The discriminative stimulus properties of the atypical antipsychotic olanzapine in rats

Porter, Joseph H.; McCallum, Sarah E.; Varvel, Stephen A.; Vann, Robert E.

doi:10.1007/s002130050046

Cited by 18 publications

(11 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Drug discrimination studies seem to support this notion (Goudie and Taylor, 1998; Porter et al , 2000a; Cole et al , 2007; Goudie et al , 2007). Using a two-lever drug discrimination paradigm, Porter et al (2000a) found that the dopamine D 2 antagonists chlorpromazine and thioridazine substituted for OLZ in producing OLZ-appropriate responding in rats, as did the muscarinic cholinergic antagonist scopolamine and the 5-HT 2A/2C serotonergic antagonist ritanserin. This finding suggests that the antagonism of either dopamine D 2 receptors, muscarinic receptors, or 5-HT 2A/2C receptors is sufficient to mimic the OLZ-induced interoceptive state.…”

Section: Discussionmentioning

confidence: 93%

An investigation of the behavioral mechanisms of antipsychotic action using a drug–drug conditioning paradigm

Mead

2009

Behavioural Pharmacology

View full text Add to dashboard Cite

Antipsychotic drugs at noncataleptic doses selectively suppress conditioned avoidance response in rats. In our previous study, we had used a two-way active avoidance response paradigm to show that the antipsychotic-induced interoceptive state is one of the mechanisms underlying the avoidance-disruptive effect of antipsychotics. In this study, we sought to further examine this mechanism using a novel drug–drug conditioning procedure. We made use of the fact that both the typical neuroleptic haloperidol and the atypical neuroleptic olanzapine disrupt conditioned avoidance responding, whereas chlordiazepoxide (an anxiolytic) does not. We reasoned that if the antipsychotic interoceptive state is important in causing a disruption on avoidance responding (an index of antipsychotic efficacy), pairing chlordiazepoxide (a cueing drug conditional stimulus) with haloperidol or olanzapine (a cued drug unconditional stimulus) should engender chlordiazepoxide to exhibit this property and behave like an antipsychotic drug. Chlordiazepoxide exhibited an acquired antipsychotic-like property in disrupting avoidance responding after being repeatedly paired with haloperidol, but not with olanzapine. In contrast, it significantly attenuated the antiavoidance efficacy of olanzapine but not haloperidol after being repeatedly paired with these drugs. This study suggests that the haloperidol-induced interoceptive drug state is directly involved in its antiavoidance action, and chlordiazepoxide may attenuate the antiavoidance efficacy of antipsychotics (especially olanzapine). To the extent that the antiavoidance effect predicts clinical effects of antipsychotic treatment, this study suggests that the antipsychotic-induced interoceptive drug state may be an important behavioral mechanism mediating the clinical effects of antipsychotic treatments.

show abstract

Section: Discussionmentioning

confidence: 93%

An investigation of the behavioral mechanisms of antipsychotic action using a drug–drug conditioning paradigm

Mead

2009

Behavioural Pharmacology

View full text Add to dashboard Cite

show abstract

“…CPZ and CLZ both produce full substitution (>80% LR) in rats trained to discriminate olanzapine from vehicle in a two-choice drug discrimination task (Porter and Strong 1996;Porter et al 2000a). Moreover, both CLZ and olanzapine have produced full stimulus generalization in rats trained to discriminate CPZ from vehicle (Porter et al 1998).…”

Section: Discussionmentioning

confidence: 98%

Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in rats

et al. 2004

View full text Add to dashboard Cite

show abstract

“…In support of the compound cue hypothesis, it has been reported that rats discriminating the putative antipsychotic S-16924, which acts at many receptors, generalize fully to clozapine, and that rats discriminating clozapine generalise reciprocally to S16924 . Furthermore, rats discriminating olanzapine, which also acts at many receptors, generalise to clozapine (Porter et al 2000a).…”

Section: Introductionmentioning

confidence: 99%

Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine

2004

View full text Add to dashboard Cite

Together with data from a previous study (Smith and Goudie 2002) in which we observed full generalization to quetiapine with olanzapine, risperidone and clozapine, but not with typical antipsychotics (such as haloperidol) or the novel antipsychotic amisulpride, these data suggest that: i) the discriminative stimulus properties of quetiapine, like those of clozapine, probably reflect a "compound" stimulus which involves several classes of receptor; ii) the quetiapine cue is of value in analysing, and screening for, quetiapine- and clozapine-like agents in vivo; iii) blockade of muscarinic receptors is sufficient, although not necessary, to achieve full generalization to quetiapine; and iv) alpha(1-)adrenoceptors may be implicated in the quetiapine discriminative stimulus.

show abstract

The discriminative stimulus properties of the atypical antipsychotic olanzapine in rats

Cited by 18 publications

References 40 publications

An investigation of the behavioral mechanisms of antipsychotic action using a drug–drug conditioning paradigm

An investigation of the behavioral mechanisms of antipsychotic action using a drug–drug conditioning paradigm

Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in rats

Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine

Contact Info

Product

Resources

About