The discovery of thienopyridine analogues as potent IκB kinase β inhibitors. Part II

Utility of thieno[2,3-b] pyridine derivatives in the synthesis of some condensed heterocyclic compounds with expected biological activity

“…The thieno [2,3-b]pyridine derivatives occupy special place and have attracted considerable attention because of their broad pharmacological activities, including anticancer [1][2][3][4][5][6][7][8][9], antiviral [10][11][12][13], anti-inflammatory [14][15][16][17], antimicrobial [18,19], antidiabetic [20][21][22][23], antihypertensive [24][25][26] and osteogenic [27,28] activities, in addition to treatment of CNS disorders [29][30][31].…”

Synthesis of some new Thieno[2,3-b]pyridines, Pyrimidino[4',5':4,5]thieno[2,3-b]pyridine and Pyridines Incorporating 5-Bromobenzofuran-2-yl Moiety

“…The IR spectrum of 6a showed no band of the CN function but the bands at 3274, 3174 (NH2 group). 1 H-NMR spectrum of 6a revealed an absence of signals of the -SCH2-group and the presence of the NH2 protons. These findings proved that the CN and the -SCH2-groups were both involved in the cyclization step leading to 6a.…”

“…Compound 5b was converted to (3-amino-6-(5-bromobenzofuran-2-yl)thieno [2,3-b]pyridin-2-yl)(phenyl)methanone (6b) by its boiling in ethanolic piperidine solution. 1 H-NMR of 6b showed signals at δ 4.05 (s, 2H, NH2), and 7.14-7.78 (m, 11H, ArH's) (Scheme 1).…”

“…The thieno [2,3-b]pyridine derivatives occupy special place and have attracted considerable attention because of their broad pharmacological activities, including anticancer [1][2][3][4][5][6][7][8][9], antiviral [10][11][12][13], anti-inflammatory [14][15][16][17], antimicrobial [18,19], antidiabetic [20][21][22][23], antihypertensive [24][25][26] and osteogenic [27,28] activities, in addition to treatment of CNS disorders [29][30][31]. Also, pyridine derivatives of different heterocyclic nucleus have shown potent pharmacological properties like antifungal [32,33], antitubercular [34], antibacterial [35], antimicrobial [36], insecticida [37].…”

Synthesis of 4-Benzo[1,3]Dioxol-5-Ylthieno-[2,3-b]Pyridines

“…Some of them possess cytotoxic [1][2][3][4], antiinflammatory [5,6], antiviral [7], antibacterial [8,9] activity. Others are useful as hypolipoproteinemic and antiatherosclerotic agents [10] and inhibitors of mitogen-activated protein kinase enzymes, and are accordingly of benefit as pharmaceutical agents, especially in the treatment of adverse inflammatory, autoimmune, cardiovascular, proliferative and nociceptive conditions [11].…”