The dissolution behaviour and thermodynamic properties calculation of praziquantel in pure and mixed organic solvents

Li, Rongrong; Chen, Xianlang; He, Guanghong; Wu, Chenglin; Gan, Zhixing; He, Zhicai; Zhao, Jia; Han, Deman

doi:10.1016/j.jct.2020.106062

Cited by 48 publications

(28 citation statements)

References 31 publications

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“…In this work, the solubility of cilostazol in 1,4-dioxane, 2-butanone, acetone, 1-butanol, acetonitrile, methanol, n -propanol, ethanol, ethyl acetate, and isopropanol and mixtures of 1,4-dioane + ethanol within the temperature range from 273.15 to 313.15 K was determined using the isothermal saturation method under 101.3 kPa. − The reliability of experimental methods and apparatus has been verified in our previous published work . The detailed experimental procedure is shown in Section S2 in the Supporting information.…”

Section: Experimental Sectionmentioning

confidence: 61%

“…In this work, the solubility results in pure solvents were correlated by the modified Apelblat − and λ h equations. − Meanwhile, the data in 1,4-dioxane + ethanol binary mixtures was evaluated using the Jouyban–Acree model. − …”

Section: Resultsmentioning

confidence: 99%

“…The solubility results in binary solvent mixtures were correlated by the Jouyban–Acree model, which is an accurate and available cosolvency model. This model can provide a reasonable mathematical description for the solubility dependence on the temperature and solvent composition − where J i stands for the Jouyban–Acree model parameters, x w,T is the mole solubility of cilostazol in 1,4-dioxane + ethanol binary mixtures at the temperature range from 288.15 to 313.15 K; w 1 and w 2 are the mass fraction of 1,4-dioxane and ethanol free of cilostazol, respectively; and x 1,T and x 2,T are the mole solubility of cilostazol in the pure solvent.…”

Section: Resultsmentioning

confidence: 99%

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Solubility Measurement and the Correlation of Cilostazol in Pure and 1,4-Dioxane + Ethanol Binary Solvents from T = 273.15 to 313.15 K

Jiang

Cong

et al. 2021

J. Chem. Eng. Data

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Cilostazol is a neutral molecule with poor solubility. In this work, the solubility data of cilostazol in 10 pure and 1,4-dioxane + ethanol binary solvents was measured using the isothermal saturation method within the temperature range from 273.15 to 313.15 K at atmospheric pressure. In the 10 pure solvents, the results indicated that the maximum and minimum solubility of cilostazol appeared in 1,4-dioxane and isopropanol, respectively. The sequence of solubility was 1,4-dioxane > 2-butanone > acetone > 1-butanol > acetonitrile > methanol > n-propanol > ethanol > ethyl acetate > isopropanol. In a mixture of 1,4-dioxane + ethanol, it first increased and then decreased with increasing mass fraction of 1,4-dioxane in 1,4-dioxane + ethanol mixtures at all selected temperatures. The dissolution process of cilostazol was analyzed by the solvent properties. Moreover, the solubility data of cilostazol in the 10 pure solvents was correlated with the modified Apelblat and λh equations. The result in binary mixture at various temperatures was evaluated by the Jouyban–Acree model. In a pure solvent, the RAD values between the experimental and calculated data with modified Apelblat and λh equations were all no larger than 3.57 × 10–2 and 11.40 × 10–2, respectively. In 1,4-dioxane + ethanol binary mixtures, the RAD data of the Jouyban–Acree model was 6.22 × 10–2. The study of the dissolution process for cilostazol is an important aspect of its purification and recrystallization.

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Section: Experimental Sectionmentioning

confidence: 61%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Solubility Measurement and the Correlation of Cilostazol in Pure and 1,4-Dioxane + Ethanol Binary Solvents from T = 273.15 to 313.15 K

Jiang

Cong

et al. 2021

J. Chem. Eng. Data

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“…Experimental and predicted PZQ solubilities in organic solvents (squares, ethyl acetate; circles, 2-propanol; triangles, ethanol): (a) complete phase diagram; (b) magnified depiction. White symbols are values from literature. , The filled symbols are experimental data from Table ; solid lines were calculated with PC-SAFT using the pure-component parameters from Tables and and binary parameters from Table .…”

Section: Resultsmentioning

confidence: 99%

“…Pure-component PC-SAFT parameters for all APIs except PZQ can be taken from the literature and are listed in Table . The pure-component parameters of PZQ together with binary parameters (Table ) were fitted to solubilities in organic solvents measured in this work (Table ) and compared to data taken from the literature , (Figure b). The comparison of the experimental values revealed very good accordance with the results from literature for PZQ in 2-propanol.…”

Section: Resultsmentioning

confidence: 99%

PC-SAFT Modeling of Phase Equilibria Relevant for Lipid-Based Drug Delivery Systems

et al. 2021

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In this work we investigated the solubilities of 10 active pharmaceutical ingredients (APIs), namely, fenofibrate, ibuprofen, cinnarizine, carbamazepine, indomethacin, naproxen, griseofulvin, glibenclamide, felodipine, and praziquantel in the pharmaceutically relevant excipients tricaprylin, Lauroglycol FCC, Capryol 90, Kolliphor TPGS, ethanol, and monolaurin. API solubilities were either determined gravimetrically, with high-performance liquid chromatography, or with differential scanning calorimetry. Mutual solubilities in the three possible mixtures out of Kolliphor TPGS, tricaprylin, and carbitol as well as the vapor sorption of ethanol in tricaprylin were determined experimentally. The Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT) pure-component parameters for seven APIs were determined via fitting to vapor pressures and liquid densities or to solubilities in organic solvents. In total, 80 binary interaction parameters were fitted to the investigated binary mixtures. They can be used in the future to improve the accuracy of lipid-based drug delivery systems in-silico screenings with PC-SAFT.

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Ascorbic Acid Solubility and Thermodynamic Characteristics in Several Neat Solvents with Temperatures Ranging from 293 to 313 K

Nemdili¹,

Guedjali²,

Habchi³

et al. 2022

Int J Thermophys

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The dissolution behaviour and thermodynamic properties calculation of praziquantel in pure and mixed organic solvents

Cited by 48 publications

References 31 publications

Solubility Measurement and the Correlation of Cilostazol in Pure and 1,4-Dioxane + Ethanol Binary Solvents from T = 273.15 to 313.15 K

Solubility Measurement and the Correlation of Cilostazol in Pure and 1,4-Dioxane + Ethanol Binary Solvents from T = 273.15 to 313.15 K

PC-SAFT Modeling of Phase Equilibria Relevant for Lipid-Based Drug Delivery Systems

Ascorbic Acid Solubility and Thermodynamic Characteristics in Several Neat Solvents with Temperatures Ranging from 293 to 313 K

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