The Disease Burden of Lung Cancer Attributable to Residential Radon Exposure in Korean Homes

Kim, Jong-Hun; Ha, Mina

doi:10.3346/jkms.2018.33.e223

Cited by 10 publications

(6 citation statements)

References 33 publications

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“…The carcinogenic effect of alpha particles derived from radon gas has been confirmed many years ago among miners [5]. Nowadays, inhalation of radon gas is the second reason for incidence of lung cancer [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Genomic Instability and Carcinogenesis of Heavy Charged Particles Radiation: Clinical and Environmental Implications

et al. 2019

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One of the uses of ionizing radiation is in cancer treatment. The use of heavy charged particles for treatment has been introduced in recent decades because of their priority for deposition of radiation energy in the tumor, via the Bragg peak phenomenon. In addition to medical implications, exposure to heavy charged particles is a crucial issue for environmental and space radiobiology. Ionizing radiation is one of the most powerful clastogenic and carcinogenic agents. Studies have shown that although both low and high linear energy transfer (LET) radiations are carcinogenic, their risks are different. Molecular studies have also shown that although heavy charged particles mainly induce DNA damage directly, they may be more potent inducer of endogenous generation of free radicals compared to the low LET gamma or X-rays. It seems that the severity of genotoxicity for non-irradiated bystander cells is potentiated as the quality of radiation increases. However, this is not true in all situations. Evidence suggests the involvement of some mechanisms such as upregulation of pro-oxidant enzymes and change in the methylation of DNA in the development of genomic instability and carcinogenesis. This review aimed to report important issues for genotoxicity of carcinogenic effects of heavy charged particles. Furthermore, we tried to explain some mechanisms that may be involved in cancer development following exposure to heavy charged particles.

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Section: Introductionmentioning

confidence: 99%

Genomic Instability and Carcinogenesis of Heavy Charged Particles Radiation: Clinical and Environmental Implications

et al. 2019

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“…Non-small cell lung cancer (NSCLC) is a malignant tumor with high incidence and mortality rates [1]. Various factors have been found act as risk factors for the development of NSCLC [2,3]. DNA damage is the primary cause for cancer development [4].…”

Section: Introductionmentioning

confidence: 99%

High Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Expression Promotes Proliferation, Migration, and Invasion of Non-Small Cell Lung Cancer via ERK/Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway

Liu¹,

Li²,

Jia³

et al. 2019

Med Sci Monit

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Background In present study, we explored the function of the metastasis-associated lung adenocarcinoma transcript 1 ( MALAT1 ) gene in the development of non-small cell lung cancer (NSCLC). Material/Methods qRT-PCR was used to detect the MALAT1 mRNA expression level in cancer tissues and adjacent normal tissues of 115 NSCLC patients and in cell lines. MALAT1 -mimic, MALAT1 -inhibitor, and corresponding negative controls (NC) were utilized to transfect the H460 cells. Proliferation, migration, and invasion of H460 cells were evaluated by MTT method and Transwell assay. Expression levels of proteins in the ERK/MAPK signaling pathway were assessed by Western blot analysis. Results MALAT1 mRNA was upregulated in NSCLC tissues and cell lines compared to that in adjacent tissues and normal human bronchial cell line (BEAS-2B), respectively. Overexpression of MALAT1 significantly strengthened the proliferation, migration, and invasion ability of H460 cells. In comparison with the NC group, expression levels of CXCL5 and p- JNK proteins were elevated, while p- MAPK and p- ERK proteins were decreased in the MALAT1 -mimic group. MALAT1 targets the 3′-untranslated region (UTR) fragment of the CXCL5 gene and inhibits its translation. Disturbance of the CXCL5 gene can reduce the protein expression of MAPK , p- MEK 1/2, p- ERK1/2, and p- JNK , and inhibit the proliferation, migration, and invasion of MALAT1 -mimic cells. Conclusions High MALAT1 expression promotes the proliferation, migration, and invasion of non-small cell lung cancer via the ERK/MAPK signaling pathway.

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“… 2 However, information based on the Korean population on those who are at high risk at the individual level and how the disease burden in the population level are limited. In this regard, the recent two papers by Choi et al 3 and Kim and Ha, 4 published in a timely manner, give us a better understanding of genetic variations in lung cancers and the disease burden associated with radon exposure in Korea.…”

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confidence: 99%

“…In general, disease burden attributable to radon exposure can be calculated by multiplying the population attributable fraction (PAF) for lung cancer, defined as the proportion of lung cancer attributable to radon exposure by the DALY in lung cancer. Kim and Ha 4 estimated the disease burden associated with lung cancer based on the national radon survey in 2011–2012. The PAF for lung cancer due to exposure to residential radon was 6.7% for men and 4.7% for women, and the total burden of lung cancer was 12,750 DALY for men and 4,022 DALY for women in 2013.…”

mentioning

confidence: 99%

“…7 The major contribution of higher PAF in Korea than the global average was relatively higher radon concentration. Given that the radon concentrations were likely to be higher in socioeconomically disadvantaged populations, 4 a radon control policy consistent with health promotion in those populations as a priority should be developed and deployed. And most of all, stop smoking is necessary to reduce overall disease burden because the majority of radon-induced lung cancers are among those also exposed to tobacco smoke.…”

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confidence: 99%

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Radon and Lung Cancer: Disease Burden and High-risk Populations in Korea

Jin

Seo

2018

J Korean Med Sci

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The Disease Burden of Lung Cancer Attributable to Residential Radon Exposure in Korean Homes

Cited by 10 publications

References 33 publications

Genomic Instability and Carcinogenesis of Heavy Charged Particles Radiation: Clinical and Environmental Implications

Genomic Instability and Carcinogenesis of Heavy Charged Particles Radiation: Clinical and Environmental Implications

High Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Expression Promotes Proliferation, Migration, and Invasion of Non-Small Cell Lung Cancer via ERK/Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway

Radon and Lung Cancer: Disease Burden and High-risk Populations in Korea

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