The distribution of blood group antigens and alloantibodies among Chinese in Taiwan

Lin‐Chu, M.; Broadberry, Richard E.; Chang, Fu-Wu

doi:10.1046/j.1537-2995.1988.28488265265.x

Cited by 65 publications

(58 citation statements)

References 2 publications

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“…The nonsecrctor Lc(a+b-) phenotype, contrary to our previous report [1], is ab sent (or very rare) among Chinese in Tai wan. The reason for this discrepancy is due to the variation in strength of the Lc1 ' antigen in the Le(a+b+) phenotype.…”

Section: Discussioncontrasting

confidence: 99%

“…If there was no inhi bition in any of the dilutions of antisera or lectin when compared with the saline control tubes of each dilution, then it was concluded that no salivary substance was present. We also retested with the above goat anti-Lea and anti-l.e1 ' the RBCs from several Chinese donors that we had previously re ported [1] as Le(a-l-b-). This was because in that re port a microplate technique had been used in which the Ortho goat anti-Le1 ' had been diluted 1:3 (stan dardized to detect the Le1 ' antigen of Caucasian Lc (a -b + ) RBCs but not of oriental Lc(a+b+) RBCs) and it had been noticed that, although the majority of the RBCs of these apparently *Le(a+b-)' individ uals gave a streaming pattern characteristic of a negative reaction, a small amount of the RBCs stuck to the center of the microplate well.…”

Section: Methodsmentioning

confidence: 99%

“…Our recent report on the red blood cell (RBC) Lewis phenotypes estimated the frequencies of the Le(a+b-) and Le(a+b+) phenotypes among Chinese in Taiwan to be approximately 10 and 15%, respectively [1], As a result, it was decided to investigate whether or not a weak secre tor gene (Se10), as postulated by Sturgeon and Arcilla [2], was responsible for the Le(a+b+) in this population, and so RBC and salivary ABH and Lewis phenotypes of 100 healthy Chinese were determined.…”

Section: Introductionmentioning

confidence: 99%

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The Lewis Blood Group System among Chinese in Taiwan

Broadberry

Lin‐Chu²

1991

Hum Hered

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The nonsecretor gene se is absent (or very rare) among Chinese in Taiwan and the previously reported Le(a+b–) phenotype in this population is in fact Le(a+b+) as proven by the presence of small amounts of Le^b antigen on red blood cells. Salivary ABH substances in this phenotype are usually (although not always) markedly reduced. The Chinese Le(a+b+) phenotype is postulated to be the result of a weak secretor gene Se^ω. Although the Le(a+b+) phenotype is very rare in Caucasians, it has a frequency of 25% in Chinese. All Le(a–b–) Chinese are ABH secretors and have varying amounts of Le^a and/or Le^b substances in saliva.

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Section: Discussioncontrasting

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Lewis Blood Group System among Chinese in Taiwan

Broadberry

Lin‐Chu²

1991

Hum Hered

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“…The rate of significant red cell alloantibodies was 6% in this study, much higher than other reports of similar eth nic groups [12]. The difference may have something to do with sampling, since all our patients received multiple transfusions rather than routine antibody screening.…”

Section: Discussioncontrasting

confidence: 66%

Red Cells, HLA and Platelet Antibody Formation in Patients with Multiple Transfusions

Chow

Hu²,

Lyou³

et al. 1994

Acta Haematol

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Totally 436 Chinese patients having received multiple transfusions of red cells and platelets on more than three occasions were screened for red cell antibodies. Twenty-six (6%) of them were positive. Anti-E, -Mia, and -c were the common alloantibodies. Nine patients were immunized during the period of regular transfusions, with a newly immunized rate of 2% (9/436). Among 436 patients, 387 were screened for HLA antibodies by lymphocytotoxicity test (LCT). The overall positive rate was 35%. Most of the antibodies identified were against the high-frequency HLA antigens in the Chinese population. About 10% of the LCT-positive cases reverted to negative state during the follow-up period. After chloroquine stripping of the target platelets, mixed passive hemagglutination assay was used to detect platelet antibodies other than HLA antibody. Fifty-eight of 161 cases (36%) were positive for platelet antibodies, but half of them disappeared within 1 month. Nineteen of the 58 patients had sepsis and 2 had jaundice. These findings suggested that HLA and platelet antibodies are common among Chinese, though their clinical significance and the role in platelet damage are doubtful.

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“…Our findings indicate that the frequency of the Lewis-negative trait, obtained by molecular analysis of the three FUT3 SNPs studied, was about 10.8% in the population sample studied, which is close to the serological phenotype frequencies previously described for Asiatic populations (Lin-Chu et al, 1988;Liu et al, 1996Liu et al, , 1999.…”

Section: Discussionsupporting

confidence: 88%

Article Molecular analysis of three FUT3 gene single nucleotide polymorphisms and their relationship with the lewis erythrocytary phenotype in a human population of japanese-ancestry living in Tomé Açu, a town in the Brazilian Amazon

et al. 2007

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The Lewis blood group system involves two major antigens, Le a and Le b . Their antigenic determinants are not primary gene products but are synthesized by the transfer of sugar subunits to a precursory chain by a specific enzyme which is the product of the FUT3 gene (Lewis gene). The presence of three FUT3 gene single nucleotide polymorphisms (SNPs) (59T > G; 508G > A and 1067T > A) was related to the Lewis phenotype of erythrocytes from 185 individuals of Japanese ancestry living in the town of Tomé-Açu in the Brazilian Amazon region. This relationship was detected using a serological hemagglutination test and the Dot-ELISA assay along with the molecular technique PCR-RFLP. We found that the three SNPs investigated in this study only accounted for a proportion of the Lewis-negative phenotype of the erythrocytes.

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The distribution of blood group antigens and alloantibodies among Chinese in Taiwan

Cited by 65 publications

References 2 publications

The Lewis Blood Group System among Chinese in Taiwan

The Lewis Blood Group System among Chinese in Taiwan

Red Cells, HLA and Platelet Antibody Formation in Patients with Multiple Transfusions

Article Molecular analysis of three FUT3 gene single nucleotide polymorphisms and their relationship with the lewis erythrocytary phenotype in a human population of japanese-ancestry living in Tomé Açu, a town in the Brazilian Amazon

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