The Discovery and Development of Cisplatin

Alderden, Rebecca A.; Hall, Matthew D.; Hambley, Trevor W.

doi:10.1021/ed083p728

Cited by 440 publications

(375 citation statements)

References 49 publications

Supporting

Mentioning

353

Contrasting

Unclassified

Order By: Relevance

“…17 in 1960s The anticancer action of cisplatin was exposed serendipitously. 18 Meanwhile in 1978 it has been used in clinics in contradiction of a diversity of cancers including ovarian, testicular, bladder, head and neck, lymphoma, cervical and melanoma. Treatment with cisplatin regularly reasons severe side effects for example vomiting, nausea, neurotoxicity, nephrotoxicity, emetogenesis and myelotoxicity.…”

Section: Introductionmentioning

confidence: 99%

“…17 These side effects rise mostly as a result of the limited selectivity of cisplatin for tumor cells as compared to healthy cells 19 and may similarly be due to reactions with Thiol containing types in blood plasma, such as cysteine and human serum albumin. 18 The cellular mechanisms of cisplatin resistance have been identified. 20 The highest factors that modulate resistance include, declined drug accumulation and increased levels of intracellular Thiols that can deactivate cisplatin and capability of cells to repair or tolerate DNA damage caused by cisplatin.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and In vitro Cytotoxicity of a Novel Efficient Cisplatin-loaded poly N-butyl cyanoacrylate.

Haghnazari¹,

Mohammadi²,

Mokhtari³

et al. 2016

IJPER

View full text Add to dashboard Cite

Purpose: Typically, drug-loaded polymer colloidal carriers are synthesized by the drug entrapment during anionic emulsion polymerization. The purpose of this study was to trial the ability of Cisplatin-loaded Poly Butyl Cyanoacrylate (PBCA) nanoparticles. Methods: The cytotoxicity of Cisplatin-loaded PBCA nanoparticles was evaluated by MT assay. The Polymeric nanoparticles have been characterized using TEM, SEM, FTIR and DLS. Results: Polymeric nanoparticles with loaded and unloaded drug prepared by this method, have spherical structure with 350 and 230 nm in diameter and their zeta potentials were -3.2 and -10.7 mv respectively. The average amount of drug loaded on the nanoparticles was 70.88 ± 5.51%. MTT assay was carried out to evaluate the cytotoxicity property of the nanoparticles. Inhibition concentration values (IC 50 ) for Cisplatin-loaded Nanoparticles were 20.8 and 18.2 μM for 24 and 48 h respectively. Conclusion: It was shown that cisplatin-loaded nanoparticles strongly increased cytotoxicity in comparison to classic drug in the MCF-7 cell line.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and In vitro Cytotoxicity of a Novel Efficient Cisplatin-loaded poly N-butyl cyanoacrylate.

Haghnazari¹,

Mohammadi²,

Mokhtari³

et al. 2016

IJPER

View full text Add to dashboard Cite

show abstract

“…While DNA is a well-established biomolecular target for anti-cancer therapy, most DNAbinding drugs such as cisplatin (Alderden et al 2006) and its analogues interact with DNA non-selectively, resulting in adverse side effects (Jung et al 2007). Consequently, this has driven interest in the targeting of unusual, non-canonical structures in DNA, in order to achieve selectivity for particular (onco)genes while potentially reducing adverse side effects.…”

Section: Introductionmentioning

confidence: 99%

Structure-Based Approaches Targeting Oncogene Promoter G-Quadruplexes

Ma¹,

Yan²,

Leung³

et al. 2013

Oncogene and Cancer - From Bench to Clinic

View full text Add to dashboard Cite

“…Cisplatin (cis-diaminedichloroplatinum(II)) was the first truly effective anticancer drug; its discovery and development has been recently reviewed [10]. The ability to crosslink DNA is thought to be the main mode by which cisplatin stops cell division and thus cancer growth.…”

Section: Introductionmentioning

confidence: 99%

Alternative organic solvents for HILIC separation of cisplatin species with on‐line ICP‐MS detection

Hemström

Nygren

Björn

et al. 2008

J of Separation Science

View full text Add to dashboard Cite

Several low volatile organic solvents were evaluated as organic modifiers in eluents for HILIC separations of cisplatin species to optimize the on-line coupling of HILIC to inductively coupled plasma MS (ICP-MS). The aim was to identify a solvent giving low solvent vapor loading of the ICP, to maximize analyte sensitivity and minimize carbon depositions on instrumental parts, while retaining chromatographic performance. The best overall performance of the HILIC-ICP-MS system for the analysis of cisplatin was achieved using 1,4-dioxane as eluent, yielding high retention and an HILIC type retention mechanism, at the expense of a 50% drop in column efficiency due to the higher viscosity of 1,4-dioxane compared to the more commonly used HILIC solvent ACN. Using 1,4-dioxane as solvent in HILIC provides the best compromise between carbon deposition and separation efficiency among a series of high-boiling water-miscible solvents tested.

show abstract

The Discovery and Development of Cisplatin

Cited by 440 publications

References 49 publications

Synthesis and In vitro Cytotoxicity of a Novel Efficient Cisplatin-loaded poly N-butyl cyanoacrylate.

Synthesis and In vitro Cytotoxicity of a Novel Efficient Cisplatin-loaded poly N-butyl cyanoacrylate.

Structure-Based Approaches Targeting Oncogene Promoter G-Quadruplexes

Alternative organic solvents for HILIC separation of cisplatin species with on‐line ICP‐MS detection

Contact Info

Product

Resources

About