The dispensability of 14-3-3 proteins for the regulation of human cardiac sodium channel Nav1.5
Oksana Iamshanova,
Anne-Flore Hämmerli,
Elise Ramaye
et al.
Abstract:Background
14-3-3 proteins are ubiquitous proteins that play a role in cardiac physiology (e.g., metabolism, development, and cell cycle). Furthermore, 14-3-3 proteins were proposed to regulate the electrical function of the heart by interacting with several cardiac ion channels, including the voltage-gated sodium channel Nav1.5. Given the many cardiac arrhythmias associated with Nav1.5 dysfunction, understanding its regulation by the protein partners is crucial.
Aims
In this study, we aimed to investigate t… Show more
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