The discovery of IgE

Stanworth, D.R.

doi:10.1111/j.1398-9995.1993.tb00687.x

Cited by 42 publications

(26 citation statements)

References 22 publications

(15 reference statements)

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“…However, despite extensive research, the short half-life and low abundance of IgE masked its molecular identity until it was finally isolated in the late 1960s (Stanworth, 1993).…”

Section: Introductionmentioning

confidence: 99%

Fluorescent In Vivo Detection Reveals that IgE+ B Cells Are Restrained by an Intrinsic Cell Fate Predisposition

2012

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IgE antibodies may be protective in parasite immunity, but their aberrant production can lead to allergic disease and life-threatening anaphylaxis. Despite the importance of IgE regulation, few studies have directly examined the B cells that express IgE, because these cells are rare and difficult to detect. Here, we describe fluorescent IgE reporter mice and validate a flow cytometry procedure to allow sensitive and specific identification of IgE-expressing B cells in vivo. Similar to IgG1(+) cells, IgE(+) B cells differentiated into germinal center (GC) B cells and plasma cells (PCs) during primary immune responses to a T cell-dependent hapten-protein conjugate and the helminth Nippostrongylus brasiliensis. However, the participation of IgE(+) B cells in GCs was transient. IgE(+) B cells had an atypical propensity to upregulate the transcription factor Blimp-1 and undergo PC differentiation. Most IgE(+) PCs were short lived and showed reduced affinity maturation, revealing intrinsic mechanisms that restrict the IgE antibody response.

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“…However, despite extensive research, the short half-life and low abundance of IgE masked its molecular identity until it was finally isolated in the late 1960s (Stanworth, 1993).…”

Section: Introductionmentioning

confidence: 99%

Fluorescent In Vivo Detection Reveals that IgE+ B Cells Are Restrained by an Intrinsic Cell Fate Predisposition

2012

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“…However, it is important to remember that myeloma proteins do not have known antigen specificity which made it difficult to investigate the biological activity. Nonetheless, in 1967 working with Dennis Stanworth and John Humphrey in the UK they digested the molecule with Papain and reported that the Fc fragment of the ND protein could inhibit PK activity 15–17 . One of the most remarkable things about the whole story is that the Radio-Allergo Sorbent test (RAST) for IgE antibodies was also published in 1967 18 .…”

Section: Demonstration That a Myeloma Derived Protein Nd Was Not Igmmentioning

confidence: 99%

The discovery of IgE 50 years later

Platts-Mills

Heymann

Commins

et al. 2016

Annals of Allergy, Asthma & Immunology

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“…Fifty years after demonstration that IgE is capable of transferring sensitivity to allergens (for history of IgE see Stanworth, 1993), we understand that IgE acts as part of protein network which includes FcεRI, CD23 and galectin-3. Additional co-receptor involved in IgE actionis CR3.…”

Section: Basic Information About Allergiesmentioning

confidence: 99%

β-Glucan in Allergies

Šíma¹,

Větvička²

2017

American Journal of Immunology

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Multiple effects of β-glucan are well established. Together with the effects on antibacterial and anticancer immunity, glucan has been shown to stimulate bone marrow cells, lower cholesterol and to protects against stress and some kinds of poisoning. However, despite literally thousands of papers describing biological effects of β-glucan, only limited attention has been focused on the role of β-glucan in allergic reactions. Our review is focused on evaluating the current knowledge of the possible role of β-glucan in allergic reactions. Most of published studies concur that based on the improved Th1/Th2 balance, β-glucan showed a potential for development as an adjunct to the standard treatment of in patients with allergies.

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The discovery of IgE

Cited by 42 publications

References 22 publications

Fluorescent In Vivo Detection Reveals that IgE+ B Cells Are Restrained by an Intrinsic Cell Fate Predisposition

Fluorescent In Vivo Detection Reveals that IgE+ B Cells Are Restrained by an Intrinsic Cell Fate Predisposition

The discovery of IgE 50 years later

β-Glucan in Allergies

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The discovery of IgE

Cited by 42 publications

References 22 publications

Fluorescent In Vivo Detection Reveals that IgE+ B Cells Are Restrained by an Intrinsic Cell Fate Predisposition

Fluorescent In Vivo Detection Reveals that IgE+ B Cells Are Restrained by an Intrinsic Cell Fate Predisposition

The discovery of IgE 50 years later

&beta;-Glucan in Allergies

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β-Glucan in Allergies