The Disease-Modifying Role of Taurine and Its Therapeutic Potential in Coronavirus Disease 2019 (COVID-19)

Eijk, Larissa E. van; Offringa-Hup, Annette; Bernal, Maria-Elena; Bourgonje, Arno R.; Goor, Harry van; Hillebrands, Jan-Luuk

doi:10.1007/978-3-030-93337-1_1

Cited by 4 publications

(1 citation statement)

References 135 publications

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“…Notable among the metabolites interacting with IL-6 is taurine, an amino sulfonic acid involved in the regulation of oxidative stress, which is known to play an important role in COVID-19. Taurine levels have been reported to decrease in COVID-19 patients which potentially modulates disease progression via its antiviral, antioxidant, anti-inflammatory, and vascular-related effects (78). Other metabolites interacting with IL-6 included serotonin, a neurotransmitter, known to play important roles in the immune system and in regulating inflammatory responses (79).…”

Section: Discussionmentioning

confidence: 99%

Network-based integrative multi-omics approach reveals biosignatures specific to COVID-19 disease phases

Agamah,

Ederveen,

Skelton

et al. 2023

Preprint

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BackgroundCOVID-19 disease is characterized by a spectrum of disease phases (mild, moderate, and severe). Each disease phase is marked by changes in omics profiles with corresponding changes in the expression of features (biosignatures). However, integrative analysis of multiple omics data from different experiments across studies to investigate biosignatures at various disease phases is limited. Exploring an integrative multi-omics profile analysis through a network approach could be used to determine biosignatures associated with specific disease phases and enable the examination of the relationships between the biosignatures.AimTo identify and characterize biosignatures underlying various COVID-19 disease phases in an integrative multi-omics data analysis.MethodWe leveraged the correlation network approach to integrate transcriptomics, metabolomics, proteomics, and lipidomics data. The World Health Organization (WHO) Ordinal Scale (WOS) was used as a disease severity reference to harmonize COVID-19 patient metadata across two studies with independent data. A unified COVID-19 knowledge graph was constructed by assembling a disease-specific interactome from the literature and databases. Disease-state omics-specific graphs were constructed by integrating multi-omics data with the unified COVID-19 knowledge graph. We expanded on the network layers of multiXrank, a random walk with restart on multilayer network algorithm, to explore disease state omics-specific graphs and perform enrichment analysis.ResultsNetwork analysis revealed the biosignatures involved in inducing chemokines and inflammatory responses as hubs in the severe and moderate disease phases. We observed more shared biosignatures between severe and moderate disease phases as compared to mild-moderate and mild-severe disease phases. We further identified both biosignatures that discriminate between the disease states and interactions between biosignatures that are either common between or associated with COVID-19 disease phases. Interestingly, cross-layer interactions between different omics profiles increased with disease severity.ConclusionThis study identified both biosignatures of different omics types enriched in disease-related pathways and their associated interactions that are either common between or unique to mild, moderate, and severe COVID-19. These biosignatures include molecular features that underlie the observed clinical heterogeneity of COVID-19 and emphasize the need for disease-phase-specific treatment strategies. In addition, the approach implemented here can be used for other diseases.Key findings⍰Integrative multi-omics analysis revealed biosignatures and biosignature interactions associated with COVID-19 disease states.⍰Disease severity increases with biosignature interactions across different multi-omics data.⍰The harmonization approach proposed and implemented here can be applied to other diseases

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Section: Discussionmentioning

confidence: 99%

Network-based integrative multi-omics approach reveals biosignatures specific to COVID-19 disease phases

Agamah,

Ederveen,

Skelton

et al. 2023

Preprint

View full text Add to dashboard Cite

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Nutritional deficiencies that may predispose to long COVID

Schloss

2023

Inflammopharmacol

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Multiple nutritional deficiencies (MND) confound studies designed to assess the role of a single nutrient in contributing to the initiation and progression of disease states. Despite the perception of many healthcare practitioners, up to 25% of Americans are deficient in five-or-more essential nutrients. Stress associated with the COVID-19 pandemic further increases the prevalence of deficiency states. Viral infections compete for crucial nutrients with immune cells. Viral replication and proliferation of immunocompetent cells critical to the host response require these essential nutrients, including zinc. Clinical studies have linked levels of more than 22 different dietary components to the likelihood of COVID-19 infection and the severity of the disease. People at higher risk of infection due to MND are also more likely to have long-term sequelae, known as Long COVID. KeywordsMultiple nutritional deficiencies • Lymphocyte proliferation assay • Myeloperoxidase • Glutathione peroxidase isozyme 4 • NADPH oxidase 2 Abbreviations MND Multiple nutritional deficiencies LPA Lymphocyte proliferation assay MPO Myeloperoxidase GPX4 Glutathione peroxidase isozyme 4 NOX2 NADPH oxidase 2

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