The distribution of arsenic and cobalt in patients with laryngeal carcinoma

Collecchi, Paola; Esposito, Mauro; Brera, Silvio; Mora, Enzo; Mazzucotelli, A.; Oddone, Massimo

doi:10.1002/jat.2550060410

Cited by 11 publications

(3 citation statements)

References 6 publications

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“…After absorption (from all intake routes), Co is mainly disseminated to the serum, whole blood, liver, kidneys, heart and spleen. Lower concentrations are observed in the skeleton, hair, lymphatic circulation, brain and pancreas 2,112,134,[142][143][144][145][146][147][148][149] . The kidneys are predominantly responsible for the excretion of absorbed cobalt 4, 116 .…”

Section: Dietary Exposurementioning

confidence: 99%

Cobalt toxicity in humans—A review of the potential sources and systemic health effects

et al. 2017

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Cobalt (Co) and its compounds are widely distributed in nature and are part of numerous anthropogenic activities. Although cobalt has a biologically necessary role as metal constituent of vitamin B, excessive exposure has been shown to induce various adverse health effects. This review provides an extended overview of the possible Co sources and related intake routes, the detection and quantification methods for Co intake and the interpretation thereof, and the reported health effects. The Co sources were allocated to four exposure settings: occupational, environmental, dietary and medical exposure. Oral intake of Co supplements and internal exposure through metal-on-metal (MoM) hip implants deliver the highest systemic Co concentrations. The systemic health effects are characterized by a complex clinical syndrome, mainly including neurological (e.g. hearing and visual impairment), cardiovascular and endocrine deficits. Recently, a biokinetic model has been proposed to characterize the dose-response relationship and effects of chronic exposure. According to the model, health effects are unlikely to occur at blood Co concentrations under 300μg/l (100μg/l respecting a safety factor of 3) in healthy individuals, hematological and endocrine dysfunctions are the primary health endpoints, and chronic exposure to acceptable doses is not expected to pose considerable health hazards. However, toxic reactions at lower doses have been described in several cases of malfunctioning MoM hip implants, which may be explained by certain underlying pathologies that increase the individual susceptibility for Co-induced systemic toxicity. This may be associated with a decrease in Co bound to serum proteins and an increase in free ionic Co. As the latter is believed to be the primary toxic form, monitoring of the free fraction of Co might be advisable for future risk assessment. Furthermore, future research should focus on longitudinal studies in the clinical setting of MoM hip implant patients to further elucidate the dose-response discrepancies.

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Section: Dietary Exposurementioning

confidence: 99%

Cobalt toxicity in humans—A review of the potential sources and systemic health effects

et al. 2017

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“…Contrary to our studies an increased level of cobalt in laryngeal carcinoma in comparison with the healthy tissue was reported in the studies by Rostowska-Nadolska and Pośpiech [18] and Collecchi et al . [20]. …”

Section: Discussionmentioning

confidence: 99%

The content of cadmium, cobalt and nickel in laryngeal carcinoma

Klatka¹,

Remer²,

Dobrowolski³

et al. 2011

aoms

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IntroductionThe aim of the study was to determine the content of cadmium (Cd), cobalt (Co) and nickel (Ni) in the samples from laryngeal carcinoma in comparison with the level of these elements in the samples of healthy mucous membrane from the same larynx.Material and methodsThe study was conducted on 43 patients with laryngeal carcinoma. The levels of Cd, Co, and Ni in carcinoma and healthy control tissues was determined by inductively coupled plasma optical emission spectrometry (ICP – OES) using sequential spectrometer.ResultsNo significant differences were found between the levels of the Cd, Co, and Ni in laryngeal carcinoma vs tissues without carcinoma. However, it was noted that the concentration of Cd in tumors of patients with metastases to cervical lymph nodes was significantly higher than in tumors without metastases. The content of Co was significantly higher in more advanced laryngeal tumors: in stage-T4 than in stage T3. It is of interest that the levels of Cd, Co and Ni were significantly higher in tumors in patients from rural than urban areas.ConclusionsThe imbalance in the level of nickel, cadmium and cobalt in laryngeal cancer may be due to a changed cellular metabolism in the cancer process. However, the results of our study reveal the significant differences in the concentration of these metals between patients from urban and rural areas which suggests that this fact may be related to environmental or occupational factors and therefore it requires further study.

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“…Narang and Datta (1983) have reported that concentrations of arsenic in both the liver and brain of patients who died of fulminant hepatitis are high compared to patients who died of non-hepatic-related causes. Collecchi, Esposito and Brera (1986) compared the distribution of arsenic and cobalt in cancerous and noncancerous laryngeal tissue and plasma of patients with and without laryngeal cancer. Malignant tissue had significantly higher levels of arsenic compared to normal tissue and plasma arsenic levels were also significantly higher in cancer patients compared to controls.…”

Section: Tissue Distributionmentioning

confidence: 99%