The discovery of indazapyroxamet: a novel 3‐pyridinyl insecticide targeting piercing/sucking insects^a

Abstract

In recent years, the registrations for a number of commercial insecticides utilized for piercing/sucking insects have been cancelled or restricted. To meet this growing need for new hemipteran controlling agrochemicals, we discovered a 2‐(pyridin‐3‐yl)‐thiazole compound, with limited insecticidal activity against cotton/melon aphid (Aphis gossypii). The 2‐(pyridin‐3‐yl)‐thiazole moiety offered us a basis to pursue the bicyclic 2‐(pyridin‐3‐yl)‐2H‐indazole carboxamides. Evaluation of such 2‐(pyridin‐3‐yl)‐2H‐indazole carboxamides revealed that even analogs containing only simple alkyl amides attached at the 4 or 5 positions possess promising insecticidal activity. Extensive optimization of this novel class of 2‐(pyridin‐3‐yl)‐2H‐indazole carboxamides led to identifying indazapyroxamet for commercial development. © 2024 Society of Chemical Industry.