The distribution of fos immunoreactivity in rat brain following freezing and escape responses elicited by electrical stimulation of the inferior colliculus

Lamprea, Marisol; Cardenas, F.P.; Vianna, Daniel Machado Luiz; Castilho, V.M.; Cruz-Morales, Sara E.; Brandão, Marcus Lira

doi:10.1016/s0006-8993(02)03036-6

Cited by 73 publications

(34 citation statements)

References 78 publications

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“…We could show that tones meet this criterion, as they are able to elicit freezing in naive mice. In line with this observation, Lamprea et al (2002) demonstrated in naive rats that electric stimulation of the inferior colliculus, a central relay station of auditory inputs to thalamic and cortical structures, with currents of rising intensity, induces the whole spectrum of behavioral fear responses, including freezing. In our experiments, the freezing response of nonshocked mice to a loud tone was similar to that of shocked mice to a tone of intermediate volume, indicating that the footshock sensitized the animals to the tone.…”

Section: Discussionmentioning

confidence: 55%

Nonassociative learning processes determine expression and extinction of conditioned fear in mice

Kamprath¹,

Wotjak²

2004

Learn. Mem.

166

151

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Freezing to a tone following auditory fear conditioning is commonly considered as a measure of the strength of the tone-shock association. The decrease in freezing on repeated nonreinforced tone presentation following conditioning, in turn, is attributed to the formation of an inhibitory association between tone and shock that leads to a suppression of the expression of fear. This study challenges these concepts for auditory fear conditioning in mice. We show that acquisition of conditioned fear by a few tone-shock pairings is accompanied by a nonassociative sensitization process. As a consequence, the freezing response of conditioned mice seems to be determined by both associative and nonassociative memory components. Our data suggest that the intensity of freezing as a function of footshock intensity is primarily determined by the nonassociative component, whereas the associative component is more or less categorical. We next demonstrate that the decrease in freezing on repeated nonreinforced tone presentation following conditioning shows fundamental properties of habituation. Thus, it might be regarded as a habituation-like process, which abolishes the influence of sensitization on the freezing response to the tone without affecting the expression of the associative memory component. Taken together, this study merges the dual-process theory of habituation with the concept of classical fear conditioning and demonstrates that sensitization and habituation as two nonassociative learning processes may critically determine the expression of conditioned fear in mice.

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Section: Discussionmentioning

confidence: 55%

Nonassociative learning processes determine expression and extinction of conditioned fear in mice

Kamprath¹,

Wotjak²

2004

Learn. Mem.

166

151

View full text Add to dashboard Cite

show abstract

“…Photographs of the areas of interest were taken at 4X magnification using an Olympus DP70 camera connected to an Olympus AX70 bright-field microscope (analySIS; Imaging System, Münster, Germany). Our quantification method was similar to a previously reported method, with minor modifications (Lamprea et al, 2002). Four sections from each animal were selected for quantification.…”

Section: Quantitative Evaluation Of C-fos Immunoreactive Cellsmentioning

confidence: 99%

High frequency stimulation of the ventrolateral and mediodorsal thalamic nuclei: differential effects on impulsive action

Sesia¹,

Başar²,

Vlamings³

et al. 2009

jecm

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Ventrolateral thalamic nucleus stimulation is a frequently applied clinical procedure to control disabling tremor. Its motor effects are largely established now, but the cognitive effects are largely unknown and are currently under investigation. Here, we performed a detailed investigation of the effects of electrical stimulation at high frequency (130 Hz) and various amplitude (0, 1, 3, 30, 150) of the VL thalamic nucleus in a rat model on specific cognitive functions, using a reaction time task, and compared to DBS of the mediodorsal thalamic nucleus (MD) to evaluate the specificity of the site of stimulation. The involvement of the MD thalamic nucleus in cognitive functions has already been established. In addition, we mapped the effect of VL and MD thalamic nuclei DBS on the neuronal activity of the mPFC using c-Fos immunohistochemistry to investigate the neural pathways underlying the behavioural effects. Results show that DBS of the VL and MD thalamic nuclei had no significant effects on reaction time and motor time. DBS of the VL thalamic nucleus induced no significant effect on premature responding, whereas DBS of the MD thalamic nucleus increased this. In addition, MD and VL thalamic nuclei DBS significantly increased the number of c-Fos-immunoreactive cells in the prelimbic cortex as compared to control animals. In the infralimbic cortex, the number of c-Fos-immunoreactive cells was significantly higher following MD thalamic nucleus DBS as compared to the other groups. These findings support that the VL thalamic nuclei is not involved in impulsive action. However, DBS of the MD thalamic nucleus induced specific changes in cognitive parameters, which further establishes its involvement in behavioral functions.. This behavioral effect is mediated by a circuit involving specific prefrontal cortical areas.

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“…As medidas complementares avaliadas no LCE, tais como a exploração da extremidade dos braços abertos, esticamentos e autolimpeza permitem uma análise etofarmacológica mais aprofundada de diferentes aspectos da ansiedade e do modo de ação de drogas ansiolíticas (Cruz et al, 1994;Rodgers & Johnson, 1995;Anseloni & Brandão, 1997;. Outro modelo largamente empregado no estudo das reações defensivas incondicionadas é o procedimento de estimulação elétrica, ao qual o CI é particularmente responsivo Lamprea et al, 2002) e que também é sensível à ação antiaversiva dos benzodiazepínicos Pandossio & Brandão, 1999). Além disso, a observação do funcionamento basal da resposta eletrofisiológica evocada por estimulação acústica aversiva no colículo inferior é uma medida útil ao se tratar de uma estrutura dedicada à recepção de informações sensoriais auditivas (Meeren et al, 2001;Nobre & Brandão, 2011).…”

Section: Componentes Sensoriais E Motores Da Expressão Das Reações Deunclassified

“…Cinco dias após a cirurgia, cada animal foi mantido em habituação por 5 minutos em uma caixa quadrada de acrílico (25 × 20 × 20 cm (Lamprea et al, 2002;.…”

Section: Equipamentos E Procedimentosunclassified

“…Indeed, rats submitted to the EPM without any acoustic stimulation present increased Fos activity in the IC, among other structures involved in the defense reaction . Other Fos expression studies have also disclosed neural circuits underlying the freezing behavior elicited by stimulation of distinct regions of the IC FerreiraNetto et al, 2007;Lamprea et al, 2002). NMDA injections aimed at the dorsal part of the IC (ICd) caused an increase of Fos expression in the medial geniculate nucleus, superior colliculus, dPAG and locus coeruleus, while injections of NMDA into the ventral region of IC (ICv) resulted in increased Fos expression in the prelimbic and cingulate cortices, basolateral and medial nuclei of AMYG, ventrolateral PAG, cuneiform nucleus and locus coeruleus .…”

Section: Introductionmentioning

confidence: 99%

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Papel dos mecanismos GABAérgicos do colículo inferior e da substância cinzenta periaquedutal na interface sensoriomotora do medo e ansiedade

Saito¹

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The distribution of fos immunoreactivity in rat brain following freezing and escape responses elicited by electrical stimulation of the inferior colliculus

Cited by 73 publications

References 78 publications

Nonassociative learning processes determine expression and extinction of conditioned fear in mice

Nonassociative learning processes determine expression and extinction of conditioned fear in mice

High frequency stimulation of the ventrolateral and mediodorsal thalamic nuclei: differential effects on impulsive action

Papel dos mecanismos GABAérgicos do colículo inferior e da substância cinzenta periaquedutal na interface sensoriomotora do medo e ansiedade

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