Objectives In order to assess progress in eliminating health disparities, a Healthy People 2010 goal, both at the national level and in Chicago, Illinois, we examined whether disparities between non-Hispanic Black and non-Hispanic White persons widened, narrowed, or stayed the same between 1990 and 2010. Methods We examined 17 health status indicators. In order to determine whether a disparity widened, narrowed, or remained unchanged between 1990 and 2010, we examined the relative percentage difference in rates at both time points and at each location. We calculated P values to determine whether changes in relative percentage difference over time were statistically significant.