The Distribution of 10-Hydroxy Carbazepine in Blood Compartments

Jung, Hyejin; Noguez, Angélica; Mayet, Lourdes; Fuentes, Inés; González-Esquivel, Dinora F.

doi:10.1002/(sici)1099-081x(199701)18:1<17::aid-bdd997>3.0.co;2-r

Cited by 16 publications

(3 citation statements)

References 6 publications

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“…After oral administration OXC is 95% absorbed. The MHD metabolite has a low protein binding from 37 to 40% (11, 12). Although OXC does not appear to induce the cytochrome P‐450 family to the same extent as carbamazepine causing interactions with psychotropic or other types of medications (anticoagulants, thyroid hormones, antibiotics), it does induce the P‐450 III A subfamily, which is responsible for the metabolism of contraceptives and some dihydropyridine calcium‐channel blockers (13).…”

mentioning

confidence: 99%

Acute antimanic efficacy and safety of oxcarbazepine in an open trial with an on‐off‐on design

et al. 2002

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mentioning

confidence: 99%

Acute antimanic efficacy and safety of oxcarbazepine in an open trial with an on‐off‐on design

et al. 2002

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“…Schicht et al (1996) and Volosov et al (1999) indicated that cerebrospinal fluid concentrations of OXC and MHD at a steady state corresponded to the concentrations of the free drugs in plasma. Moreover, Jung et al (1997) demonstrated that MHD, after oral administration of OXD, were bound to red blood cells (RBC). Their results showed that, at all concentrations, profiles for RBC and plasma were similar, which indicates an equal distribution of MHD between erythrocytes and plasma.…”

Section: Oxcarbazepinementioning

confidence: 99%

Characteristics of selected second-generation antiepileptic drugs used in dogs

Ziółkowski

Jaroszewski²,

Ziółkowska³

et al. 2012

Polish Journal of Veterinary Sciences

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A significant number of cases of clinical canine epilepsy remain difficult to control in spite of the applied treatment. At the same time, the range of antiepileptic drugs is increasingly wide, which allows efficient treatment. In the present paper we describe the pharmacodynamics and pharmacokinetics of the newer antiepileptic drugs which were licensed after 1990 but are still not widely used in veterinary medicine. The pharmacokinetic profiles of six of these drugs were tested on dogs. The results of experimental studies suggest that second generation antiepileptic drugs may be applied in mono- as well as in poli- treatment of canine epilepsy because of the larger safety margin and more advantageous pharmacokinetic parameters. Knowledge of the drugs’ pharmacokinetics allows its proper clinical appliance, which, in turn, gives the chance to improve the efficiency of pharmacotherapy of canine epilepsy.

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“…Oxcarbazepine is rapidly and completely absorbed, reaching peak concentration within about 1−3 h after a single dose, whereas the peak of 10-hydroxycarbazepine occurs within 3−12 h [6,7]. Plasma concentrations of 10-hydroxycarbazepine were found to be much higher and to persist longer than those of unchanged oxcarbazepine after single oral administration of oxcarbazepine [2,3].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Oxcarbazepine and Its Active Metabolite 10-Hydroxycarbazepine in Human Plasma by High-performance Liquid Chromatography

Nirogi

Kandikere

Shukla

et al. 2011

Arzneimittelforschung

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A simple, sensitive and selective high-performance liquid chromatography (HPLC) method with ultraviolet detection (230 nm) was developed and validated for the quantification of oxcarbazepine (CAS 28721-07-5), a new antiepileptic drug, and its active metabolite 10-hydroxycarbazepine (CAS 29331-92-8) in human plasma. Following solid-phase extraction, the analytes and internal standard (zaleplon, CAS 151319-34-5) were separated using an isocratic mobile phase on a reverse phase C18 column. The lower limit of quantification was 50 ng/mL for oxcarbazepine and 100 ng/mL for 10-hydroxycarbazepine with a relative standard deviation of less than 10%. A linear dynamic range of 50 to 5000 ng/mL for oxcarbazepine and of 100 to 10000 ng/mL for 10-hydroxycarbazepine was established. This HPLC method was validated with between-batch precision of 0.8 to 8.6% and 3.2 to 7.5% for oxcarbazepine and 10-hydroxycarbazepine respectively. The between-batch accuracy was 94.0 to 102.4% and 95.4 to 105.6%, respectively. Stability of oxcarbazepine and 10-hydroxycarbazepine in plasma was excellent, with no evidence of degradation during sample processing (autosampler) and 30 days storage in a freezer. This validated method is sensitive, simple and repeatable enough to be used in pharmacokinetic studies.

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The Distribution of 10-Hydroxy Carbazepine in Blood Compartments

Cited by 16 publications

References 6 publications

Acute antimanic efficacy and safety of oxcarbazepine in an open trial with an on‐off‐on design

Acute antimanic efficacy and safety of oxcarbazepine in an open trial with an on‐off‐on design

Characteristics of selected second-generation antiepileptic drugs used in dogs

Quantification of Oxcarbazepine and Its Active Metabolite 10-Hydroxycarbazepine in Human Plasma by High-performance Liquid Chromatography

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