The Discoidin domain receptor 1 gene has a functional A2RE sequence

Roig, Bárbara; Moyano, Sílvia; Martorell, Lourdes; Costas, Javier; Vilella, Elisabet

doi:10.1111/j.1471-4159.2011.07580.x

Cited by 23 publications

(10 citation statements)

References 42 publications

(97 reference statements)

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“…Likewise, the DNA repair protein XRCC3, which is induced by genotoxic stress, can up-regulate DDR1 expression (Martinez-Marignac et al, 2011). The DDR1 gene also contains a hnRNP A2 response element sequence, which may be involved in alternative splicing and nuclear export of DDR1 mRNA in oligodendrocytes (Roig et al, 2012). DDR1 expression is downregulated during induction of epithelial-mesenchymal transition (EMT).…”

Section: Ddr Structure and Ligand Interactionsmentioning

confidence: 99%

Discoidin Domain Receptor Functions in Physiological and Pathological Conditions

Leitinger

2014

International Review of Cell and Molecular Biology

308

362

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The discoidin domain receptors, DDR1 and DDR2, are non-integrin collagen receptors that are members of the receptor tyrosine kinase family. Both DDRs bind a number of different collagen types and play important roles in embryo development. Dysregulated DDR function is associated with progression of various human diseases, including fibrosis, arthritis and cancer. By interacting with key components of the extracellular matrix and displaying distinct activation kinetics, the DDRs form a unique subfamily of receptor tyrosine kinases. DDR-facilitated cellular functions include cell migration, cell survival, proliferation and differentiation, as well as remodelling of extracellular matrices. This review summarises the current knowledge of DDR-ligand interactions, DDR-initiated signal pathways and the molecular mechanisms that regulate receptor function. Also discussed are the roles of DDRs in development and disease progression.

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Section: Ddr Structure and Ligand Interactionsmentioning

confidence: 99%

Discoidin Domain Receptor Functions in Physiological and Pathological Conditions

Leitinger

2014

International Review of Cell and Molecular Biology

308

362

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“…A2‐mediated RNA transport is specific to an A2RE or A2RE‐like motif, which can be found in a large number of RNAs, such as the mRNA of MBP (Makeyev & Liebhaber, 2002), CaMKII (Ca2+/calmodulin‐dependent protein kinase II, Arc (activity‐regulated cytoskeleton‐associated protein), neurogranin (Gao, Tatavarty, Korza, Levin, & Carson, 2008), MAP2A, GABA receptor α (Munro et al, 1999), and Discoidin domain receptor 1 (Roig, Moyano, Martorell, Costas, & Vilella, 2012). However, the A2 protein also mediates noncanonical motif transport pathways.…”

Section: Hnrnpa2/b1 In Rna Biologymentioning

confidence: 99%

The roles of hnRNP A2/B1 in RNA biology and disease

Liu

Shi

2020

WIREs RNA

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The RNA‐binding protein hnRNPA2/B1 is a member of the hnRNPs family and is widely expressed in various tissues. hnRNPA2/B1 recognizes and binds specific RNA substrates and DNA motifs and is involved in the transcription, splicing processing, transport, stability, and translation regulation of a variety of RNA molecules and in regulating the expression of a large number of genes. hnRNPA2/B1 is also involved in telomere maintenance and DNA repair, while its expression changes and mutations are involved in the development of various tumors and neurodegenerative and autoimmune diseases. This paper reviews the role and mechanism of hnRNPA2/B1 in RNA metabolism, tumors, and neurodegenerative and autoimmune diseases. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein‐RNA Interactions: Functional Implications RNA in Disease and Development > RNA in Disease

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“…Similarly, overexpression of the DNA repair protein XRCC3, results in DDR1 upregulation by an as yet unknown mechanism [73]. A recent study in oligodendrocytes found that the DDR1 gene contains an hnRNP A2 response element-like sequence, which may be involved in alternative splicing and nuclear export of DDR1 mRNA [74]. Also, DDR1 mRNA is a direct target of the microRNA miR-199a-5p; levels of miR-199a-5p inversely correlate with DDR1 expression in human hepatocellular carcinoma cells [75].…”

Section: Regulation Of Ddr Expressionmentioning

confidence: 99%

Discoidin domain receptor tyrosine kinases: new players in cancer progression

Valiathan

Marco

Leitinger

et al. 2012

Cancer Metastasis Rev

327

389

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Almost all human cancers display dysregulated expression and/or function of one or more receptor tyrosine kinases (RTKs). The strong causative association between altered RTK function and cancer progression has translated into novel therapeutic strategies that target these cell surface receptors in the treatment of cancer. Yet, the full spectrum of RTKs that may alter the oncogenic process is not completely understood. Accumulating evidence suggests that a unique set of RTKs known as the Discoidin Domain Receptors (DDRs) play a role in cancer progression by regulating the interactions of tumor cells with their surrounding collagen matrix. The DDRs are the only RTKs that specifically bind to, and are activated by collagen. Hence, the DDRs are part of the signaling networks that translate information from the extracellular matrix thereby acting as key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting as collagen sensors, transducing signals that regulate cell polarity, tissue morphogenesis, and cell differentiation. In cancer, DDRs are hijacked by tumor cells to disrupt normal cell-matrix communication and initiate pro-migratory and pro-invasive programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function and contribute to cancer progression. Other evidence suggests that the actions of DDRs in cancer are complex, either promoting or suppressing tumor cell behavior in a DDR type/isoform specific and context dependent manner. Thus, there is still a considerable gap in our knowledge of DDR actions in cancer tissues. This review summarizes the current knowledge on DDR expression and function in cancer and discusses the potential implications of DDRs in cancer biology. It is hoped that this effort will encourage more research into these poorly understood but unique RTKs, which have the potential of becoming novel therapeutics targets in cancer.

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The Discoidin domain receptor 1 gene has a functional A2RE sequence

Cited by 23 publications

References 42 publications

Discoidin Domain Receptor Functions in Physiological and Pathological Conditions

Discoidin Domain Receptor Functions in Physiological and Pathological Conditions

The roles of hnRNP A2/B1 in RNA biology and disease

Discoidin domain receptor tyrosine kinases: new players in cancer progression

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