The discovery of autoantibody to deoxyribonucleic acid

Holman, Halsted R.

doi:10.1177/0961203310392433

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2014

2021

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Cited by 3 publications

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“…Historically, the first clinically relevant autoantibodies were discovered in the mid-20th century following observations of the morphological effects of serum on leukocytes ( 5 , 6 ). Over the remainder of the 20th century, new techniques emerged which allowed for greater ease of use and specificity.…”

Section: Introductionmentioning

confidence: 99%

Protein Microarrays: A New Tool for the Study of Autoantibodies in Immunodeficiency

Rosenberg

Utz

2015

Front. Immunol.

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Autoimmunity is highly coincident with immunodeficiency. In a small but growing number of primary immunodeficiencies, autoantibodies are diagnostic of a given disease and implicated in disease pathogenesis. In order to improve our understanding of the role of autoantibodies in immunodeficiencies and to discover novel autoantibodies, new proteomic tools are needed. Protein microarrays have the ability to screen for reactivity to hundreds to many thousands of unique autoantigens simultaneously on a single chip using minimal serum input. Here, we review different types of protein microarrays and how they can be useful in framing the study of primary and secondary immunodeficiencies.

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Section: Introductionmentioning

confidence: 99%