The Distribution of Asterosaponins, Polyhydroxysteroids and Related Glycosides in Different Body Components of the Far Eastern Starfish Lethasterias fusca

Popov, Roman S.; Ivanchina, Natalia V.; Kicha, A. A.; Malyarenko, Timofey V.; Grebnev, Boris B.; Stonik, Valentin A.; Dmitrenok, Pavel S.

doi:10.3390/md17090523

Cited by 8 publications

(11 citation statements)

References 29 publications

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“…Previously, we studied the metabolic profile of polar steroid compounds of three species of starfish and their changes under stress conditions, as well as the metabolic profile of triterpene glycosides from the sea cucumber Eupentacta fraudatrix [8][9][10][11][12][13]. The study of the metabolomic profiles of sphingolipids and their changes under various environmental conditions can also be one of the directions of metabolomics research.…”

Section: Discussionmentioning

confidence: 99%

“…Asteriaceramide A (2) showed a stimulatory activity toward root growth of Brassica campestris. The plant growth activity of the A sphingosine-type ceramide LMCer-1-1 (12) and three phytosphingosine-type ceramides, LMCer-2-1 (13), LMCer-2-6 (14), and LMCer-2-7 (15), were isolated from the ceramide molecular species LMCer-1 (16) and LMCer-2 (17), obtained from the chloroformmethanol extract of the whole bodies of Luidia maculata [35]. The structures of ceramides 12-15 were determined on the basis of spectroscopic and chemical evidence as (14), and (2S,3S,4R)-2-[(2R)-2hydroxydocosanoylamino]-14-methyl-hexadecane-1,3,4-triol (15) (Figure 2).…”

Section: Class Asteroideamentioning

confidence: 99%

“…Our group is carrying out long-term studies on natural products from echinoderms [1][2][3][4][5][6], but sphingolipids from these invertebrates [7] so far were not in our main spotlight. However, our recent metabolomic studies on secondary metabolites from echinoderms, showing their extremal diversity [8][9][10][11][12][13], and successful attempts of application of some compounds as chemotaxonomic markers required the examination of perspectives of similar use of sphingolipids.…”

Section: Introductionmentioning

confidence: 99%

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Sphingolipids of Asteroidea and Holothuroidea: Structures and Biological Activities

et al. 2021

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Sphingolipids are complex lipids widespread in nature as structural components of biomembranes. Commonly, the sphingolipids of marine organisms differ from those of terrestrial animals and plants. The gangliosides are the most complex sphingolipids characteristic of vertebrates that have been found in only the Echinodermata (echinoderms) phylum of invertebrates. Sphingolipids of the representatives of the Asteroidea and Holothuroidea classes are the most studied among all echinoderms. In this review, we have summarized the data on sphingolipids of these two classes of marine invertebrates over the past two decades. Recently established structures, properties, and peculiarities of biogenesis of ceramides, cerebrosides, and gangliosides from starfishes and holothurians are discussed. The purpose of this review is to provide the most complete information on the chemical structures, structural features, and biological activities of sphingolipids of the Asteroidea and Holothuroidea classes.

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Section: Discussionmentioning

confidence: 99%

Section: Class Asteroideamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sphingolipids of Asteroidea and Holothuroidea: Structures and Biological Activities

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“…The highest level of polar steroids and their glycoconjugates was found in the stomach. Asterosaponins were found in all other body components; the main share of free polyhydroxysteroids and related glycosides were located in the pyloric caeca [12].…”

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confidence: 99%

“…The third article concerns the function of the immunity of a lectin in producing this compound crinoid. Two articles concern steroid glycosides from starfish [11,12], and two others concern triterpene glycosides from sea cucumbers [13,14]. One article describes the effect of a glycosaminoglycan from the sea cucumber Apostichopus japonicus on hyperglycemia in the liver of insulin-resistant mice [17].…”

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confidence: 99%

Marine Glycoconjugates: Trends and Perspectives

2020

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Glycoconjugates play significant roles in biological systems and are used in medicine, for example as vaccines. Glycoproteins, peptidoglycans, lipopolysaccharides, and other biopolymer glycoconjugates are responsible for cellular interactions, including cell-cell recognition and the binding of cells to the intercellular matrix. These molecules perform signal, antigenic and transport functions, and participate in the formation of receptors and other important membrane and blood constituents. Due to the negative charges of some sulfated glycoconjugates and the binding of water, they are critical for maintaining the physical status of connective tissue [1]. Low molecular weight glycoconjugates, such as triterpene and steroidal glycosides [2][3][4], glycolipids, are also well known as molecules playing important internal and exterior roles. Diverse glycoconjugates show a very wide spectrum of biological activities, including defensive, cytotoxic, antitumor, immunomodulatory, and antioxidant properties. The water environment requires high solubility for signal or anti-predatory exometabolites of marine organisms, and carbohydrate moieties provide this property. All these peculiarities explain the very wide diversity of glycoconjugates of marine origin, including those presented in the current Special Issue.Sterol and sphingolipid glycoconjugates, which are widespread, but insufficiently studied metabolites of microalgae, were discussed by Stonik and Stonik in the review article. Glycosylated sterols play important biological roles in microalgae and show different beneficial properties useful for medicine and healthy food. Dietary sterols and their glycoconjugates of microalgae enter into marine invertebrates through food chains and may be converted into 7(8)-unsaturated sterols and their derivatives, such as polyhydroxylated sterols and, probably, glycosides of starfishes and sea cucumbers. The knowledge of microalgal glycosphingolipids still remains poor, despite intensive investigations. Some of them are important for their interactions with pathogens and may induce apoptosis in microalgae. They also participate in the termination of microalgal blooms [5].In their experimental article, Galasso et al. have discussed the obtaining and properties of a water-soluble bioactive fraction isolated from the toxic dinoflagellate Alexandrium minutem. This substance is a glycoprotein with a molecular weight above 20 kDa. It demonstrates specific antiproliferative activity (IC 50 = 0.4 µg/mL) against the A549 cell line (the human lung adenocarcinoma cells). Moreover, the glycoconjugate did not reveal a cytotoxicity against human normal lung fibroblasts (WI38), but induced cell death, triggered by mitochondrial autophagy (mitophagy) in tumor cells. No mitophagic events were activated by it in normal WI38 cells [6].Kostetsky et al. from the Far East Federal University (Vladivostok, Russia) have compared the fatty acid composition and thermal transitions of membrane lipids from green macroalgae Ulva lactuca, collected in the Sea of...

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Saponin contents in the starfish Echinaster sepositus: Chemical characterization, qualitative and quantitative distribution

Dahmoune

Bachari-Houma

Chibane

et al. 2021

Biochemical Systematics and Ecology

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The Distribution of Asterosaponins, Polyhydroxysteroids and Related Glycosides in Different Body Components of the Far Eastern Starfish Lethasterias fusca

Cited by 8 publications

References 29 publications

Sphingolipids of Asteroidea and Holothuroidea: Structures and Biological Activities

Sphingolipids of Asteroidea and Holothuroidea: Structures and Biological Activities

Marine Glycoconjugates: Trends and Perspectives

Saponin contents in the starfish Echinaster sepositus: Chemical characterization, qualitative and quantitative distribution

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