The distribution of dichlorvos in the tissues of mammals after its inhalation or intravenous administration

Blair, D.; Hoadley, Elizabeth C.; Hutson, D. H.

doi:10.1016/0041-008x(75)90160-x

Cited by 44 publications

(21 citation statements)

References 14 publications

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“…Environmental Fate and Potential for Human Exposure: Dichlorvos is rapidly absorbed and degraded in all mammalian species (FAO/WHO, 1993). Dichlorvos metabolism after different routes of administration in man, rat, mouse, swine and hamsters has been reported to be rapid, with similar metabolites in all species (Blair et al, 1975;Hutson et al, 1971a;Hutson and Hoadley, 1972a;1972b;Hutson et al, 1971b;Page et al, 1971;Page et al, 1972). Dichlorvos degradation follows two main pathways.…”

Section: Other Informationmentioning

confidence: 99%

“…Disregarding the high levels in heart and spleen which could be due to diffusion from the stomach, the insecticide was most concentrated in the lung and kidneys, with relatively low concentrations in the blood, liver and brain tissues (Shimuzu et al, 1996). Dichlorvos was found mostly in the kidneys of male rats and mice after inhalation or intravenous injection (Blair et al, 1975). Half-life times analyzed in vitro ranged from 31 minutes in blood of male rats to 1.7 minutes in rabbit blood (Blair et al, 1975).…”

Section: C) Tissue Distributionmentioning

confidence: 99%

“…Studies of tissue distribution of dichlorvos in animals indicates rapid clearance and no significant storage of this pesticide in body tissues (Blair et al, 1975;Hutson et al, 1971a;1971b;Hutson and Hoadley, 1972a;1972b). One study estimated the half-life of dichlorvos in adipose tissue of animals to be 10.7 days (GarciaRepetto et al, 1995).…”

Section: B) Adipose Tissuesmentioning

confidence: 99%

“…The clinical pharmacology of dichlorvos has been tested directly in human volunteers in many studies (Blair et al, 1975;Hutson and Hoadley, 1972a;Slomka and Hine, 1981). The effect of this insecticide on blood enzymes was tested again in human volunteers who were given small doses of dichlorvos recently, drawing criticism from media and environmental groups (Cushman, 1998).…”

Section: Storage and Excretion Of Dichlorvos In Humansmentioning

confidence: 99%

“…Dichlorvos is rapidly broken down in human blood, with a halflife of 7 to 11 minutes (Blair et al, 1975). A human male volunteer was monitored after receiving an oral dose of [ 14 C]-dichlorvos.…”

Section: Storage and Excretion Of Dichlorvos In Humansmentioning

confidence: 99%

See 4 more Smart Citations

Critical Evaluation of Dichlorvos’ Breast Cancer Risk

Gandhi

Snedeker

2002

Comments on Toxicology

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Section: Other Informationmentioning

confidence: 99%

Section: C) Tissue Distributionmentioning

confidence: 99%

Section: B) Adipose Tissuesmentioning

confidence: 99%

Section: Storage and Excretion Of Dichlorvos In Humansmentioning

confidence: 99%

Section: Storage and Excretion Of Dichlorvos In Humansmentioning

confidence: 99%

See 3 more Smart Citations

Critical Evaluation of Dichlorvos’ Breast Cancer Risk

Gandhi

Snedeker

2002

Comments on Toxicology

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Receptor interaction profile and CNS general pharmacology of metrifonate and its transformation product dichlorvos in rodents

et al. 1996

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Organophosphorus Compounds

Storm¹

2001

Patty's Toxicology

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Organophosphate pesticides are a highly diverse group of chemicals to which workers may be exposed during manufacture and formulation and during or after application for their intended uses. They are all characterized by their ability to inhibit the enzyme acetylcholinesterase (AChE) that deactivates the neurotransmitter acetylcholine (ACh). Compounds in this class are numerous and have been categorized in many ways according to the nature of the substituents. Gallo and Lawryk, for example, categorized them into four main categories (Groups I‐IV) based on the characteristics of the leaving group (X). Group I compounds, phosphorylcholines, have a leaving group that contains a quaternary nitrogen and are among the most potent organophosphates (e.g., Shradan). Group II compounds, fluorophosphates, have a fluoride leaving group and are also generally highly toxic (e.g., diisopropyl fluorophosphate). Group III compounds have leaving groups that contain cyanide or a halogen other than fluoride and are generally less potent than Groups I or II (e.g., Parathion). Group IV contains most of the organophosphates used as insecticides today. These compounds have alkoxy, alkylthio, aryloxy, arylthio or heterocyclic leaving groups and a wide variety of other substituents. Another classification scheme is based on the nature of the atoms that immediately surround the central phosphorus atom and results in 14 different categories. According to this scheme, phosphates are the prototype for the entire class and are those compounds where all four atoms that surround the phosphorus atom are oxygen (e.g., dichlorvos, mevinphos). Sulfur‐containing organophosphate compounds (phosphorothioates; phosphorothiolates; phosphorodithioates; phosphorodithiolates) are far more numerous than phosphates and include well recognized organophosphate insecticides such as parathion, diazinon, chlorpyrifos, etc. Other groups contain nitrogen (phosphoramides and phosphorodiamides), nitrogen and sulfur (phosphoramidothionates and phosphoramidothiolates), carbon (phosphonates and phosphinates), or carbon and sulfur (phosphonothionates, phosphonothionothiolates and phosphinothionates). All aspects of organophosphate chemistry, toxicity, analysis, and exposure potential have been previously reviewed. Additionally information regarding the toxicity of this class of compounds has expanded greatly in recent years as a result of toxicity data supplied by registrants to the U.S. EPA's Office of Pesticides to support reregistration. These data are being made publically available by the U.S. EPA on their internet web site. The following discussion draws heavily from recent reviews but also includes summaries of relevant toxicity data submitted to the U.S. EPA available when this chapter was completed. Due to space limitations detailed data reviews are included here for only 30 organophosphate pesticides. Information on other pesticides registered or undergoing reregistration in the United States can be readily obtained from the previously mentioned website.

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The distribution of dichlorvos in the tissues of mammals after its inhalation or intravenous administration

Cited by 44 publications

References 14 publications

Critical Evaluation of Dichlorvos’ Breast Cancer Risk

Critical Evaluation of Dichlorvos’ Breast Cancer Risk

Receptor interaction profile and CNS general pharmacology of metrifonate and its transformation product dichlorvos in rodents

Organophosphorus Compounds

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