The distribution of allelic variants of genes HLA-DRB1, HLA-DQA1, HLA-DQB1 and HLA-G among women with idiopathic recurrent pregnancy loss

Terpylyak, O. I.; Sosnina, K. O.; Zastavna, D. V.; Helner, N. V.; Mikula, Michał

doi:10.7124/bc.000832

Cited by 4 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In total, forty-four studies were enrolled for regarding the association of RM and 14 bp ins/del variant, six studies for rs1063320, and four citations for rs1707, rs1710, rs17179101, rs17179108, rs9380142, and rs1610696, respectively. HWE analysis indicated that seven articles [20,21,42,45,48,50,63] deviated from statistical equilibrium in the control group, and two studies [31,33] cannot compute the p value of HWE because of unavailable genotypic data. Moreover, the average NOS score of included studies was 7.14 (ranged from 5 to 9), indicating that most of the studies were of high quality.…”

Section: Eligible Study Identification and Selectionmentioning

confidence: 99%

Meta-Analysis of Human Leukocyte Antigen-G 3′UTR Polymorphisms Confer Susceptibility to Recurrent Miscarriage

Chen

Zhang

et al. 2022

Gynecol Obstet Invest

View full text Add to dashboard Cite

Objectives: The current systematic review and meta-analysis have shown that specific HLA-G 3′ UTR variants are associated with recurrent miscarriage (RM). Our aim was to investigate the relevance of HLA-G 3′ UTR polymorphisms with the risk of RM. Design: A combined meta-analysis was implemented in this study. Participants/Materials, Setting, Methods: Common electronic databases including PubMed, Embase, Web of Science, China National Knowledge Infrastructure, Cochrane Library, and Google Scholar were used to seek eligible articles up to August 2021. Results: Forty-four eligible articles with 4,467 cases and 3,955 controls were finally enrolled. Our meta-results suggested that 14 bp insertion allele was associated with elevated risk of RM (allelic model: OR = 1.18, 95% CI = 1.07–1.31, p = 0.001). Besides, a significant heterogeneity was observed between studies. Further subgroup analyses based on ethnicity revealed similar positive results in both the Caucasian and Asian subgroups but not in the Middle East subgroup. Moreover, rs1063320 G allele conferred elevated susceptibility to RM in Asian group (allelic model: OR = 1.54, 95% CI = 1.17–2.03, p = 0.002). Additionally, pooled results showed a decreased risk of RM in mothers carrying rs1710 G allele (allelic model: OR = 0.68, 95% CI = 0.55–0.85, p < 0.001) and an increased risk with rs9380142 A allele (allelic model: OR = 1.45, 95% CI = 1.15–1.83, p = 0.002). Further stratified analyses by race showed that these positive results were mainly from the associations observed in Asian populations. Limitations: The main limitation is that the enrolled number of individuals was relatively small. Thus, the results should be cautiously considered. Conclusions: Although the current systematic review and meta-analysis have shown that specific HLA-G 3′ UTR variants are associated with RM, a high degree of bias is present and further studies are needed to validate this causative effect.

show abstract