The Distribution of Immunoglobulin-Containing Cells Along the Human Gastrointestinal Tract

Crabbé, P. A.; Heremans, J. F.

doi:10.1016/s0016-5085(19)34386-0

Cited by 230 publications

(44 citation statements)

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“…Moreover, we found that the number of IgA-secreting cells, quantified by using a hemolytic plaque forming cell assay, was significantly higher in the proximal segment. Our results are in agreement with several reports, which show that the majority of IgA-producing cells are located in the proximal segment of the small intestine [15,16,[18][19][20][21]23]. Finally, the expression of the mRNA for alpha-chain was higher in the proximal segment, which suggests that each plasma cell produces more IgA.…”

Section: Discussionsupporting

confidence: 93%

“…For instance, in the ileum the distribution of IgA 1 and IgA 2 subclasses is different than in the duodenum and jejunum [15]. Also, there is a relatively high proportion of IgM-producing cells in the duodenum of humans and mice [15][16][17] and a clearly progressive decrease in the density of IgA-containing cells from duodenum to ileum in the small intestine of humans and several other species [15,16,[18][19][20][21][22][23]]. …”

Section: Introductionmentioning

confidence: 99%

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Regionalization of pIgR expression in the mucosa of mouse small intestine

et al. 2010

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Regionalization of pIgR expression in the mucosa of mouse small intestine

et al. 2010

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“…Since IgA predominates in the plasma cells of normal human intestinal mucosa (Crabbe, Carbonara, and Heremans, 1965;Crabbe and Heremans, 1966;Gelzayd, Kraft, and Fitch, 1967) a study of serum IgA concentrations was of particular interest in the present investigation. The presence of a consistently increased serum immunoglobulin concentration in patients with ulcerative colitis would provide further evidence of immunological disorder in this disease and would also be of potential diagnostic value.…”

Section: Discussionmentioning

confidence: 99%

A clinico-immunological study of ulcerative colitis and ulcerative proctitis

Smith¹,

MacPhee²

1971

Gut

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summ,ARY Fifteen patients with ulcerative colitis and 11 patients with ulcerative proctitis have been observed and studied for periods ranging from one to 15 years. It is suggested that the clinical course of the two disorders is quite distinct. Further, while the serum immunoglobulins were within normal limits in ulcerative proctitis, significant increases in the serum 012-, P-, and y-globulins and in the IgA and IgG concentrations were found in ulcerative colitis.Despite total colectomy for ulcerative colitis, the serum IgG and IgA concentration remained high and even after subsequent rectal resection the relative IgA concentration continued to increase. The significance of these findings is discussed.Bloody diarrhoea without systemic disturbance and with mucosal changes confined to the rectum may not progress to frank ulcerative colitis. Haemorrhagic or ulcerative proctitis can, we believe, be differentiated from ulcerative colitis, even in its milder forms, on clinical and serological grounds. Autoimmune factors may be involved in the aetiology of ulcerative colitis but the results from tests in vitro for serum antibodies against alimentary antigens have been inconclusive (Polcak

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“…Received for publication 11 March 1983 in the presence of gluten produces both IgA and IgM gliadin antibody.5 One might therefore expect to find an increase in the concentration of IgA, and possibly IgM, plasma cells in the mucosa of untreated coeliac patients with a fall to normal following treatment. Unfortunately the results of different studies of mucosal plasma cells in coeliac disease are very conflicting, no two studies agreeing.3 $9 Furthermore, even the studies of mucosal plasma cells in control subjects vary greatly the ratio of IgA:IgG plasma cells varying from 3 :1 to 30:1.6 [8][9][10][11][12] This confliction may be explained partly by the small numbers of subjects studiedsix to 13 for coeliac patients and six to 17 for controls. Probably of more importance are problems of technique.…”

mentioning

confidence: 99%