor of pheochromocytoma and neuroblastoma, or ganglioneuroma, or ganglioneuroblastoma (composite pheochromocytoma), also known as mixed neuroendocrine and neural tumor, are sometimes combined with neurofibromatosis type 1 (NF1). To better understand the relationship between NF1 and composite pheochromocytoma, an immunohistochemical study using anti-neurofibromin that is an NF1 gene product and DNA sequence of NF1 Exon 31 were carried out in five cases of composite pheochromocytoma and in various tumors from five patients with NF1. Neurofibromin was not expressed in Schwann cells and sustentacular cells of composite pheochromocytomas and was very weakly or negatively expressed in neurofibroma of NF1 patients. However, it was strongly expressed in ganglionic cells and pheochromocytoma cells of the composite pheochromocytomas and also in mucosal ganglioneuromas, a gangliocytic paraganglioma, and in pheochromocytomas from the patients with NF1. Although there was no mutation in NF1 Exon 31, it could not be ruled out that there were mutations in other sites of the NF1 gene. Neurofibromin insufficiency may induce abnormal proliferation of Schwann cells in composite pheochromocytomas as well as in neurofibromatosis.

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The distribution of immunoreactive chromogranins, S-100 protein, and vasoactive intestinal peptide in compound tumors of the adrenal medulla

Cited by 33 publications

References 20 publications

Class III β‐Tubulin isotype (β III) in the adrenal medulla: II. Localization in primary human pheochromocytomas

Class III β‐Tubulin isotype (β III) in the adrenal medulla: II. Localization in primary human pheochromocytomas

Results of Surgery for a Compound Adrenal Tomor Consisting of Pheochromocytoma and Ganglioneuroblastoma in an Adult. 5-year Follow-up.

Neurofibromin and NF1 Gene Analysis in Composite Pheochromocytoma and Tumors Associated with von Recklinghausen's Disease

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