The discrimination of and orienting to speech and non-speech sounds in children with autism

Lepistö, Tuulia; Kujala, Teija; Vanhala, Raija; Alku, Paavo; Huotilainen, Minna; Näätänen, Risto

doi:10.1016/j.brainres.2005.10.052

Cited by 244 publications

(262 citation statements)

References 58 publications

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“…These findings suggest an auditory hypersensitivity to changes in pitch and impairment in involuntary orienting to speech in children with autism. Interestingly, the authors found similar in individuals with Asperger's syndrome, despite the fact that these two groups have such differences in their language abilities (Lepistö et al 2005(Lepistö et al , 2006.…”

Section: Auditory Social Cognition: Erps In Language Processingmentioning

confidence: 93%

“…Therefore, amplitude and latency of components vary based on the frequency and intensity of the sound stimulus. (Ceponiene et al 2002;Lepistö et al 2005). Studies using depth electrodes, source modeling, and MEG have found that the N1 is generated primarily from the bilateral supratemporal cortex, but also from parietal and frontal cortices (Brazdil et al 2005;Reale et al 2007;Smith et al 1990).…”

Section: Low-level Auditory Processingmentioning

confidence: 99%

“…Recently, Lepistö et al (2005Lepistö et al ( , 2006 performed two parallel studies with high functioning children with autism and with Asperger's syndrome compared to age matched controls. Speech and non-speech stimuli were presented with changes made in pitch, duration, and vowel changes.…”

Section: Auditory Social Cognition: Erps In Language Processingmentioning

confidence: 99%

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Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review

Jeste

Nelson

2008

J Autism Dev Disord

156

157

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In this paper we critically review the literature on the use of event related potentials (ERPs) to elucidate the neural sources of the core deficits in autism. We review auditory and visual ERP studies, and then review the use of ERPs in the investigation of executive function. We conclude that, in autism, impairments likely exist in both low and higher level auditory and visual processing, with prominent impairments in the processing of social stimuli. We also discuss the putative neural circuitry underlying these deficits. As we look to the future, we posit that tremendous insight can be gained by applying ERPs to the definition of endophenotypes, which, in turn, can facilitate early diagnosis and the creation of informed interventions for children with autism. KeywordsEvent related potential (ERP); Autism; Auditory processing; Visual processing Since autism was first described by Kanner over fifty years ago (Kanner 1943), the neurobiology of this disorder has become the focus of intense scientific investigation. While extensive efforts have been made in describing the behaviors that define autism, only in recent years has progress been made to elucidate the underlying neural circuitry involved in autism, through structural and, more recently, functional neuroimaging. Through these studies has come a heightened interest in aberrant neural circuitry in autism. Of the neuroimaging tools that have been used to elucidate brain circuitry, functional electrophysiology stands alone in capacity to define early (i.e. in infancy) neural markers and endophenotypes. This technique, therefore, warrants further scrutiny. Using functional electrophysiology, defined by evoked potentials and then by event related potentials (ERPs), researchers have begun to elucidate sources of the core deficits in autism

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Section: Auditory Social Cognition: Erps In Language Processingmentioning

confidence: 93%

Section: Low-level Auditory Processingmentioning

confidence: 99%

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Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review

Jeste

Nelson

2008

J Autism Dev Disord

156

157

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“…While there is ERP data on the P3a in children with autism (Lepistö et al, 2005) and indeed magnetic recordings of analogous components in healthy subjects (Huotilainen et al 2003, Alho et al 1998), this remains a promising yet not fully explored line of investigation for MEG in autism.…”

Section: Mismatch Field and Change Detectionmentioning

confidence: 99%

Electrophysiological signatures: Magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders

Roberts

Schmidt

Egeth

et al. 2008

International Journal of Psychophysiology

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While magnetoencephalography (MEG) is of increasing utility in the assessment of pediatric patients with seizure disorders, this indication reflects only a part of the clinical potential of the technology. Beyond epilepsy, a broad range of developmental psychiatric disorders require the combined offerings of spatial and temporal resolution, along with direct sensitivity to neural electrical activity, that are offered by MEG. This article reviews the application of MEG in the study of auditory processing as an aspect of language impairment in children. Potential application is elaborated in the clinical case of autism spectrum disorders, a devastating disorder with prevalence of 1 in 150, poorly served by alternative imaging modalities. MEG offers both spatial and temporal insights, tentatively described as "electrophysiological signatures". Results demonstrate the sensitivity of MEG for detection of abnormalities of auditory processing in ASD and their clinical correlates. These findings offer promise for the comprehensive assessment of developmental neuropsychiatric disorders such as autism, but also suggest avenues for the development of MEG technology to adequately meet the needs of such populations, as well as providing conduits to basic sciences including neurobiology and genetics.

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“…Relevant is also the increased prevalence of absolute pitch and musical savants in the ASD population (e.g., DePape et al 2012;Heaton et al 2008a, b, c;Miller 1989;Mottron et al 2013) and the increased prevalence of autistic traits among possessors of absolute pitch (e.g., Dohn et al 2012). The occurrence of this superior pitch processing contrasts with the inferior temporal processing abilities in ASD (such as impaired gap-in-noise detection, duration discrimination, temporalenvelope processing, temporal order judgement; e.g., Alcántara et al 2012;Bhatara et al 2013;Kwakye et al 2011;Lepisto et al 2005Lepisto et al , 2006Samson et al 2011; but see Jones et al 2009;Kasai et al 2005) and the evidence of speech perception impairments (Alcántara et al 2004;Bhatara et al 2013;Groen et al 2009) and generally delayed speech and language development (e.g., Anderson et al 2007). Speech perception has been shown to be particularly impaired while presented in noise with temporal dips (Alcántara et al 2004;Groen et al 2009) or in a competing talker condition (Alcántara et al 2004;Bhatara et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Fragile Spectral and Temporal Auditory Processing in Adolescents with Autism Spectrum Disorder and Early Language Delay

Boets

Verhoeven

Wouters

et al. 2014

J Autism Dev Disord

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We investigated low-level auditory spectral and temporal processing in adolescents with autism spectrum disorder (ASD) and early language delay compared to matched typically developing controls. Auditory measures were designed to target right versus left auditory cortex processing (i.e. frequency discrimination and slow amplitude modulation (AM) detection versus gap-in-noise detection and faster AM detection), and to pinpoint the task and stimulus characteristics underlying putative superior spectral processing in ASD. We observed impaired frequency discrimination in the ASD group and suggestive evidence of poorer temporal resolution as indexed by gapin-noise detection thresholds. These findings question the evidence of enhanced spectral sensitivity in ASD and do not support the hypothesis of superior right and inferior left hemispheric auditory processing in ASD.

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The discrimination of and orienting to speech and non-speech sounds in children with autism

Cited by 244 publications

References 58 publications

Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review

Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review

Electrophysiological signatures: Magnetoencephalographic studies of the neural correlates of language impairment in autism spectrum disorders

Fragile Spectral and Temporal Auditory Processing in Adolescents with Autism Spectrum Disorder and Early Language Delay

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