The Distribution of Angiopoietin-1, Angiopoietin-2 and Their Receptors Tie-1 and Tie-2 in the Very Early Human Placenta

Seval, Yasemin; Satı, Leyla; Çelik-Özenci, Çiler; Taşkın, Ömür; Demir, Ramazan

doi:10.1016/j.placenta.2008.06.009

Cited by 55 publications

(49 citation statements)

References 36 publications

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“…It is very likely that they play important roles in the molding of blood vessels. These results were consistent with the results of a previous study (Seval et al, 2008). Most studies on this topic have demonstrated that Ang-2 and Tie-2 had the ability to promote the growth of tumors.…”

Section: Discussionsupporting

confidence: 93%

Expression of Ang-2/Tie-2 and PI3K/AKT in Colorectal Cancer

Zhang

Wang²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 93%

Expression of Ang-2/Tie-2 and PI3K/AKT in Colorectal Cancer

Zhang

Wang²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Since during early pregnancy first vasculogenesis and then angiogenesis are initiated, it seems that high expression of VEGF and ANGPT systems is required to regulate these processes. In fact, members of the VEGF family and ANGPTs are recognized as the major regulators of vasculogenesis and angiogenesis in the placenta (Reynolds et al 2002, Zygmunt et al 2003, Demir et al 2007, Seval et al 2008. In the primate placenta, protein and/or mRNA expression of VEGF, FLT1, KDR, ANGPT1, ANGPT2, and/or receptor TEK was detected during early pregnancy (Demir et al 2004, Wei et al 2004, Seval et al 2008, Demir 2009).…”

Section: Discussionmentioning

confidence: 99%

“…In fact, members of the VEGF family and ANGPTs are recognized as the major regulators of vasculogenesis and angiogenesis in the placenta (Reynolds et al 2002, Zygmunt et al 2003, Demir et al 2007, Seval et al 2008. In the primate placenta, protein and/or mRNA expression of VEGF, FLT1, KDR, ANGPT1, ANGPT2, and/or receptor TEK was detected during early pregnancy (Demir et al 2004, Wei et al 2004, Seval et al 2008, Demir 2009). These factors appeared to be spatio-and temporal-regulated during early pregnancy in primates (Demir et al 2004, Wei et al 2004, Kayisli et al 2006, Seval et al 2008.…”

Section: Discussionmentioning

confidence: 99%

“…In the primate placenta, protein and/or mRNA expression of VEGF, FLT1, KDR, ANGPT1, ANGPT2, and/or receptor TEK was detected during early pregnancy (Demir et al 2004, Wei et al 2004, Seval et al 2008, Demir 2009). These factors appeared to be spatio-and temporal-regulated during early pregnancy in primates (Demir et al 2004, Wei et al 2004, Kayisli et al 2006, Seval et al 2008. The increased expression of several angiogenic factors during early pregnancy indicates that these factors are involved in the regulation of vascular development, remodeling, and trophoblast function.…”

Section: Discussionmentioning

confidence: 99%

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Placental development during early pregnancy in sheep: cell proliferation, global methylation, and angiogenesis in the fetal placenta

Grazul-Bilska¹,

Johnson²,

Borowicz³

et al. 2011

Reproduction

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To characterize early fetal placental development, gravid uterine tissues were collected from pregnant ewes every other day from day 16 to 30 after mating. Determination of 1) cell proliferation was based on Ki67 protein immunodetection; 2) global methylation was based on 5-methyl-cytosine (5mC) expression and mRNA expression for DNA methyltransferases (DNMTs) 1, 3a, and 3b; and 3) vascular development was based on smooth muscle cell actin immunolocalization and on mRNA expression of several factors involved in the regulation of angiogenesis in fetal membranes (FMs). Throughout early pregnancy, the labeling index (proportion of proliferating cells) was very high (21%) and did not change. Expression of 5mC and mRNA for DNMT3b decreased, but mRNA for DNMT1 and 3a increased. Blood vessels were detected in FM on days 18-30 of pregnancy, and their number per tissue area did not change. The patterns of mRNA expression for placental growth factor, vascular endothelial growth factor, and their receptors FLT1 and KDR; angiopoietins 1 and 2 and their receptor TEK; endothelial nitric oxide synthase and the NO receptor GUCY13B; and hypoxia inducing factor 1 a changed in FM during early pregnancy. These data demonstrate high cellular proliferation rates, and changes in global methylation and mRNA expression of factors involved in the regulation of DNA methylation and angiogenesis in FM during early pregnancy. This description of cellular and molecular changes in FM during early pregnancy will provide the foundation for determining the basis of altered placental development in pregnancies compromised by environmental, genetic, or other factors.

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“…In the absence of a stimulatory growth factor, the vessels regress. ANG1 and 2 have been localized to the villous trophoblast from early gestation onwards, with RT-PCR data suggesting that the ratio of their mRNAs changes in favour of ANG1 as pregnancy advances (Charnock-Jones 2002, Seval et al 2008. The TIE2 receptor is present on villous endothelial cells, and also the trophoblast, although its influence on trophoblast biology is unknown.…”

Section: Angiopoietinsmentioning

confidence: 99%

Regulation of vascular growth and function in the human placenta

Burton¹,

Charnock-Jones²,

Jauniaux³

2009

Reproduction

285

175

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During the course of 9 months, the human placenta develops into a highly vascular organ. Vasculogenesis starts during the third week post-conception. Hemangioblastic cell cords differentiate in situ from mesenchymal cells in the villous cores, most probably under the influence of vascular endothelial growth factor (VEGFA) secreted by the overlying trophoblast. The cords elongate through proliferation and cell recruitment, and connect with the vasculature of the developing fetus. A feto-placental circulation starts around 8 weeks of gestation. Elongation of the capillaries outstrips that of the containing villi, leading to looping of the vessels. The obtrusion of both capillary loops and new sprouts results in the formation of terminal villi. Branching and non-branching angiogenesis therefore play key roles in villous morphogenesis throughout pregnancy. Maternal circulating levels of VEGFA and placental growth factor vary across normal pregnancy, and in complicated pregnancies. Determining the impact of these changes on placental angiogenesis is difficult, as the relationship between levels of factors in the maternal circulation and their effects on fetal vessels within the placenta remains unclear. Furthermore, the trophoblast secretes large quantities of soluble receptors capable of binding both growth factors, influencing their bioavailability. Villous endothelial cells are prone to oxidative stress, which activates the apoptotic cascade. Oxidative stress associated with onset of the maternal circulation, and with incomplete conversion of the spiral arteries in pathological pregnancies, plays an important role in sculpting the villous tree. Suppression of placental angiogenesis results in impoverished development of the placenta, leading ultimately to fetal growth restriction. Reproduction (2009) 138 895-902

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The Distribution of Angiopoietin-1, Angiopoietin-2 and Their Receptors Tie-1 and Tie-2 in the Very Early Human Placenta

Cited by 55 publications

References 36 publications

Expression of Ang-2/Tie-2 and PI3K/AKT in Colorectal Cancer

Expression of Ang-2/Tie-2 and PI3K/AKT in Colorectal Cancer

Placental development during early pregnancy in sheep: cell proliferation, global methylation, and angiogenesis in the fetal placenta

Regulation of vascular growth and function in the human placenta

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