The discovery of urea stibamine

Marsden, Philip D.

doi:10.1590/s0037-86821986000200014

Cited by 4 publications

(1 citation statement)

References 2 publications

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“…These include curcumin from turmeric, Bacosides from Brahmi ( Bacopa monnieri ), and Forskolin from Coleus forskohlii . The first modern synthetic drug to be developed in India was Urea Stibamine in 1922 by UN Brahmachari against visceral leishmaniasis . Visceral leishmaniasis was a severe health burden during the early part of the 20th century, and it was a life saving drug for a large section of the population.…”

Section: Drug Discovery In Indian Pharma Industrymentioning

confidence: 99%

Drug Discovery Research in India: Current State and Future Prospects

Balganesh

Kundu

Chakraborty

et al. 2014

ACS Med. Chem. Lett.

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Indian civilization developed a strong system of traditional medicine and was one of the first nations to develop a synthetic drug. In the postindependence era, Indian pharmaceutical industry developed a strong base for production of generic drugs. Challenges for the future are to give its traditional medicine a strong scientific base and develop research and clinical capability to consistently produce new drugs based on advances in modern biological sciences.

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Section: Drug Discovery In Indian Pharma Industrymentioning

confidence: 99%

Drug Discovery Research in India: Current State and Future Prospects

Balganesh

Kundu

Chakraborty

et al. 2014

ACS Med. Chem. Lett.

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Organometallic Compounds in Chemotherapy Against Leishmania

Prado¹,

Islam²,

Frézard³

et al. 2017

Drug Discovery for Leishmaniasis

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Leishmaniasis today constitutes a major health problem and a mammoth task in the field of drug discovery. This is due to the limited arsenal of effective anti-leishmanial chemotherapeutics, painful parenteral administration, exorbitant price and numerous adverse side effects associated with current clinically established leishmanicidal drugs. These include meglumine antimoniate (Glucantime®), stibogluconate (Pentostam®), liposomal amphotericin B (AmBisome®) and miltefosine. Also, due to the frequent manifestation of chemo-resistance in some countries, an exigent and relentless requisite is to develop innovative, innocuous and valuable anti-leishmanials. Metal compounds still offer excellent prospects for finding new ‘leads’ against parasitic diseases, including leishmaniasis. A number of organometallic compounds have already been evaluated in the therapeutic area to treat and eradicate leishmaniasis. In the last two decades, several new antimony-, bismuth-, tin-, tellurium-, palladium-, rhodium-, iridium-, ruthenium- and iron-based organometallic compound have been evaluated for their anti-leishmanial activity, showing great promise for the discovery of new anti-leishmanial drugs. This chapter outlines the old and new trends, and future perspectives for this exciting research field.

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Características físico-químicas do antimoniato de meglumina em diferentes condições de armazenamento

Romero¹,

Oliveira²,

Correia³

et al. 1996

Rev. Soc. Bras. Med. Trop.

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During the period October 1992 to July 1995 we measured the osmolarity and pH of ampoules of meglumine antimoniate (glucantime) from lot 9206L-004 (manufactured by Rhodia Farma Ltd, of São Paulo, SP, Brazil) maintained in three temperature conditions namely 4 degrees C, 37 degrees C and ambiental. Although we observed statistically significant differences in osmolarity between samples, the limited number of measurements and the variation of this property in ampoules maintained at the same temperature were obstacles to obtain definitive conclusions. Such a variation was not found with pH. Assuming these parameters could reflect structural changes in the pentavalent antimony molecule, clearly further better controlled experiments are indicated.

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The discovery of urea stibamine

Cited by 4 publications

References 2 publications

Drug Discovery Research in India: Current State and Future Prospects

Drug Discovery Research in India: Current State and Future Prospects

Organometallic Compounds in Chemotherapy Against Leishmania

Características físico-químicas do antimoniato de meglumina em diferentes condições de armazenamento

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